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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule
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Accession:GO:0031045 term browser browse the term
Definition:Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.
Synonyms:exact_synonym: dense core vesicle
 xref: NIF_Subcellular:sao772007592


show annotations for term's descendants           Sort by:
dense core granule term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bace2 beta-secretase 2 IDA MMO:0000663 RGD PMID:19117266 RGD:13782168 NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Baiap3 BAI1-associated protein 3 NOT|located_in ISO (PMID:28626000) RGD PMID:28626000 NCBI chr10:14,764,768...14,777,516
Ensembl chr10:14,260,269...14,273,019 		JBrowse link
G Cadps calcium dependent secretion activator located_in IDA PMID:24356451 ParkinsonsUK-UCL PMID:24356451 RGD:11535098 NCBI chr15:14,719,078...15,173,218
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Cpe carboxypeptidase E IDA RGD PMID:19553464 RGD:6483099 NCBI chr16:29,796,707...29,908,647
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein IDA RGD PMID:10524337 RGD:5490549 NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:26,692,403...26,704,710 		JBrowse link
G Ecrg4 ECRG4 augurin precursor located_in ISO
ISS		 (PMID:17284679) RGD PMID:17284679 PMID:17284679 RGD:12907558 NCBI chr 9:53,485,040...53,504,691
Ensembl chr 9:45,992,954...46,012,595 		JBrowse link
G Myrip myosin VIIA and Rab interacting protein located_in IDA PMID:17827149 UniProt PMID:17827149 RGD:8554303 NCBI chr 8:128,895,371...129,062,420
Ensembl chr 8:120,017,524...120,183,833 		JBrowse link
G Ncs1 neuronal calcium sensor 1 located_in IDA RGD PMID:9712909 RGD:2316314 NCBI chr 3:34,920,949...34,966,554
Ensembl chr 3:14,523,220...14,568,829 		JBrowse link
G Pdyn prodynorphin IDA RGD PMID:16966485 RGD:401854252 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Scg2 secretogranin II located_in ISO (PMID:14622145) RGD PMID:14622145 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:80,803,075...80,821,097 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 IDA RGD PMID:7568015 RGD:2317337 NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a5 solute carrier family 6 member 5 located_in IDA PMID:12091465 ARUK-UCL PMID:12091465 RGD:30309946 NCBI chr 1:108,767,245...108,833,173
Ensembl chr 1:99,645,389...99,697,010 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 located_in IDA PMID:12091465 ARUK-UCL PMID:12091465 RGD:30309946 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Sod1 superoxide dismutase 1 IDA RGD PMID:17403136 RGD:8657024 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spx spexin hormone located_in ISO
IEA
ISS		 (PMID:17284679)
GO_REF:0000107		 RGD
Ensembl		 PMID:17284679 PMID:17284679 GO_REF:0000107, RGD:12907558 NCBI chr 4:177,087,053...177,093,091
Ensembl chr 4:175,356,247...175,362,082 		JBrowse link
G Syt1 synaptotagmin 1 located_in
is_active_in		 IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:18468511)
GO_REF:0000033
PMID:22366033		 Ensembl
RGD
GO_Central		 PMID:18468511 PMID:11751925 PMID:22366033 PMID:21551071 GO_REF:0000033 GO_REF:0000107, RGD:2311146, RGD:8553894, RGD:7205660 NCBI chr 7:45,699,649...46,244,460
Ensembl chr 7:43,815,785...44,357,803 		JBrowse link
G Syt13 synaptotagmin 13 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:99,332,554...99,372,960
Ensembl chr 3:78,877,114...78,917,392 		JBrowse link
G Syt2 synaptotagmin 2 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:48,639,634...48,749,814
Ensembl chr13:46,185,282...46,193,859 		JBrowse link
G Syt4 synaptotagmin 4 located_in IDA
IEA
ISO		 GO_REF:0000107
(PMID:18468511), (PMID:19136969)
PMID:10217258		 Ensembl
RGD		 PMID:18468511 PMID:19136969 PMID:21551071 PMID:10217258 GO_REF:0000107, RGD:7205660, RGD:11535095 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,038,378...23,046,332 		JBrowse link
G Syt5 synaptotagmin 5 is_active_in
located_in		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:14622145), (PMID:16407767)		 GO_Central
Ensembl
RGD		 PMID:14622145 PMID:16407767 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:69,277,351...69,285,067 		JBrowse link
G Syt7 synaptotagmin 7 IDA RGD PMID:21551071 PMID:20016973 RGD:7205660, RGD:7241272 NCBI chr 1:216,456,148...216,518,718
Ensembl chr 1:207,031,592...207,089,026 		JBrowse link
G Syt8 synaptotagmin 8 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:207,017,602...207,023,076
Ensembl chr 1:197,590,149...197,593,504 		JBrowse link
G Syt9 synaptotagmin 9 located_in
is_active_in		 IDA
ISO
IBA		 (PMID:16407767)
GO_REF:0000033		 RGD
GO_Central		 PMID:16407767 PMID:11751925 PMID:21551071 GO_REF:0000033, RGD:2311146, RGD:7205660 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:161,275,734...161,455,007 		JBrowse link
G Vps13a vacuolar protein sorting 13 homolog A located_in ISO (PMID:22366033) RGD PMID:22366033 NCBI chr 1:223,328,784...223,555,500
Ensembl chr 1:213,901,999...214,128,555 		JBrowse link
