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ONTOLOGY REPORT - ANNOTATIONS


Term:protein destabilization
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Accession:GO:0031648 term browser browse the term
Definition:Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
Synonyms:exact_synonym: negative regulation of protein stability;   protein destabilisation



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protein destabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96396 (PMID:15322112)
Ensembl
RGD
PMID:15322112 GO_REF:0000107 NCBI chr 3:141,264,648...141,275,416 JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase involved_in ISO (PMID:16885022) RGD PMID:16885022 NCBI chr 1:244,210,299...244,380,126 JBrowse link
G Capn3 calpain 3 involved_in IEA
ISO
GO_REF:0000107
(PMID:23357851)
Ensembl
RGD
PMID:23357851 GO_REF:0000107 NCBI chr 3:127,860,002...127,913,677 JBrowse link
G Ccdc88c coiled-coil domain containing 88C involved_in ISO (PMID:14750955) RGD PMID:14750955 NCBI chr 6:120,169,752...120,289,459 JBrowse link
G Cdc73 cell division cycle 73 involved_in ISO
IEA
(PMID:18987311)
GO_REF:0000107
RGD
Ensembl
PMID:18987311 GO_REF:0000107 NCBI chr13:55,357,226...55,449,690 JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:9529249) RGD PMID:9529249 NCBI chr 5:109,100,763...109,114,448 JBrowse link
G Chfr checkpoint with forkhead and ring finger domains acts_upstream_of_or_within ISO (PMID:22285184) RGD PMID:22285184 NCBI chr12:46,504,497...46,538,104 JBrowse link
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:36822331) RGD PMID:36822331 NCBI chr10:5,434,725...5,631,246 JBrowse link
G Commd1 copper metabolism domain containing 1 acts_upstream_of_or_within ISO MGI:3714157 (PMID:17371845) RGD PMID:17371845 NCBI chr14:101,081,667...101,185,738 JBrowse link
G Crebbp CREB binding protein involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:24939902)
Ensembl
UniProt
RGD
PMID:24939902 GO_REF:0000024 GO_REF:0000107 NCBI chr10:11,842,307...11,968,266 JBrowse link
G Ctsh cathepsin H involved_in ISO
ISS
IEA
(PMID:17500053)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:17500053 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:99,488,756...99,507,639 JBrowse link
G Cul3 cullin 3 involved_in ISO
IEA
RNAcentral:URS00001230A0_9606 (PMID:24844779)
GO_REF:0000107
RGD
Ensembl
PMID:24844779 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428 JBrowse link
G Dazap2 DAZ associated protein 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:33591310)
UniProt
RGD
PMID:33591310 GO_REF:0000024 NCBI chr 7:131,714,749...131,720,266 JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:89,404,413...89,427,095 JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:24939902) RGD PMID:24939902 NCBI chr 7:114,987,857...115,058,652 JBrowse link
G Fbxl3 F-box and leucine-rich repeat protein 3 involved_in ISO (PMID:23616524) RGD PMID:23616524 NCBI chr15:79,906,795...79,926,678 JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO MGI:5301830 (PMID:21911473) RGD PMID:21911473 NCBI chr 2:53,174,798...53,187,792 JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 involved_in ISO (PMID:16885022) RGD PMID:16885022 NCBI chr10:17,232,735...17,330,574 JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 acts_upstream_of_or_within ISO (PMID:18625840) RGD PMID:18625840 NCBI chr 2:170,149,706...170,311,536 JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:20484053) RGD PMID:20484053 NCBI chr10:100,825,427...100,843,422 JBrowse link
G Gsn gelsolin involved_in ISO
IEA
(PMID:19549824)
GO_REF:0000107
RGD
Ensembl
PMID:19549824 GO_REF:0000107 NCBI chr 3:38,982,605...39,035,849 JBrowse link
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:24882211) RGD PMID:24882211 NCBI chr  X:14,550,645...14,572,445 JBrowse link
G Htt huntingtin involved_in ISO
IEA
(PMID:17947297)
GO_REF:0000107
RGD
Ensembl
PMID:17947297 GO_REF:0000107 NCBI chr14:75,845,836...75,996,094 JBrowse link
G Iapp islet amyloid polypeptide involved_in ISO (PMID:22944668) RGD PMID:22944668 NCBI chr 4:175,237,107...175,244,373 JBrowse link
G Id1 inhibitor of DNA binding 1 acts_upstream_of_or_within ISO MGI:88177 (PMID:15322112) RGD PMID:15322112 NCBI chr 3:161,671,525...161,672,691 JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:25891078) RGD PMID:25891078 NCBI chr10:33,233,513...33,241,594 JBrowse link
G Isoc2b isochorismatase domain containing 2b involved_in ISO (PMID:17658461) RGD PMID:17658461 NCBI chr 1:68,972,960...68,993,760 JBrowse link
G Kdm8 lysine demethylase 8 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:30500822)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30500822 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:180,013,969...180,028,829 JBrowse link
