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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell costimulation
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Accession:GO:0031295 term browser browse the term
Definition:The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
Synonyms:exact_synonym: T cell co-stimulation;   T lymphocyte costimulation
 xref: Reactome:R-HSA-388841 "Costimulation by the CD28 family"


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T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 involved_in ISO
IEA		 (PMID:17287217)
GO_REF:0000107		 RGD
Ensembl		 PMID:17287217 GO_REF:0000107 NCBI chr12:18,735,088...18,872,045
Ensembl chr12:13,621,087...13,758,112 		JBrowse link
G Cav1 caveolin 1 involved_in ISO
IEA
ISS		 (PMID:17287217)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17287217 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Cd160 CD160 molecule involved_in ISO
IEA		 (PMID:11978774), (PMID:9973372)
GO_REF:0000107		 RGD
Ensembl		 PMID:9973372 PMID:11978774 GO_REF:0000107 NCBI chr 2:187,029,654...187,042,447
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
G Cd24 CD24 molecule involved_in ISS
ISO		 PMID:11272271
(PMID:11272271)
GO_REF:0000024		 RGD
UniProt		 PMID:11272271 PMID:11272271 GO_REF:0000024, RGD:8554145 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd274 CD274 molecule involved_in ISO
IBA		 (PMID:10581077)
GO_REF:0000033		 RGD
GO_Central		 PMID:10581077 GO_REF:0000033 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA		 MGI:1857150|MGI:88332 (PMID:10429671), (PMID:12925852), (PMID:15240667), (PMID:23793062), (PMID:7688139), (PMID:8125140), (PMID:9368605)
GO_REF:0000033		 RGD
GO_Central		 PMID:7688139 PMID:8125140 PMID:9368605 PMID:10429671 PMID:12925852 More... GO_REF:0000033, RGD:2303155 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO MGI:88327 (PMID:23793062) RGD PMID:23793062 NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd5 Cd5 molecule involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:10429671)		 GO_Central
Ensembl
RGD		 PMID:10429671 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:216,790,245...216,811,209
Ensembl chr 1:207,365,337...207,386,313 		JBrowse link
G Cd80 Cd80 molecule involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000002
(PMID:1385153), (PMID:15568026)		 GO_Central
InterPro
RGD		 PMID:1385153 PMID:15568026 GO_REF:0000002 GO_REF:0000033 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 involved_in ISO
ISS		 (PMID:10900005), (PMID:17287217)
GO_REF:0000024		 RGD
UniProt		 PMID:10900005 PMID:17287217 GO_REF:0000024 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Efnb1 ephrin B1 acts_upstream_of_or_within ISO
IEA		 (PMID:15599401)
GO_REF:0000107		 RGD
Ensembl		 PMID:15599401 GO_REF:0000107 NCBI chr  X:68,297,529...68,310,335
Ensembl chr  X:64,257,351...64,270,157 		JBrowse link
G Efnb2 ephrin B2 acts_upstream_of_or_within ISO
IEA		 (PMID:15599401)
GO_REF:0000107		 RGD
Ensembl		 PMID:15599401 GO_REF:0000107 NCBI chr16:87,485,215...87,529,224
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Efnb3 ephrin B3 acts_upstream_of_or_within ISO (PMID:15599401) RGD PMID:15599401 NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,274,506...54,280,471 		JBrowse link
G Hhla2 HHLA2 member of B7 family involved_in ISO (PMID:23784006) RGD PMID:23784006 NCBI chr11:64,726,345...64,740,139 JBrowse link
G Icos inducible T-cell co-stimulator involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:11006126 GO_REF:0000002 GO_REF:0000033, RGD:631942 NCBI chr 9:69,862,042...69,900,864
Ensembl chr 9:62,383,832...62,405,672 		JBrowse link
G Lgals1 galectin 1 acts_upstream_of_or_within ISO
IEA		 (PMID:22357632)
GO_REF:0000107		 RGD
Ensembl		 PMID:22357632 GO_REF:0000107 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lgals8 galectin 8 acts_upstream_of_or_within ISO
IEA		 (PMID:22357632)
GO_REF:0000107		 RGD
Ensembl		 PMID:22357632 GO_REF:0000107 NCBI chr17:62,716,368...62,744,272
