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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of natural killer cell activation
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Accession:GO:0032814 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of natural killer cell activation.
Synonyms:exact_synonym: regulation of NK cell activation



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regulation of natural killer cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dcaf15 DDB1 and CUL4 associated factor 15 involved_in ISO (PMID:31452512) RGD PMID:31452512 NCBI chr19:24,053,925...24,061,277 JBrowse link
G Lep leptin involved_in ISO
ISS
(PMID:12504075)
GO_REF:0000024
RGD
UniProt
PMID:12504075 GO_REF:0000024 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of_or_within ISO MGI:1922595 (PMID:19151721) RGD PMID:19151721 NCBI chr13:82,437,418...82,461,511 JBrowse link
G Slamf7 SLAM family member 7 acts_upstream_of_or_within ISO MGI:3622649 (PMID:19151721) RGD PMID:19151721 NCBI chr13:86,668,060...86,688,222 JBrowse link
negative regulation of natural killer cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec12a C-type lectin domain family 12, member A involved_in ISO (PMID:15238421), (PMID:31269448)
(PMID:31269448)
RGD PMID:15238421 PMID:31269448 NCBI chr 4:162,798,125...162,816,757 JBrowse link
G Clnk cytokine-dependent hematopoietic cell linker involved_in ISO (PMID:15199160), (PMID:16439675) RGD PMID:15199160 PMID:16439675 NCBI chr14:71,923,894...72,101,180 JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:16439675) RGD PMID:16439675 NCBI chr 5:150,473,767...150,503,524 JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:25337993) RGD PMID:25337993 NCBI chr10:30,882,484...30,914,018 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:64,405,044...64,428,249 JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in ISO (PMID:20068167) RGD PMID:20068167 NCBI chr 1:78,372,798...78,398,932 JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:12516630) RGD PMID:12516630 NCBI chr15:82,258,243...82,427,546 JBrowse link
G Rhbdd3 rhomboid domain containing 3 acts_upstream_of_or_within ISO MGI:5516031 (PMID:23610400) RGD PMID:23610400 NCBI chr14:79,994,111...80,000,294 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:37264229) RGD PMID:37264229 NCBI chr20:4,870,939...4,910,183 JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2670590 (PMID:20709292)
Ensembl
RGD
PMID:20709292 GO_REF:0000107 NCBI chr 1:78,531,815...78,537,001 JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within ISO MGI:5297105 (PMID:20709292) RGD PMID:20709292 NCBI chr 7:11,418,674...11,432,162 JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 acts_upstream_of_or_within ISO MGI:5297106 (PMID:20709292) RGD PMID:20709292 NCBI chr 2:177,479,693...177,490,769 JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO MGI:5297107 (PMID:20709292) RGD PMID:20709292 NCBI chr 2:176,202,654...176,322,859 JBrowse link
positive regulation of natural killer cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s3 biogenesis of lysosomal organelles complex-1, subunit 3 acts_upstream_of_or_within ISO MGI:1857021 (PMID:7089489) RGD PMID:7089489 NCBI chr 1:79,155,873...79,158,247 JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 acts_upstream_of_or_within ISO MGI:1856982 (PMID:7089489) RGD PMID:7089489 NCBI chr 3:109,816,397...109,826,528 JBrowse link
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 acts_upstream_of_or_within ISO MGI:1856712 (PMID:7089489) RGD PMID:7089489 NCBI chr 1:241,551,180...241,577,292 JBrowse link
G Il12a interleukin 12A involved_in ISO
IEA
(PMID:1674604)
GO_REF:0000107
RGD
Ensembl
PMID:1674604 GO_REF:0000107 NCBI chr 2:155,275,734...155,282,997 JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:1674604) RGD PMID:1674604 NCBI chr10:29,390,300...29,405,194 JBrowse link
G Lyst lysosomal trafficking regulator acts_upstream_of_or_within ISO MGI:1855968 (PMID:7089489) RGD PMID:7089489 NCBI chr17:86,241,384...86,443,501 JBrowse link
G Mir130a microRNA 130a involved_in ISO (PMID:31883616) RGD PMID:31883616 NCBI chr 3:69,822,542...69,822,629 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (PMID:21957144) RGD PMID:21957144 NCBI chr 3:124,624,039...124,684,079 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:37264229) RGD PMID:37264229 NCBI chr20:4,870,939...4,910,183 JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 acts_upstream_of_or_within ISO MGI:3701472 (PMID:21059856) RGD PMID:21059856 NCBI chr 9:1,102,559...1,111,023 JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in IBA
ISO
GO_REF:0000033
(PMID:9647200)
GO_Central
RGD
PMID:9647200 GO_REF:0000033 NCBI chr 1:85,672,931...85,676,856 JBrowse link
G Ulbp1 UL16 binding protein 1 acts_upstream_of_or_within ISO (PMID:12645935) RGD PMID:12645935 NCBI chr 1:3,506,106...3,527,982 JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:90,392,864...90,424,123 JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO MGI:2158499 (PMID:14607906) RGD PMID:14607906 NCBI chr 1:104,751,518...104,756,925 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:18840707)
