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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell differentiation
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Accession:GO:0030183 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: B lymphocyte differentiation
 related_synonym: B cell development
 alt_id: GO:0042115


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B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G ADGRG3 adhesion G protein-coupled receptor G3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:37,945,248...37,966,293
Ensembl chr16:57,077,429...57,098,456 		JBrowse link
G AQP8 aquaporin 8 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:25,458,165...25,469,713 JBrowse link
G BCL11A BCL11 transcription factor A acts_upstream_of_or_within ISO (PMID:12717432) MGI PMID:12717432 NCBI chr2A:60,552,908...60,655,437
Ensembl chr2A:61,695,613...61,795,800 		JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G CARD11 caspase recruitment domain family member 11 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:3,166,788...3,304,729
Ensembl chr 7:3,258,736...3,332,999 		JBrowse link
G CD40LG CD40 ligand acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CD79A CD79a molecule involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:38,765,067...38,769,556
Ensembl chr19:47,270,377...47,274,711 		JBrowse link
G CD79B CD79b molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335 		JBrowse link
G CDH17 cadherin 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:90,750,904...90,818,629
Ensembl chr 8:92,696,182...92,760,732 		JBrowse link
G CEBPG CCAAT enhancer binding protein gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:30,295,603...30,304,984
Ensembl chr19:39,046,219...39,046,671 		JBrowse link
G CLCF1 cardiotrophin like cytokine factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:62,722,611...62,734,279 JBrowse link
G CR2 complement C3d receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:183,052,798...183,088,385
Ensembl chr 1:187,330,483...187,366,069 		JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,326,589...51,430,217
Ensembl chr 3:52,560,427...52,663,807 		JBrowse link
G DCLRE1C DNA cross-link repair 1C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:14,901,335...14,956,947
Ensembl chr10:15,236,558...15,269,043 		JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:100,555,527...100,560,052
Ensembl chr 7:113,274,015...113,279,105 		JBrowse link
G EP300 E1A binding protein p300 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726 		JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940 		JBrowse link
G FLT3LG fms related receptor tyrosine kinase 3 ligand involved_in ISO (PMID:38701783) UniProt PMID:38701783 NCBI chr19:46,486,169...46,499,008 JBrowse link
G FNIP1 folliculin interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:28,392,328...28,416,838
Ensembl chr2A:28,485,613...28,498,397 		JBrowse link
G FZD9 frizzled class receptor 9 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr 7:80,588,167...80,590,337 JBrowse link
G GIMAP1 GTPase, IMAP family member 1 acts_upstream_of_or_within ISO (PMID:20194894) MGI PMID:20194894 NCBI chr 7:142,299,040...142,303,621 JBrowse link
G GON4L gon-4 like acts_upstream_of_or_within ISO (PMID:20530203) MGI PMID:20530203 NCBI chr 1:131,084,009...131,193,884
Ensembl chr 1:134,917,791...135,020,042 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in ISO (PMID:28039360) UniProt PMID:28039360 NCBI chr17:7,346,766...7,349,682
Ensembl chr17:7,333,571...7,335,871 		JBrowse link
G HHEX hematopoietically expressed homeobox acts_upstream_of_or_within
involved_in		 ISO (PMID:12522149) MGI
BHF-UCL		 PMID:12522149 NCBI chr10:89,433,402...89,439,137
Ensembl chr10:92,947,373...92,952,992 		JBrowse link
G HMGA1 high mobility group AT-hook 1 acts_upstream_of_or_within ISO (PMID:32341372) MGI PMID:32341372 NCBI chr 6:33,807,171...33,816,603 JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of ISO (PMID:18523151) MGI PMID:18523151 NCBI chr2A:8,681,592...8,684,014
Ensembl chr2A:8,847,776...8,850,720 		JBrowse link
G IKZF1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO (PMID:23071339)
(PMID:7923373)		 MGI PMID:7923373 PMID:23071339 NCBI chr 7:50,946,817...51,047,168
Ensembl chr 7:51,191,685...51,291,245 		JBrowse link
G IKZF3 IKAROS family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:17,459,438...17,498,452
Ensembl chr17:17,643,750...17,741,479 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr  X:60,375,815...60,386,936
