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ONTOLOGY REPORT - ANNOTATIONS


Term:mast cell homeostasis
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Accession:GO:0033023 term browser browse the term
Definition:The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Comment:Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus.



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mast cell homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:29155995)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:29155995 GO_REF:0000024 GO_REF:0000107 NCBI chr12:29,048,634...29,082,480 JBrowse link
mast cell apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1g Fc epsilon receptor Ig acts_upstream_of ISO MGI:2384004 (PMID:14764707) RGD PMID:14764707 NCBI chr13:83,649,447...83,654,248 JBrowse link
G Il3 interleukin 3 acts_upstream_of ISO (PMID:12714518) RGD PMID:12714518 NCBI chr10:38,405,716...38,408,066 JBrowse link
G Kitlg KIT ligand acts_upstream_of ISO (PMID:12714518) RGD PMID:12714518 NCBI chr 7:34,896,075...34,977,215 JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
MGI:96974|MGI:97583|MGI:99255 (PMID:15039234)
Ensembl
RGD
PMID:15039234 GO_REF:0000107 NCBI chr10:64,306,027...64,539,112 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of ISO MGI:1857249 (PMID:15947484) RGD PMID:15947484 NCBI chr10:85,785,537...85,809,869 JBrowse link
negative regulation of mast cell apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1g Fc epsilon receptor Ig acts_upstream_of_or_within ISO MGI:2384004 (PMID:14764707) RGD PMID:14764707 NCBI chr13:83,649,447...83,654,248 JBrowse link
G Il3 interleukin 3 acts_upstream_of_or_within ISO (PMID:12714518) RGD PMID:12714518 NCBI chr10:38,405,716...38,408,066 JBrowse link
G Kitlg KIT ligand acts_upstream_of_or_within ISO (PMID:12714518) RGD PMID:12714518 NCBI chr 7:34,896,075...34,977,215 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:1857249 (PMID:15947484) RGD PMID:15947484 NCBI chr10:85,785,537...85,809,869 JBrowse link
positive regulation of mast cell apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96974|MGI:97583|MGI:99255 (PMID:15039234)
Ensembl
RGD
PMID:15039234 GO_REF:0000107 NCBI chr10:64,306,027...64,539,112 JBrowse link
regulation of mast cell apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO (PMID:14625290) RGD PMID:14625290 NCBI chr 6:46,601,583...46,663,690 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    immune system process 3112
      leukocyte homeostasis 141
        mast cell homeostasis 7
          mast cell apoptotic process + 6
Path 2
Term Annotations click to browse term
  biological_process 20536
    homeostatic process 2014
      multicellular organismal-level homeostasis 975
        homeostasis of number of cells 428
          leukocyte homeostasis 141
            mast cell homeostasis 7
              mast cell apoptotic process + 6
paths to the root