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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA replication preinitiation complex
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Accession:GO:0031261 term browser browse the term
Definition:A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
Synonyms:exact_synonym: pre-IC


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DNA replication preinitiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc45 cell division cycle 45 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Orc3 origin recognition complex, subunit 3 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:49,123,758...49,181,552
Ensembl chr 5:49,126,955...49,181,633 		JBrowse link
CMG complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc45 cell division cycle 45 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Gins1 GINS complex subunit 1 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936 		JBrowse link
G Gins2 GINS complex subunit 2 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339 		JBrowse link
G Gins3 GINS complex subunit 3 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687 		JBrowse link
G Gins4 GINS complex subunit 4 part_of ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22474384)		 UniProt
Ensembl
RGD		 PMID:22474384 GO_REF:0000024 GO_REF:0000107 NCBI chr16:68,787,572...68,799,938
Ensembl chr16:68,767,339...68,802,273 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 part_of ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22474384)		 UniProt
Ensembl
RGD		 PMID:22474384 GO_REF:0000024 GO_REF:0000107 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 part_of ISO (PMID:22474384) RGD PMID:22474384 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
GINS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gins1 GINS complex subunit 1 part_of IBA
ISO		 GO_REF:0000033
(PMID:17417653)		 GO_Central
RGD		 PMID:17417653 GO_REF:0000033 NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936 		JBrowse link
G Gins2 GINS complex subunit 2 part_of IBA
ISO		 GO_REF:0000033
(PMID:17417653)		 GO_Central
RGD		 PMID:17417653 GO_REF:0000033 NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339 		JBrowse link
G Gins3 GINS complex subunit 3 part_of IBA
ISO		 GO_REF:0000033
(PMID:17417653)		 GO_Central
RGD		 PMID:17417653 GO_REF:0000033 NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687 		JBrowse link
G Gins4 GINS complex subunit 4 part_of IEA
ISO
IBA		 GO_REF:0000107
(PMID:17417653)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:17417653 GO_REF:0000033 GO_REF:0000107 NCBI chr16:68,787,572...68,799,938
Ensembl chr16:68,767,339...68,802,273 		JBrowse link
G Slc5a8 solute carrier family 5 member 8 part_of ISO (MGI:4837076|PMID:20211600)
(PMID:20211600)		 RGD PMID:20211600 MGI:4837076 NCBI chr 7:23,272,891...23,313,811
Ensembl chr 7:23,272,427...23,314,642 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20814
    protein-containing complex 6438
      nuclear protein-containing complex 1306
        DNA replication preinitiation complex 13
          CMG complex 11
          GINS complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      organelle 14007
        intracellular organelle 13599
          intracellular membrane-bounded organelle 12057
            nucleus 7485
              nuclear lumen 4086
                nucleoplasm 3587
                  DNA replication preinitiation complex 13
                    CMG complex 11
                    GINS complex 5
paths to the root