Ensembl chr  X:70,433,360...70,437,590 		JBrowse link
G IL9 interleukin 9 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:131,283,170...131,289,777
Ensembl chr 5:137,425,367...137,428,945 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (PMID:9498750) BHF-UCL PMID:9498750 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:69,199,543...69,282,323
Ensembl chr 4:75,761,946...75,844,473 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463 		JBrowse link
G LOC100991889 interleukin-9 receptor acts_upstream_of_or_within ISO (PMID:30082831) MGI PMID:30082831 NCBI chr 9:109,268,011...109,277,418
Ensembl chr  X:155,373,324...155,386,631 		JBrowse link
G LYL1 LYL1 basic helix-loop-helix family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:12,660,548...12,664,513
Ensembl chr19:13,407,596...13,409,309 		JBrowse link
G MS4A1 membrane spanning 4-domains A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:55,691,750...55,706,697
Ensembl chr11:59,134,617...59,149,521 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G MUC19 mucin 19, oligomeric acts_upstream_of_or_within ISO (PMID:37475871) MGI PMID:37475871 NCBI chr12:48,135,613...48,319,443 JBrowse link
G MYB MYB proto-oncogene, transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:132,952,728...132,990,560
Ensembl chr 6:137,048,812...137,086,194 		JBrowse link
G NFAM1 NFAT activating protein with ITAM motif 1 involved_in ISO (PMID:15143214) HGNC-UCL PMID:15143214 NCBI chr22:23,276,675...23,332,932
Ensembl chr22:41,345,206...41,396,721 		JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,326,596...106,419,928
Ensembl chr2B:224,926,183...225,008,788 		JBrowse link
G NKX2-3 NK2 homeobox 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:96,146,636...96,150,238 JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr 1:136,007,476...136,047,355 JBrowse link
G ONECUT1 one cut homeobox 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:31,694,830...31,727,644
Ensembl chr15:50,016,010...50,053,062 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064 		JBrowse link
G POLM DNA polymerase mu acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:44,785,797...44,796,624
Ensembl chr 7:44,852,594...44,862,816 		JBrowse link
G POU1F1 POU class 1 homeobox 1 acts_upstream_of_or_within ISO (PMID:9300691) MGI PMID:9300691 NCBI chr 3:87,390,157...87,407,611
Ensembl chr 3:89,501,298...89,521,168 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:15557316), (PMID:18249142) Ensembl
ARUK-UCL		 PMID:15557316 PMID:18249142 GO_REF:0000107 NCBI chr 1:174,246,389...174,364,893
Ensembl chr 1:178,556,104...178,672,994 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:47,941,134...48,130,538
Ensembl chr11:48,613,761...48,670,494 		JBrowse link
G RABL3 RAB, member of RAS oncogene family like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:117,794,224...117,850,184
Ensembl chr 3:124,707,984...124,748,983 		JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within		 IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr11:36,483,697...36,546,242
Ensembl chr11:36,412,420...36,422,904 		JBrowse link
G RAG2 recombination activating 2 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:1547487), (PMID:1547488) Ensembl
UniProt		 PMID:1547487 PMID:1547488 GO_REF:0000107 NCBI chr11:36,558,419...36,564,997
Ensembl chr11:36,431,703...36,433,286 		JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO (PMID:11967543) MGI PMID:11967543 NCBI chr 4:20,719,548...20,835,439
Ensembl chr 4:25,995,263...26,107,683 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 involved_in ISO (PMID:25613378) UniProt PMID:25613378 NCBI chr  X:108,501,654...108,504,591
Ensembl chr  X:118,926,743...118,929,624 		JBrowse link
G SLC39A7 solute carrier family 39 member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,773,016...32,776,650
Ensembl chr 6:33,887,955...33,891,558 		JBrowse link
G SP3 Sp3 transcription factor acts_upstream_of_or_within ISO (PMID:12676787) MGI PMID:12676787 NCBI chr2B:61,185,975...61,243,155
Ensembl chr2B:178,639,677...178,692,848 		JBrowse link
G SYK spleen associated tyrosine kinase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101 		JBrowse link
G TCIRG1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:63,120,913...63,132,831
Ensembl chr11:66,429,435...66,441,327 		JBrowse link
G TMIGD2 transmembrane and immunoglobulin domain containing 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:3,315,266...3,325,759
