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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell differentiation in thymus
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Accession:GO:0033077 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: thymic T cell differentiation;   thymocyte cell differentiation;   thymocyte differentiation
 related_synonym: T cell development in thymus


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T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in IEA
ISO 		GO_REF:0000107
(PMID:17371977) 		Ensembl
RGD		 PMID:17371977 GO_REF:0000107 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO MGI:3589207 (PMID:16025118) RGD PMID:16025118 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G B2m beta-2 microglobulin acts_upstream_of_or_within ISO MGI:95663 (PMID:18776904) RGD PMID:18776904 NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356 		JBrowse link
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2663971 (PMID:16670294) 		Ensembl
RGD		 PMID:16670294 GO_REF:0000107 NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:132,598,968...132,691,301 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (PMID:8170972), (PMID:9028316) RGD PMID:8170972 PMID:9028316 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex IEP RGD PMID:11896936 RGD:2313407 NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:54,200,617...54,211,876 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3833563|MGI:5141514 (PMID:21508411) 		Ensembl
RGD		 PMID:21508411 GO_REF:0000107 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1858008 (PMID:16025118) 		Ensembl
RGD		 PMID:16025118 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2448686|MGI:3040717 (PMID:15879105) 		Ensembl
RGD		 PMID:15879105 GO_REF:0000107 NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599 		JBrowse link
G Fadd Fas associated via death domain involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:21876153)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:21876153 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fzd5 frizzled class receptor 5 acts_upstream_of_or_within ISO (PMID:11265645) RGD PMID:11265645 NCBI chr 9:73,606,860...73,614,039
Ensembl chr 9:73,606,860...73,618,612 		JBrowse link
G Fzd7 frizzled class receptor 7 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:11265645) 		Ensembl
RGD		 PMID:11265645 GO_REF:0000107 NCBI chr 9:68,425,538...68,428,357
Ensembl chr 9:68,411,259...68,432,585 		JBrowse link
G Fzd8 frizzled class receptor 8 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:11265645) 		Ensembl
RGD		 PMID:11265645 GO_REF:0000107 NCBI chr17:62,007,849...62,015,485
Ensembl chr17:62,007,627...62,015,961 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2153825|MGI:2683927|MGI:4418042|MGI:88127 (PMID:14670303), (PMID:18776904), (PMID:19934022), (PMID:8945476) 		Ensembl
RGD		 PMID:8945476 PMID:14670303 PMID:18776904 PMID:19934022 GO_REF:0000107 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Gba1 glucosylceramidase beta 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:22665763) 		Ensembl
RGD		 PMID:22665763 GO_REF:0000107 NCBI chr 2:176,902,141...176,916,015
Ensembl chr 2:176,907,154...176,916,985 		JBrowse link
G Gli3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000107
MGI:1856276 (PMID:15855276) 		Ensembl
RGD		 PMID:15855276 GO_REF:0000107 NCBI chr17:54,134,064...54,405,198
Ensembl chr17:54,134,064...54,405,198 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:70,435,343...70,439,161 		JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3043930 (PMID:14715629) 		Ensembl
RGD		 PMID:14715629 GO_REF:0000107 NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,539,894...102,545,986 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (PMID:10911993), (PMID:9823897) RGD PMID:9823897 PMID:10911993 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926 		JBrowse link
G Mafb MAF bZIP transcription factor B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3663168 (PMID:19164599) 		Ensembl
RGD		 PMID:19164599 GO_REF:0000107 NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:169,416,945...169,419,975 		JBrowse link
G Mpzl2 myelin protein zero-like 2 acts_upstream_of_or_within ISO (PMID:19851463) RGD PMID:19851463 NCBI chr 8:54,244,920...54,256,064
Ensembl chr 8:54,243,556...54,256,074 		JBrowse link
G Mr1 major histocompatibility complex, class I-related involved_in IEA
ISO 		GO_REF:0000107
(PMID:12634786) 		Ensembl
RGD		 PMID:12634786 GO_REF:0000107 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502 		JBrowse link
G Ncaph2 non-SMC condensin II complex, subunit H2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3710093 (PMID:17640884) 		Ensembl
RGD		 PMID:17640884 GO_REF:0000107 NCBI chr 7:122,302,550...122,319,570
Ensembl chr 7:122,300,252...122,319,569 		JBrowse link