G Klf1 KLF transcription factor 1 involved_in ISO (PMID:24139988) RGD PMID:24139988 NCBI chr19:23,250,627...23,253,802 JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:10360174), (PMID:15314173), (PMID:16479015), (PMID:18560357), (PMID:9529249) RGD PMID:9529249 PMID:10360174 PMID:15314173 PMID:16479015 PMID:18560357 NCBI chr 7:55,176,558...55,201,757 JBrowse link
G Mtmr1 myotubularin related protein 1 involved_in ISO (PMID:33053349) RGD PMID:33053349 NCBI chr18:215,031...248,541 JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO
GO_REF:0000107
(PMID:36608670)
Ensembl
RGD
PMID:36608670 GO_REF:0000107 NCBI chr 5:164,167,985...164,277,438 JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:24898855) RGD PMID:24898855 NCBI chr 5:150,652,812...150,661,863 JBrowse link
G Mylip myosin regulatory light chain interacting protein involved_in ISO (PMID:19520913) RGD PMID:19520913 NCBI chr17:19,286,649...19,308,295 JBrowse link
G Npm1 nucleophosmin 1 acts_upstream_of_or_within ISO RGD MGI:62033 NCBI chr10:17,741,512...17,751,626 JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:27686098)
Ensembl
UniProt
RGD
PMID:27686098 GO_REF:0000024 GO_REF:0000107 NCBI chr10:84,224,599...84,231,812 JBrowse link
G Pex2 peroxisomal biogenesis factor 2 involved_in ISO
IEA
(PMID:18987311)
GO_REF:0000107
RGD
Ensembl
PMID:18987311 GO_REF:0000107 NCBI chr 2:96,050,380...96,072,928 JBrowse link
G Plk1 polo-like kinase 1 involved_in ISO
IEA
(PMID:16885022)
GO_REF:0000107
RGD
Ensembl
PMID:16885022 GO_REF:0000107 NCBI chr 1:186,147,658...186,157,637 JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:15194694) RGD PMID:15194694 NCBI chr11:98,544,952...98,762,499 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
ISS
IEA
(PMID:19591802), (PMID:29311685)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:19591802 PMID:29311685 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242 JBrowse link
G Prnp prion protein involved_in ISO (PMID:20564047) RGD PMID:20564047 NCBI chr 3:139,639,076...139,654,420 JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein involved_in ISO (PMID:26296656) RGD PMID:26296656 NCBI chr19:23,313,563...23,320,702 JBrowse link
G Rnf139 ring finger protein 139 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:90,439,726...90,450,911 JBrowse link
G Rnf5 ring finger protein 5 acts_upstream_of_or_within ISO (PMID:23093945) RGD PMID:23093945 NCBI chr20:4,145,539...4,147,985 JBrowse link
G Senp2 SUMO specific peptidase 2 involved_in ISO (PMID:22028379) RGD PMID:22028379 NCBI chr11:78,981,429...79,018,274 JBrowse link
G Serf1 small EDRK-rich factor 1 involved_in ISO (PMID:20723760), (PMID:22854022), (PMID:31034892) RGD PMID:20723760 PMID:22854022 PMID:31034892 NCBI chr 2:31,475,902...31,482,030 JBrowse link
G Serf2 small EDRK-rich factor 2 involved_in ISO (PMID:20723760) RGD PMID:20723760 NCBI chr 3:108,426,960...108,430,736 JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 IMP synaptophysin RGD PMID:2129524 RGD:727236 NCBI chr19:36,552,165...36,575,773 JBrowse link
G Sirt1 sirtuin 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:17936707)
Ensembl
RGD
PMID:17936707 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:29474172)
(PMID:20141841)
RGD PMID:20141841 PMID:29474172 NCBI chr 7:8,082,312...8,087,776 JBrowse link
G Snca synuclein alpha involved_in ISO
IEA
(PMID:21320589)
GO_REF:0000107
RGD
Ensembl
PMID:21320589 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444 JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (PMID:17875931) RGD PMID:17875931 NCBI chr 5:15,016,660...15,022,228 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:25259869) RGD PMID:25259869 NCBI chr 3:166,511,616...166,559,463 JBrowse link
G Trim21 tripartite motif-containing 21 involved_in ISO (PMID:16880511) RGD PMID:16880511 NCBI chr 1:156,964,896...156,987,504 JBrowse link
G Utp25 UTP25 small subunit processome component involved_in ISO
ISS
(PMID:23357851)
GO_REF:0000024
RGD
UniProt
PMID:23357851 GO_REF:0000024 NCBI chr13:104,630,390...104,651,681 JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26203154) RGD PMID:26203154 NCBI chr19:21,765,771...21,801,620 JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS
IEA
(PMID:25280941)
(PMID:16461360), (PMID:25239945)
GO_REF:0000024
(PMID:24753614)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:16461360 PMID:24753614 PMID:25239945 PMID:25280941 GO_REF:0000024 GO_REF:0000107 NCBI chr14:84,604,623...84,609,707 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological quality 3448
        regulation of protein stability 365
          protein destabilization 57
paths to the root