Ensembl chr19:4,262,536...4,272,212 		JBrowse link
G TNFSF13B TNF superfamily member 13b involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17581616) Ensembl
MGI		 PMID:17581616 GO_REF:0000107 NCBI chr13:89,399,044...89,438,837
Ensembl chr13:108,536,617...108,574,296 		JBrowse link
G TOP2B DNA topoisomerase II beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:25,499,239...25,566,029
Ensembl chr 3:25,828,879...25,896,912 		JBrowse link
G TPD52 tumor protein D52 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:76,562,979...76,698,329 JBrowse link
G TSHR thyroid stimulating hormone receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:61,517,767...61,708,241
Ensembl chr14:80,718,433...80,905,890 		JBrowse link
G YY1 YY1 transcription factor involved_in ISO (PMID:23531880) MGI PMID:23531880 NCBI chr14:80,859,491...80,903,651 JBrowse link
G ZBTB1 zinc finger and BTB domain containing 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:45,085,146...45,114,965
Ensembl chr14:63,354,458...63,359,403 		JBrowse link
G ZBTB7A zinc finger and BTB domain containing 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,066,554...3,090,285 JBrowse link
B cell affinity maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTK Bruton tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:90,551,874...90,588,786
Ensembl chr  X:100,684,017...100,725,187 		JBrowse link
G TRAF3IP2 TRAF3 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:109,367,333...109,414,601
Ensembl chr 6:113,444,005...113,485,533 		JBrowse link
B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G RAG2 recombination activating 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:36,558,419...36,564,997
Ensembl chr11:36,431,703...36,433,286 		JBrowse link
G TCF3 transcription factor 3 involved_in ISO (PMID:15030778) UniProt PMID:15030778 Ensembl chr19:1,582,297...1,622,025 JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
B cell negative selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 acts_upstream_of_or_within ISO (PMID:16055554) MGI PMID:16055554 NCBI chr 6:33,146,998...33,154,755
Ensembl chr 6:34,255,769...34,263,211 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD19 CD19 molecule involved_in ISO (PMID:7543183) UniProt PMID:7543183 Ensembl chr16:29,320,734...29,327,481 JBrowse link
G MALT1 MALT1 paracaspase acts_upstream_of_or_within ISO (PMID:14614861) MGI PMID:14614861 NCBI chr18:52,060,878...52,141,985
Ensembl chr18:55,395,462...55,473,574 		JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLAMF8 SLAM family member 8 involved_in ISO (PMID:11313408) UniProt PMID:11313408 NCBI chr 1:135,178,241...135,189,005 JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within ISO (PMID:24080084) MGI PMID:24080084 NCBI chr 3:32,308,975...32,372,711 JBrowse link
G DPP4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chr2B:49,285,685...49,368,056
Ensembl chr2B:166,654,659...166,736,588 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (PMID:14595020) MGI PMID:14595020 NCBI chr18:72,948,067...73,083,180
Ensembl chr18:76,017,454...76,094,453 		JBrowse link
G PLCL2 phospholipase C like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:16,736,430...17,015,531
Ensembl chr 3:17,154,500...17,351,287 		JBrowse link
follicular B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF8 interferon regulatory factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073 		JBrowse link
G MUC19 mucin 19, oligomeric acts_upstream_of_or_within ISO (PMID:37475871) MGI PMID:37475871 NCBI chr12:48,135,613...48,319,443 JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:47,301,245...47,326,891
Ensembl chr11:47,853,991...47,880,259 		JBrowse link
germinal center B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868 		JBrowse link
G CDH17 cadherin 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:90,750,904...90,818,629
Ensembl chr 8:92,696,182...92,760,732 		JBrowse link
G IL21 interleukin 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL6 interleukin 6 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRF8 interferon regulatory factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073 		JBrowse link
G ITFG2 integrin alpha FG-GAP repeat containing 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:2,933,227...2,980,509
Ensembl chr12:2,865,297...2,877,555 		JBrowse link
G PHF14 PHD finger protein 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:11,608,934...11,822,039
Ensembl chr 7:10,972,503...11,169,377 		JBrowse link