G Nkap NFKB activating protein acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3765313|MGI:4839023 (PMID:20610818) 		Ensembl
RGD		 PMID:20610818 GO_REF:0000107 NCBI chr  X:121,238,714...121,258,360
Ensembl chr  X:121,238,404...121,261,238 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2383951 (PMID:9768755) 		Ensembl
RGD		 PMID:9768755 GO_REF:0000107 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108 		JBrowse link
G Psmb11 proteasome subunit beta 11 acts_upstream_of_or_within ISO (PMID:31915251) RGD PMID:31915251 NCBI chr15:32,054,747...32,055,666
Ensembl chr15:32,049,118...32,056,299 		JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:32220963) 		Ensembl
RGD		 PMID:32220963 GO_REF:0000107 NCBI chr11:76,658,723...76,687,681
Ensembl chr11:76,658,723...76,687,940 		JBrowse link
G Rag1 recombination activating 1 involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000104
(PMID:1547488)
MGI:2448994 (PMID:9215624)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:1547488 PMID:9215624 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:108,371,978...108,383,261 		JBrowse link
G Rag2 recombination activating 2 involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000107
MGI:1858556 (PMID:9875844)
(PMID:1547488) 		Ensembl
RGD		 PMID:1547488 PMID:9875844 GO_REF:0000107 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:108,357,399...108,365,253 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO 		GO_REF:0000024
UniProtKB:Q61160 (PMID:21876153) 		UniProt
RGD		 PMID:21876153 GO_REF:0000024 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025 		JBrowse link
G Rorc RAR-related orphan receptor C acts_upstream_of_or_within ISO MGI:3026635 (PMID:15247480) RGD PMID:15247480 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within ISO MGI:2387471|MGI:98834 (PMID:16357222) RGD PMID:16357222 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of 		ISS
ISO
IEA 		GO_REF:0000024
(PMID:19273836)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:19273836 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:103035 (PMID:15294943) 		Ensembl
RGD		 PMID:15294943 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:103036 (PMID:15294943) 		Ensembl
RGD		 PMID:15294943 GO_REF:0000107 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within ISO MGI:2178112 (PMID:18958875) RGD PMID:18958875 NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,928,685...9,953,044 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Wnt1 Wnt family member 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:11265645) 		Ensembl
RGD		 PMID:11265645 GO_REF:0000107 NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:131,817,558...131,821,605 		JBrowse link
G Wnt4 Wnt family member 4 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:11265645) 		Ensembl
RGD		 PMID:11265645 GO_REF:0000107 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771 (PMID:9875844) RGD PMID:9875844 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160 		JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5300200 (PMID:22201126) 		Ensembl
RGD		 PMID:22201126 GO_REF:0000107 NCBI chr 6:100,832,506...100,864,019
Ensembl chr 6:100,838,714...100,852,643 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 involved_in ISS
ISO 		GO_REF:0000024
UniProtKB:P23949 (PMID:20622884) 		UniProt
RGD		 PMID:20622884 GO_REF:0000024 NCBI chr 6:104,663,396...104,669,815
Ensembl chr 6:104,663,399...104,687,979 		JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P23950 (PMID:20622884) 		Ensembl
RGD		 PMID:20622884 GO_REF:0000107 NCBI chr 6:16,242,622...16,246,662
Ensembl chr 6:16,242,610...16,246,653 		JBrowse link
DN2 thymocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24638065) 		Ensembl
RGD		 PMID:24638065 GO_REF:0000107 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059 		JBrowse link
G Rag2 recombination activating 2 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:108,357,399...108,365,253 		JBrowse link
DN3 thymocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24638065) 		Ensembl
RGD		 PMID:24638065 GO_REF:0000107 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059 		JBrowse link
DN4 thymocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within
involved_in 		IEA GO_REF:0000107
GO_REF:0000117 		Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr13:71,223,902...71,319,770
Ensembl chr13:71,224,019...71,389,775 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:17579027) 		UniProt
RGD		 PMID:17579027 GO_REF:0000024 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992 		JBrowse link
immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4g C-type lectin domain family 4, member G acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr12:6,578,266...6,582,913
Ensembl chr12:6,578,258...6,582,894 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663 		JBrowse link
