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ONTOLOGY REPORT - ANNOTATIONS

Term:Weibel-Palade body
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Accession:GO:0033093 term browser browse the term
Definition:A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.
Synonyms:xref: Wikipedia:Weibel-Palade_body


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Weibel-Palade body term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apold1 apolipoprotein L domain containing 1 located_in ISS
ISO		 GO_REF:0000024
(PMID:35638551)		 UniProt
RGD		 PMID:35638551 GO_REF:0000024 NCBI chr 4:169,499,728...169,557,075
Ensembl chr 4:167,818,271...167,825,706 		JBrowse link
G Cracr2a calcium release activated channel regulator 2A located_in ISO (PMID:31092558) RGD PMID:31092558 NCBI chr 4:162,094,247...162,207,926
Ensembl chr 4:160,408,077...160,518,107 		JBrowse link
G Ece1 endothelin converting enzyme 1 located_in ISO
IEA		 (PMID:9710124)
GO_REF:0000107		 RGD
Ensembl		 PMID:9710124 GO_REF:0000107 NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 IDA RGD PMID:10903535 RGD:8662311 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family located_in IDA PMID:22899725 UniProt PMID:22899725 RGD:10047177 NCBI chr 8:82,663,373...82,717,267
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Unc13d unc-13 homolog D located_in ISO (PMID:22899725) RGD PMID:22899725 NCBI chr10:101,795,652...101,810,409
Ensembl chr10:101,296,776...101,311,687 		JBrowse link
G Vwf von Willebrand factor located_in ISO
IEA		 (PMID:3082891), (PMID:3087627)
GO_REF:0000104
(PMID:30573509)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:3082891 PMID:3087627 PMID:30573509 GO_REF:0000104 GO_REF:0000107 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21364
    cellular anatomical structure 21069
      endomembrane system 4414
        secretory granule 479
          Weibel-Palade body 7
Path 2
Term Annotations click to browse term
  cellular_component 21364
    cellular anatomical structure 21069
      organelle 14290
        intracellular organelle 13880
          intracellular membrane-bounded organelle 12307
            intracellular vesicle 2080
              cytoplasmic vesicle 2071
                coated vesicle 241
                  clathrin-coated vesicle 147
                    Weibel-Palade body 7
paths to the root