G POU2AF1 POU class 2 homeobox associating factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:106,231,870...106,258,822
Ensembl chr11:110,078,850...110,103,996 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:47,301,245...47,326,891
Ensembl chr11:47,853,991...47,880,259 		JBrowse link
immature B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FNIP1 folliculin interacting protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218 		JBrowse link
G IRF2BP2 interferon regulatory factor 2 binding protein 2 involved_in ISO (PMID:27016798) UniProt PMID:27016798 NCBI chr 1:210,143,516...210,148,878 JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:69,199,543...69,282,323
Ensembl chr 4:75,761,946...75,844,473 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:47,301,245...47,326,891
Ensembl chr11:47,853,991...47,880,259 		JBrowse link
G SPIB Spi-B transcription factor involved_in ISO (PMID:28062693) ARUK-UCL PMID:28062693 NCBI chr19:47,382,653...47,395,178
Ensembl chr19:56,251,356...56,297,611 		JBrowse link
G SYVN1 synoviolin 1 involved_in ISO (PMID:29907570) UniProt PMID:29907570 NCBI chr11:60,489,626...60,496,945
Ensembl chr11:63,829,138...63,834,364 		JBrowse link
marginal zone B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM10 ADAM metallopeptidase domain 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:37,562,930...37,717,175
Ensembl chr15:55,873,606...56,027,188 		JBrowse link
G BCL3 BCL3 transcription coactivator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:41,696,162...41,708,485
Ensembl chr19:50,304,171...50,313,005 		JBrowse link
G CDH17 cadherin 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:90,750,904...90,818,629
Ensembl chr 8:92,696,182...92,760,732 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:168,440,192...168,449,071
Ensembl chr 6:173,534,292...173,544,759 		JBrowse link
G DOCK10 dedicator of cytokinesis 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:112,006,479...112,283,939
Ensembl chr2B:230,578,452...230,854,877 		JBrowse link
G DOCK11 dedicator of cytokinesis 11 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:107,502,955...107,694,069
Ensembl chr  X:117,952,995...118,161,009 		JBrowse link
G LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISO (PMID:19217325) UniProt PMID:19217325 NCBI chr 7:2,781,493...2,790,936 JBrowse link
G MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:18,385,664...18,407,056
Ensembl chr22:36,218,403...36,239,804 		JBrowse link
G NOTCH2 notch receptor 2 involved_in ISO (PMID:19217325) UniProt PMID:19217325 NCBI chr 1:82,457,829...82,615,142
Ensembl chr 1:117,538,243...117,612,840 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,580,855...26,729,378
Ensembl chr 8:23,869,825...23,932,474 		JBrowse link
G TAOK3 TAO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:115,730,619...115,954,149
Ensembl chr12:119,109,642...119,226,502 		JBrowse link
mature B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL2RG interleukin 2 receptor subunit gamma acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr  X:60,375,815...60,386,936
Ensembl chr  X:70,433,360...70,437,590 		JBrowse link
G POU2F2 POU class 2 homeobox 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:38,974,635...39,065,103
Ensembl chr19:47,570,891...47,611,589 		JBrowse link
mature B cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C19H17orf99 chromosome 19 C17orf99 homolog involved_in ISO (PMID:28978694) UniProt PMID:28978694 NCBI chr17:72,223,073...72,244,049
Ensembl chr17:77,776,151...77,796,139 		JBrowse link
G GPR183 G protein-coupled receptor 183 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:80,461,908...80,475,046
Ensembl chr13:99,601,220...99,602,305 		JBrowse link
G RAG2 recombination activating 2 ISO RGD PMID:30206106 RGD:38508903 NCBI chr11:36,558,419...36,564,997
Ensembl chr11:36,431,703...36,433,286 		JBrowse link
memory B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 involved_in ISO (PMID:10755614) UniProt PMID:10755614 NCBI chr 8:130,111,085...130,227,195
Ensembl chr 8:133,084,835...133,119,791 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:16618805) MGI PMID:16618805 NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940 		JBrowse link
G HMGB3 high mobility group box 3 acts_upstream_of_or_within ISO (PMID:12714519) MGI PMID:12714519 NCBI chr  X:140,632,163...140,639,774 JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:18523151) MGI PMID:18523151 NCBI chr2A:8,681,592...8,684,014
