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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of complement activation
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Accession:GO:0030449 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of complement activation.
Synonyms:exact_synonym: regulation of complement cascade
 xref: Reactome:R-HSA-977606 "Regulation of Complement cascade"


show annotations for term's descendants           Sort by:
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:8195709)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:8195709 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) RGD PMID:25284781 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within NAS
ISO		 (PMID:25284781) RGD PMID:25284781 PMID:7528012 RGD:727654 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cd5l Cd5 molecule-like acts_upstream_of_or_within ISO
IEA		 MGI:2653296 (PMID:25284781)
GO_REF:0000107		 RGD
Ensembl		 PMID:25284781 GO_REF:0000107 NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within IDA
ISO		 MGI:2384179 (PMID:18947875)
(PMID:25284781)		 RGD PMID:18947875 PMID:25284781 PMID:12374811 RGD:628500 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (PMID:25284781)
MGI:2158683 (PMID:18947875)		 RGD PMID:18947875 PMID:25284781 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IEA		 (PMID:23482636)
GO_REF:0000002		 RGD
InterPro		 PMID:23482636 GO_REF:0000002 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59b CD59b molecule acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 (PMID:10946279), (PMID:11471050)
GO_REF:0000033		 RGD
GO_Central		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033, RGD:1600482 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G LOC134480016 urinary protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:43,339,749...43,343,430 JBrowse link
G Rup2l2 urinary protein 2 like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:43,961,640...43,965,241
Ensembl chr 8:35,750,482...35,754,071 		JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in IDA
ISO		 (PMID:28657829), (PMID:6211481) RGD PMID:6211481 PMID:28657829 PMID:10929073 RGD:2326180 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within ISO (PMID:10946279) RGD PMID:10946279 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within IMP
ISO		 MGI:2158683 (PMID:10642554) RGD PMID:10642554 PMID:11861390 RGD:625470 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) RGD PMID:11485744 NCBI chr11:90,839,081...90,909,922
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO
IBA		 UniProtKB:P01024 (PMID:17051150)
GO_REF:0000033		 RGD
GO_Central		 PMID:17051150 GO_REF:0000033 NCBI chr  X:65,154,422...65,179,708
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein, alpha involved_in ISO
IEA
IBA		 (PMID:22333221)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:22333221 GO_REF:0000033 GO_REF:0000107 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in ISO
IEA		 (PMID:22333221)
GO_REF:0000107		 RGD
Ensembl		 PMID:22333221 GO_REF:0000107 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G Cd46 CD46 molecule involved_in ISO
IBA		 (PMID:9029106)
GO_REF:0000033		 RGD
GO_Central		 PMID:9029106 GO_REF:0000033 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd46l1 CD46 molecule like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:34,538,996...34,539,997
Ensembl chr20:33,996,224...33,997,432 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Zp3r zona pellucida 3 receptor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:44,572,283...44,617,101
Ensembl chr13:42,020,018...42,064,812 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:10946292)		 UniProt
Ensembl
RGD		 PMID:10946292 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15611275)		 Ensembl
RGD		 PMID:15611275 GO_REF:0000107 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta involved_in ISO RNAcentral:URS0000424278_9606 (PMID:29384235) RGD PMID:29384235 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mbl2 mannose binding lectin 2 IDA RGD PMID:9920905 RGD:4889148 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30548312) RGD PMID:30548312 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) RGD PMID:20378178 PMID:28671664 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO MGI:2387405 (PMID:9892684) RGD PMID:9892684 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    immune system process 3132
      activation of immune response 599
        complement activation 66
          regulation of complement activation 25
            negative regulation of complement activation + 16
            positive regulation of complement activation + 5
            regulation of activation of membrane attack complex + 4
            regulation of complement activation, alternative pathway + 4
            regulation of complement activation, classical pathway + 10
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20567
    biological regulation 13841
      regulation of biological process 13403
        regulation of response to stimulus 4358
          positive regulation of response to stimulus 2579
            positive regulation of immune response 834
              activation of immune response 599
                complement activation 66
                  regulation of complement activation 25
                    negative regulation of complement activation + 16
                    positive regulation of complement activation + 5
                    regulation of activation of membrane attack complex + 4
                    regulation of complement activation, alternative pathway + 4
                    regulation of complement activation, classical pathway + 10
                    regulation of complement activation, lectin pathway + 2
paths to the root