dense core granule membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 located_in ISO
IEA		 (PMID:17548643)
GO_REF:0000107		 RGD
Ensembl		 PMID:17548643 GO_REF:0000107 NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Vps13c vacuolar protein sorting 13 homolog C located_in ISO
IEA		 (PMID:27329800)
GO_REF:0000107		 RGD
Ensembl		 PMID:27329800 GO_REF:0000107 NCBI chr 8:77,359,499...77,533,009
Ensembl chr 8:68,478,395...68,651,895 		JBrowse link
extrinsic component of neuronal dense core vesicle membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator is_active_in IDA
IEP		 PMID:9697858 SynGO PMID:9697858 PMID:9697858 RGD:13702263, RGD:13702263 NCBI chr15:14,719,078...15,173,218
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Stxbp5 syntaxin binding protein 5 is_active_in ISO
IEA		 (PMID:28746398)
GO_REF:0000107		 RGD
Ensembl		 PMID:28746398 GO_REF:0000107 NCBI chr 1:6,002,738...6,155,528
Ensembl chr 1:4,185,529...4,335,101 		JBrowse link
neuronal dense core vesicle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 is_active_in ISO (PMID:21321602) RGD PMID:21321602 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 is_active_in ISO
IEA		 (PMID:21321602)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321602 GO_REF:0000107 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G App amyloid beta precursor protein is_active_in IDA PMID:29577889 SynGO PMID:29577889 RGD:155230747 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Avp arginine vasopressin is_active_in IDA PMID:30519837 SynGO PMID:30519837 RGD:155230768 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bdnf brain-derived neurotrophic factor is_active_in ISO (PMID:22412021) RGD PMID:22412021 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 is_active_in ISO
IEA		 (PMID:21321602)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321602 GO_REF:0000107 NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Calca calcitonin-related polypeptide alpha is_active_in IDA PMID:9383204 SynGO PMID:9383204 RGD:155230740 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calcrl calcitonin receptor like receptor is_active_in IDA PMID:17614212 SynGO PMID:17614212 RGD:155230744 NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:69,430,120...69,525,910 		JBrowse link
G Chga chromogranin A located_in IDA
IEA		 PMID:29166604
GO_REF:0000044		 UniProt PMID:29166604 GO_REF:0000044, RGD:15023486 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Dmxl2 Dmx-like 2 is_active_in ISO (PMID:25248098) RGD PMID:25248098 NCBI chr 8:63,637,314...63,803,911
Ensembl chr 8:54,741,160...54,885,161 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 is_active_in ISO
IEA		 (PMID:21321602)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321602 GO_REF:0000107 NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Fzd8 frizzled class receptor 8 is_active_in ISO
IEA		 (PMID:21321602)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321602 GO_REF:0000107 NCBI chr17:62,007,849...62,015,485
Ensembl chr17:57,314,450...57,320,650 		JBrowse link
G Gnai2 G protein subunit alpha i2 is_active_in ISO
IEA		 (PMID:21321602)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321602 GO_REF:0000107 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Grp gastrin releasing peptide is_active_in IDA PMID:2422591 SynGO PMID:2422591 RGD:155230719 NCBI chr18:61,658,655...61,672,037
Ensembl chr18:59,388,274...59,402,061 		JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D is_active_in IDA PMID:14645495 SynGO PMID:14645495 RGD:734519 NCBI chr 5:153,939,735...153,960,012
Ensembl chr 5:148,674,495...148,675,619 		JBrowse link
G Kif1a kinesin family member 1A located_in IDA PMID:29166604
PMID:30021165		 UniProt PMID:29166604 PMID:30021165 RGD:15023486, RGD:14995321 NCBI chr 9:101,010,447...101,094,891
Ensembl chr 9:93,563,045...93,647,480 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor is_active_in IDA PMID:1924889 SynGO PMID:1924889 RGD:2316577 NCBI chr 7:135,533,050...135,533,839 JBrowse link
G Npy neuropeptide Y located_in
is_active_in		 IDA
IEA		 PMID:29166604
GO_REF:0000044
PMID:29775703
PMID:30021165		 UniProt PMID:29166604 PMID:29775703 PMID:30021165 GO_REF:0000044, RGD:15023486, RGD:155230710, RGD:14995321 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 is_active_in IDA PMID:29775703 SynGO PMID:29775703 RGD:155230710 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprd1 opioid receptor, delta 1 is_active_in IDA
IEA
ISO		 PMID:7666182
GO_REF:0000107
(PMID:21321602)		 Ensembl
RGD		 PMID:21321602 PMID:7666182 GO_REF:0000107, RGD:13702250 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide is_active_in IDA PMID:3883189 SynGO PMID:3883189 RGD:405650232 NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G P2rx2 purinergic receptor P2X 2 is_active_in ISO
IEA		 (PMID:21321602)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321602 GO_REF:0000107 NCBI chr12:51,999,107...52,002,627
Ensembl chr12:46,339,549...46,342,891 		JBrowse link
G Pdyn prodynorphin is_active_in ISO