G Wnt4 Wnt family member 4 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1857453 (PMID:18617424) 		Ensembl
RGD		 PMID:18617424 GO_REF:0000107 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128 		JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:12421925) 		Ensembl
UniProt
RGD		 PMID:12421925 GO_REF:0000024 GO_REF:0000107 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:15964995) RGD PMID:15964995 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr12:6,578,266...6,582,913
Ensembl chr12:6,578,258...6,582,894 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:16230479) 		Ensembl
RGD		 PMID:16230479 GO_REF:0000107 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA
ISO 		GO_REF:0000107
(PMID:19109233) 		Ensembl
RGD		 PMID:19109233 GO_REF:0000107 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203 		JBrowse link
G Tmem131l transmembrane 131 like involved_in ISO
IEA 		(PMID:23690469)
GO_REF:0000107 		RGD
Ensembl		 PMID:23690469 GO_REF:0000107 NCBI chr 2:171,555,673...171,689,774
Ensembl chr 2:171,555,673...171,689,733 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:22080863) 		UniProt
Ensembl
RGD		 PMID:22080863 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481 		JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO
IEA 		(PMID:12421925)
GO_REF:0000107 		RGD
Ensembl		 PMID:12421925 GO_REF:0000107 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172 		JBrowse link
G Foxj1 forkhead box J1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:16339515) 		Ensembl
RGD		 PMID:16339515 GO_REF:0000107 NCBI chr10:102,065,163...102,069,945
Ensembl chr10:102,065,170...102,069,241 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA
ISO 		GO_REF:0000107
(PMID:19109233) 		Ensembl
RGD		 PMID:19109233 GO_REF:0000107 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203 		JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (PMID:11931770) RGD PMID:11931770 NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:94,808,453...94,817,861 		JBrowse link
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:108,357,399...108,365,253 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Zc3h8 zinc finger CCCH type containing 8 involved_in ISO
IEA 		(PMID:12153508)
GO_REF:0000107 		RGD
Ensembl		 PMID:12153508 GO_REF:0000107 NCBI chr 3:136,629,998...136,646,998
Ensembl chr 3:136,629,999...136,646,952 		JBrowse link
negative thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
MGI:1277186 (PMID:23382543)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:23382543 GO_REF:0000033 GO_REF:0000107 NCBI chr20:10,635,775...10,650,709
Ensembl chr20:10,635,775...10,650,709 		JBrowse link
G Atg5 autophagy related 5 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1338803|MGI:3612279 (PMID:23382543) 		Ensembl
RGD		 PMID:23382543 GO_REF:0000107 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:17785582) 		Ensembl
RGD		 PMID:17785582 GO_REF:0000107 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (PMID:10429671) RGD PMID:10429671 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (PMID:7630421) RGD PMID:7630421 NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:54,200,617...54,211,876 		JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205 (PMID:7679955) RGD PMID:7679955 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2152031 (PMID:12871644) 		Ensembl
RGD		 PMID:12871644 GO_REF:0000107 NCBI chr10:19,331,412...19,748,987
Ensembl chr10:19,331,412...19,748,969 		JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (PMID:10429671) RGD PMID:10429671 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Gli3 GLI family zinc finger 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19667090) 		Ensembl
RGD		 PMID:19667090 GO_REF:0000107 NCBI chr17:54,134,064...54,405,198
Ensembl chr17:54,134,064...54,405,198 		JBrowse link
G Mink1 misshapen-like kinase 1 acts_upstream_of_or_within ISO (PMID:15608642) RGD PMID:15608642 NCBI chr10:55,776,879...55,829,406
Ensembl chr10:55,776,993...55,829,406 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (PMID:8666928) RGD PMID:8666928 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:17227833)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:17227833 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Spn sialophorin acts_upstream_of_or_within ISO MGI:1857246 (PMID:10429671) RGD PMID:10429671 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2677447 (PMID:7630421) 		Ensembl
RGD		 PMID:7630421 GO_REF:0000107 NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:46,485,598...46,509,062 		JBrowse link
positive regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmi1 BMI1 proto-oncogene, polycomb ring finger involved_in IEA
ISO 		GO_REF:0000107
(PMID:15964995) 		Ensembl
RGD		 PMID:15964995 GO_REF:0000107 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1857034 (PMID:16230479) 		Ensembl