UniProt
RGD
PMID:18840707 GO_REF:0000024 NCBI chr16:82,747,676...82,778,090 JBrowse link
G Il15 interleukin 15 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1931086|MGI:2136897 (PMID:14607906), (PMID:17318811)
Ensembl
RGD
PMID:14607906 PMID:17318811 GO_REF:0000107 NCBI chr19:42,536,160...42,611,349 JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1934016 (PMID:14607906) RGD PMID:14607906 NCBI chr17:66,802,300...66,831,973 JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (PMID:14764669) RGD PMID:14764669 NCBI chr 2:120,117,105...120,127,012 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:21957144)
Ensembl
RGD
PMID:21957144 GO_REF:0000107 NCBI chr 3:124,624,039...124,684,079 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:1857249 (PMID:9841920) RGD PMID:9841920 NCBI chr10:86,285,859...86,310,187 JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181592 (PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107 NCBI chr10:85,704,841...85,775,856 JBrowse link
G Tox thymocyte selection-associated high mobility group box acts_upstream_of_or_within ISO MGI:3773716 (PMID:20818394) RGD PMID:20818394 NCBI chr 5:19,874,994...20,171,272 JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (PMID:22753936) RGD PMID:22753936 NCBI chr 6:95,096,838...95,125,811 JBrowse link
positive regulation of natural killer cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd244 CD244 molecule involved_in ISO (PMID:15905190) RGD PMID:15905190 NCBI chr13:84,051,339...84,082,864 JBrowse link
G Fcgr3a Fc gamma receptor 3A involved_in ISO (PMID:9916693) RGD PMID:9916693 NCBI chr13:85,782,636...85,792,656 JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand IDA RGD PMID:16528542 RGD:11049499 NCBI chr 1:104,751,518...104,756,925 JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:29,390,300...29,405,194 JBrowse link
G Il15 interleukin 15 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:14607906)
Ensembl
RGD
PMID:14607906 GO_REF:0000107 NCBI chr19:42,536,160...42,611,349 JBrowse link
G Il18 interleukin 18 involved_in ISO
IEA
(PMID:19088061)
GO_REF:0000107
RGD
Ensembl
PMID:19088061 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:1,306,320...1,308,434 JBrowse link
G Jak2 Janus kinase 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 1:236,408,905...236,468,769 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:30134159) RGD PMID:30134159 NCBI chr20:4,870,939...4,910,183 JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181592 (PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107 NCBI chr10:85,704,841...85,775,856 JBrowse link
G Tyk2 tyrosine kinase 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 8:27,918,054...27,943,319 JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:64,405,044...64,428,249 JBrowse link
G Prdm1 PR/SET domain 1 involved_in ISO (PMID:27102484) RGD PMID:27102484 NCBI chr20:47,959,858...47,981,488 JBrowse link
G Zfp683 zinc finger protein 683 involved_in ISO (PMID:27102484) RGD PMID:27102484 NCBI chr 5:146,277,972...146,285,856 JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp683 zinc finger protein 683 involved_in ISO (PMID:22885984) RGD PMID:22885984 NCBI chr 5:146,277,972...146,285,856 JBrowse link
regulation of natural killer cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lep leptin involved_in ISO
ISS
(PMID:12504075)
GO_REF:0000024
RGD
UniProt
PMID:12504075 GO_REF:0000024 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO
ISS
(PMID:20522204)
GO_REF:0000024
RGD
BHF-UCL
PMID:20522204 GO_REF:0000024 NCBI chr 2:191,366,761...191,414,782 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    immune system process 3112
      regulation of immune system process 1732
        regulation of leukocyte activation 606
          regulation of lymphocyte activation 523
            regulation of natural killer cell activation 47
              negative regulation of natural killer cell activation + 13
              positive regulation of natural killer cell activation + 28
              regulation of natural killer cell differentiation + 18
              regulation of natural killer cell proliferation + 13
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        regulation of cellular process 13013
          regulation of cell activation 663
            regulation of leukocyte activation 606
              regulation of lymphocyte activation 523
                regulation of natural killer cell activation 47
                  negative regulation of natural killer cell activation + 13
                  positive regulation of natural killer cell activation + 28
                  regulation of natural killer cell differentiation + 18
                  regulation of natural killer cell proliferation + 13
paths to the root