IEA		 (PMID:10098940)
GO_REF:0000107		 RGD
Ensembl		 PMID:10098940 GO_REF:0000107 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Plat plasminogen activator, tissue type is_active_in IDA
IMP		 PMID:21976424 SynGO PMID:21976424 PMID:21976424 RGD:13702320, RGD:13702320 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plcb2 phospholipase C, beta 2 is_active_in ISO
IEA		 (PMID:21321602)
GO_REF:0000107		 RGD
Ensembl		 PMID:21321602 GO_REF:0000107 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Scg2 secretogranin II is_active_in ISO (PMID:1918927), (PMID:21044184) RGD PMID:1918927 PMID:21044184 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:80,803,075...80,821,097 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 is_active_in IDA PMID:8753875 SynGO PMID:8753875 RGD:13702244 NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Sst somatostatin is_active_in IDA PMID:2422591 SynGO PMID:2422591 RGD:155230719 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Stxbp5l syntaxin binding protein 5L is_active_in ISO
IEA		 (PMID:28746398)
GO_REF:0000107		 RGD
Ensembl		 PMID:28746398 GO_REF:0000107 NCBI chr11:76,838,839...77,167,852
Ensembl chr11:63,334,667...63,657,014 		JBrowse link
G Syt4 synaptotagmin 4 located_in IDA PMID:29166604 UniProt PMID:29166604 RGD:15023486 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,038,378...23,046,332 		JBrowse link
G Tac1 tachykinin, precursor 1 is_active_in IDA PMID:6167867 SynGO PMID:6167867 RGD:405650396 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
neuronal dense core vesicle lumen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 is_active_in IDA PMID:9792613 SynGO PMID:9792613 RGD:2312463 NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Cck cholecystokinin is_active_in IDA PMID:6084830 SynGO PMID:6084830 RGD:405650225 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Crh corticotropin releasing hormone is_active_in IDA PMID:19003957 SynGO PMID:19003957 RGD:405650366 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide is_active_in ISO (PMID:12597862) RGD PMID:12597862 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Hcrt hypocretin neuropeptide precursor is_active_in IDA PMID:9419374 SynGO PMID:9419374 RGD:1298943 NCBI chr10:86,190,289...86,191,524
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Igf1 insulin-like growth factor 1 is_active_in ISO (PMID:28683263) RGD PMID:28683263 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Pdyn prodynorphin is_active_in IDA PMID:7911809 SynGO PMID:7911809 RGD:13702229 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin is_active_in IDA PMID:8847409 SynGO PMID:8847409 RGD:13702175 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Vps13a vacuolar protein sorting 13 homolog A located_in ISO (PMID:22366033) RGD PMID:22366033 NCBI chr 1:223,328,784...223,555,500
Ensembl chr 1:213,901,999...214,128,555 		JBrowse link
neuronal dense core vesicle membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr15:14,719,078...15,173,218
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Kif1a kinesin family member 1A located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 9:101,010,447...101,094,891
Ensembl chr 9:93,563,045...93,647,480 		JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N is_active_in IDA PMID:8641276 SynGO PMID:8641276 RGD:10402034 NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:76,741,016...76,756,190 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 is_active_in IDA PMID:7568015 SynGO PMID:7568015 RGD:2317337 NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Syt4 synaptotagmin 4 located_in
is_active_in		 IDA
IEA
ISO		 PMID:30021165
GO_REF:0000044
GO_REF:0000107
(PMID:19136969), (PMID:19448629)		 UniProt
Ensembl
RGD		 PMID:19136969 PMID:19448629 PMID:30021165 GO_REF:0000044 GO_REF:0000107, RGD:14995321 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,038,378...23,046,332 		JBrowse link
G Syt5 synaptotagmin 5 is_active_in ISO
IEA		 (PMID:12006594)
GO_REF:0000107		 RGD
Ensembl		 PMID:12006594 GO_REF:0000107 NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:69,277,351...69,285,067 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21366
    cellular anatomical structure 21071
      endomembrane system 4422
        secretory granule 480
          dense core granule 62
            dense core granule lumen + 9
            dense core granule membrane + 9
            neuronal dense core vesicle + 43
Path 2
Term Annotations click to browse term
  cellular_component 21366
    cellular anatomical structure 21071
      organelle 14293
        membrane-bounded organelle 12863
          vesicle 2268
            intracellular vesicle 2081
              cytoplasmic vesicle 2072
                secretory vesicle 747
                  secretory granule 480
                    dense core granule 62
                      dense core granule lumen + 9
                      dense core granule membrane + 9
                      neuronal dense core vesicle + 43
paths to the root