RGD		 PMID:16230479 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Il1a interleukin 1 alpha involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta involved_in IDA
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:8590311 GO_REF:0000033, RGD:7401228 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:14764698), (PMID:19273836)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:14764698 PMID:19273836 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
positive regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1857117|MGI:2683027 (PMID:11067867), (PMID:11435465), (PMID:12163459), (PMID:16670300) 		Ensembl
RGD		 PMID:11067867 PMID:11435465 PMID:12163459 PMID:16670300 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 involved_in IEA
ISO 		GO_REF:0000107
(PMID:20856819) 		Ensembl
RGD		 PMID:20856819 GO_REF:0000107 NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:204,206,199...204,218,485 		JBrowse link
G Egr3 early growth response 3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:21737317) 		Ensembl
RGD		 PMID:21737317 GO_REF:0000107 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA
ISO 		GO_REF:0000107
(PMID:19109233) 		Ensembl
RGD		 PMID:19109233 GO_REF:0000107 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1857455|MGI:2429736 (PMID:9252128), (PMID:9916699) 		Ensembl
RGD		 PMID:9252128 PMID:9916699 GO_REF:0000107 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:70,435,343...70,439,161 		JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of_or_within ISO MGI:1857198 (PMID:9215626) RGD PMID:9215626 NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:11017103) 		Ensembl
RGD		 PMID:11017103 GO_REF:0000107 NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:19109233)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:19109233 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Vnn1 vanin 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:8934567) 		Ensembl
RGD		 PMID:8934567 GO_REF:0000107 NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629 		JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO MGI:2180711 (PMID:9133426) RGD PMID:9133426 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:174,721,522...174,725,029 		JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex involved_in ISS
ISO
IBA 		GO_REF:0000024
(PMID:9135151)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:9135151 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:54,175,155...54,196,722 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:54,200,617...54,211,876 		JBrowse link
G Cd3g CD3 gamma subunit of T-cell receptor complex involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:54,177,572...54,184,087
Ensembl chr 8:54,177,977...54,183,918 		JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205|MGI:1927530 (PMID:7679955), (PMID:8598040), (PMID:9432982) RGD PMID:7679955 PMID:8598040 PMID:9432982 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2152031 (PMID:12871644) 		Ensembl
RGD		 PMID:12871644 GO_REF:0000107 NCBI chr10:19,331,412...19,748,987
Ensembl chr10:19,331,412...19,748,969 		JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3039799 (PMID:15064401) 		Ensembl
RGD		 PMID:15064401 GO_REF:0000107 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:94,601,167...94,696,179 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:17579027) 		UniProt
RGD		 PMID:17579027 GO_REF:0000024 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (PMID:8666928) RGD PMID:8666928 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746 		JBrowse link
G RT1-DMa RT1 class II, locus DMa acts_upstream_of_or_within ISO MGI:1861933|MGI:2384509|MGI:2652160 (PMID:8598040), (PMID:8598041), (PMID:8638109), (PMID:9432982) RGD PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chr20:4,708,932...4,712,335
Ensembl chr20:4,708,933...4,712,335 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:17227833)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:17227833 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2449947|MGI:3046779 (PMID:21098124) 		Ensembl
RGD		 PMID:21098124 GO_REF:0000107 NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:21,924,076...21,933,337 		JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within ISO MGI:2386448|MGI:2387402|MGI:3054844 (PMID:21487392) RGD PMID:21487392 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:7630421)
MGI:2677447 (PMID:7630421)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:7630421 GO_REF:0000107 GO_REF:0000117 NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:46,485,598...46,509,062 		JBrowse link
regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule involved_in ISO (PMID:11550008) RGD PMID:11550008 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:174,721,522...174,725,029 		JBrowse link
G Tnfsf9 TNF superfamily member 9 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339 		JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24184560) 		Ensembl
