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ONTOLOGY REPORT - ANNOTATIONS


Term:DSIF complex
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Accession:GO:0032044 term browser browse the term
Definition:A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
Synonyms:exact_synonym: 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex;   DRB sensitivity inducing factor complex;   Spt4-Spt5 complex



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DSIF complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit part_of IBA
ISO
GO_REF:0000033
(PMID:19860741), (PMID:9450929)
GO_Central
RGD
PMID:9450929 PMID:19860741 GO_REF:0000033 NCBI chr10:72,539,323...72,545,582
Ensembl chr10:72,539,382...72,545,831
JBrowse link
G Supt5h SPT5 homolog, DSIF elongation factor subunit part_of IBA
ISO
GO_REF:0000033
(PMID:19860741), (PMID:9450929)
GO_Central
RGD
PMID:9450929 PMID:19860741 GO_REF:0000033 NCBI chr 1:83,586,713...83,616,971
Ensembl chr 1:83,586,718...83,616,892
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  cellular_component 20824
    cellular anatomical structure 20625
      nucleoplasm 3547
        transcription elongation factor complex 71
          DSIF complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20824
    cellular anatomical structure 20625
      intracellular anatomical structure 15180
        intracellular organelle 13561
          intracellular membrane-bounded organelle 12003
            nucleus 7451
              nuclear lumen 4053
                nucleoplasm 3547
                  transcription elongation factor complex 71
                    DSIF complex 2
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