Ensembl chr17:58,028,105...58,052,764 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:236,572,497...236,637,490
Ensembl chr 1:227,158,941...227,223,938 		JBrowse link
G Spn sialophorin acts_upstream_of_or_within ISO (PMID:10429671), (PMID:11380685), (PMID:7790813) RGD PMID:7790813 PMID:10429671 PMID:11380685 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2389403 (PMID:15240667), (PMID:15368291)		 GO_Central
RGD		 PMID:15240667 PMID:15368291 GO_REF:0000033 NCBI chr 7:115,616,139...115,618,647
Ensembl chr 7:113,736,055...113,738,517 		JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 involved_in ISO (PMID:10754304) RGD PMID:10754304 NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:165,484,262...165,493,703 		JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of_or_within ISO
IEA		 (PMID:15240667), (PMID:15368291)
GO_REF:0000107		 RGD
Ensembl		 PMID:15240667 PMID:15368291 GO_REF:0000107 NCBI chr16:86,164,377...86,195,072
Ensembl chr16:79,462,402...79,492,693 		JBrowse link
G Tnfsf14 TNF superfamily member 14 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:10754304)
GO_REF:0000107
(PMID:15568026)		 RGD
Ensembl		 PMID:10754304 PMID:15568026 GO_REF:0000107 NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,069,104...2,073,216 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 involved_in ISO
IEA		 (PMID:8484124)
GO_REF:0000107		 RGD
Ensembl		 PMID:8484124 GO_REF:0000107 NCBI chr 9:2,248,856...2,295,905
Ensembl chr 9:2,157,900...2,208,937 		JBrowse link
CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISO
ISS		 (PMID:22307619)
GO_REF:0000024		 RGD
UniProt		 PMID:22307619 GO_REF:0000024 NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO
IEA		 (PMID:20639485)
GO_REF:0000107		 RGD
Ensembl		 PMID:20639485 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd160 CD160 molecule involved_in ISO
IEA		 (PMID:18193050)
GO_REF:0000107		 RGD
Ensembl		 PMID:18193050 GO_REF:0000107 NCBI chr 2:187,029,654...187,042,447
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
negative regulation of T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:17163451) RGD PMID:17163451 NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
positive regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO
IEA		 (PMID:20639485)
GO_REF:0000107		 RGD
Ensembl		 PMID:20639485 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO
IEA		 (PMID:15845453)
GO_REF:0000107		 RGD
Ensembl		 PMID:15845453 GO_REF:0000107 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Ephb4 EPH receptor B4 acts_upstream_of_or_within ISO MGI:1096338 (PMID:15599401) RGD PMID:15599401 NCBI chr12:24,963,174...24,988,473
Ensembl chr12:19,326,427...19,351,314 		JBrowse link
G Ephb6 Eph receptor B6 acts_upstream_of_or_within ISO
IEA		 MGI:104757 (PMID:15599401)
GO_REF:0000107		 RGD
Ensembl		 PMID:15599401 GO_REF:0000107 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO
IEA		 (PMID:20639485)
GO_REF:0000107		 RGD
Ensembl		 PMID:20639485 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      lymphocyte costimulation 36
        T cell costimulation 33
          CD4-positive, alpha-beta T cell costimulation + 3
          negative regulation of T cell costimulation + 2
          positive regulation of T cell costimulation + 4
          regulation of T cell costimulation + 6
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        regulation of cellular process 13030
          regulation of cell activation 667
            regulation of leukocyte activation 609
              positive regulation of leukocyte activation 358
                positive regulation of lymphocyte activation 318
                  lymphocyte costimulation 36
                    T cell costimulation 33
                      CD4-positive, alpha-beta T cell costimulation + 3
                      negative regulation of T cell costimulation + 2
                      positive regulation of T cell costimulation + 4
                      regulation of T cell costimulation + 6
paths to the root