RGD		 PMID:24184560 GO_REF:0000107 NCBI chr10:63,749,461...63,778,468
Ensembl chr10:63,749,461...63,771,771 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in IEA
ISO 		GO_REF:0000107
(PMID:18195075) 		Ensembl
RGD		 PMID:18195075 GO_REF:0000107 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:24,672,487...24,968,754 		JBrowse link
regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in IMP
IEA 		GO_REF:0000117 UniProt
RGD		 PMID:3876160 GO_REF:0000117, RGD:152995412 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor involved_in ISO (PMID:21048919) RGD PMID:21048919 NCBI chr 3:187,643,043...187,647,805
Ensembl chr 3:187,642,654...187,648,483 		JBrowse link
G Ankle1 ankyrin repeat and LEM domain containing 1 NOT|involved_in ISO (PMID:27010503) RGD PMID:27010503 NCBI chr16:18,109,865...18,116,999
Ensembl chr16:18,110,476...18,114,244 		JBrowse link
G Clptm1 CLPTM1 regulator of GABA type A receptor forward trafficking involved_in ISO (PMID:9218588) RGD PMID:9218588 NCBI chr 1:88,417,447...88,449,047
Ensembl chr 1:88,417,447...88,449,446 		JBrowse link
G Foxn1 forkhead box N1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5297717 (PMID:22072979) 		Ensembl
RGD		 PMID:22072979 GO_REF:0000107 NCBI chr10:63,749,461...63,778,468
Ensembl chr10:63,749,461...63,771,771 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:25065622) RGD PMID:25065622 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:64,405,044...64,428,070 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 acts_upstream_of_or_within
involved_in 		IEA
ISO 		GO_REF:0000107
MGI:98355 (PMID:24043312)
GO_REF:0000117 		Ensembl
RGD
UniProt		 PMID:24043312 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000117
MGI:98354 (PMID:24043312) 		UniProt
RGD		 PMID:24043312 GO_REF:0000117 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 acts_upstream_of_or_within ISO MGI:1857515|MGI:1857799 (PMID:9126927), (PMID:9389660) RGD PMID:9126927 PMID:9389660 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745 		JBrowse link
thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3039682 (PMID:12867038) 		Ensembl
RGD		 PMID:12867038 GO_REF:0000107 NCBI chr12:18,735,088...18,872,045
Ensembl chr12:18,735,088...18,872,045 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2683927 (PMID:14670303) 		Ensembl
RGD		 PMID:14670303 GO_REF:0000107 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2680720 (PMID:14517551) 		Ensembl
RGD		 PMID:14517551 GO_REF:0000107 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:94,601,167...94,696,179 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 involved_in ISS
ISO
IEA 		PMID:10383933
(PMID:10383933)
GO_REF:0000107 		RGD
Ensembl		 PMID:10383933 PMID:10383933 GO_REF:0000107, RGD:8553281 NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:137,804,133...137,826,738 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2677447|MGI:3526403 (PMID:9208839) 		Ensembl
RGD		 PMID:9208839 GO_REF:0000107 NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:46,485,598...46,509,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2920
      leukocyte activation 1068
        lymphocyte activation 867
          lymphocyte differentiation 454
            T cell differentiation 337
              T cell differentiation in thymus 98
                DN2 thymocyte differentiation 2
                DN3 thymocyte differentiation 1
                DN4 thymocyte differentiation 3
                immature T cell proliferation in thymus + 15
                negative regulation of T cell differentiation in thymus + 12
                positive regulation of T cell differentiation in thymus + 9
                regulation of T cell differentiation in thymus + 28
                thymic T cell selection + 28
Path 2
Term Annotations click to browse term
  biological_process 19315
    developmental process 7255
      cellular developmental process 4933
        cell differentiation 4932
          cell development 3418
            hemopoiesis 1096
              leukocyte differentiation 699
                mononuclear cell differentiation 559
                  lymphocyte differentiation 454
                    T cell differentiation 337
                      T cell differentiation in thymus 98
                        DN2 thymocyte differentiation 2
                        DN3 thymocyte differentiation 1
                        DN4 thymocyte differentiation 3
                        immature T cell proliferation in thymus + 15
                        negative regulation of T cell differentiation in thymus + 12
                        positive regulation of T cell differentiation in thymus + 9
                        regulation of T cell differentiation in thymus + 28
                        thymic T cell selection + 28
paths to the root