Ensembl chr2A:8,847,776...8,850,720 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:18941195) UniProt PMID:18941195 NCBI chr 8:40,507,027...40,555,053 JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 1:183,094,601...183,246,957 JBrowse link
negative regulation of pre-B cell receptor expression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LAPTM5 lysosomal protein transmembrane 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:30,005,941...30,031,366
Ensembl chr 1:31,032,963...31,058,385 		JBrowse link
plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:29259245) MGI PMID:29259245 NCBI chr 6:129,591,858...129,673,000
Ensembl chr 6:133,698,640...133,783,644 		JBrowse link
G ITM2A integral membrane protein 2A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:68,475,114...68,482,274
Ensembl chr  X:78,585,836...78,593,037 		JBrowse link
G LGALS1 galectin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr22:18,593,154...18,597,432
Ensembl chr22:36,426,228...36,430,356 		JBrowse link
G LGALS8 galectin 8 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:212,083,584...212,112,182 JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,914,957...98,948,467
Ensembl chr 3:105,616,645...105,628,300 		JBrowse link
G NKX2-3 NK2 homeobox 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:96,146,636...96,150,238 JBrowse link
positive regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP11C ATPase phospholipid transporting 11C involved_in ISO (PMID:21423173) UniProt PMID:21423173 NCBI chr  X:128,880,747...129,085,989
Ensembl chr  X:139,132,783...139,334,869 		JBrowse link
G BAD BCL2 associated agonist of cell death acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257 		JBrowse link
G CD27 CD27 molecule involved_in IEA InterPro GO_REF:0000002 NCBI chr12:6,575,104...6,582,127
Ensembl chr12:6,492,119...6,499,427 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:60,375,815...60,386,936
Ensembl chr  X:70,433,360...70,437,590 		JBrowse link
G IL7 interleukin 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:75,254,166...75,337,373
Ensembl chr 8:76,895,095...76,966,918 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOC100989105 signal transducer and activator of transcription 5B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463 		JBrowse link
G MMP14 matrix metallopeptidase 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:34,200,102...34,249,873
Ensembl chr12:34,932,470...34,977,881 		JBrowse link
G PCID2 PCI domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:94,319,699...94,350,763
Ensembl chr13:113,388,251...113,419,251 		JBrowse link
G PPP2R3C protein phosphatase 2 regulatory subunit B''gamma involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:15,834,603...15,871,741
Ensembl chr14:34,020,893...34,056,842 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:47,301,245...47,326,891
Ensembl chr11:47,853,991...47,880,259 		JBrowse link
G SYK spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in		 IEA Ensembl GO_REF:0000107 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:9,863,479...9,869,491
Ensembl chr22:27,567,041...27,571,943 		JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDRGK1 DDRGK domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:3,276,292...3,290,433
Ensembl chr20:3,038,779...3,052,789 		JBrowse link
G IL10 interleukin 10 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL2 interleukin 2 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:9,863,479...9,869,491
Ensembl chr22:27,567,041...27,571,943 		JBrowse link
pre-B cell allelic exclusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G RAG1 recombination activating 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:36,483,697...36,546,242
Ensembl chr11:36,412,420...36,422,904 		JBrowse link
G RAG2 recombination activating 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:36,558,419...36,564,997
Ensembl chr11:36,431,703...36,433,286 		JBrowse link
pre-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP11C ATPase phospholipid transporting 11C involved_in ISO (PMID:21423173) UniProt PMID:21423173 NCBI chr  X:128,880,747...129,085,989
Ensembl chr  X:139,132,783...139,334,869 		JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chr 3:70,893,933...71,523,892
Ensembl chr 3:72,258,456...72,498,173 		JBrowse link
G LOC100982539 signal transducer CD24 acts_upstream_of_or_within ISO (PMID:7795661), (PMID:9028339) MGI PMID:7795661 PMID:9028339 NCBI chr 6:104,783,720...104,789,509
Ensembl chr 6:108,655,624...108,657,847 		JBrowse link
G LRRC8A leucine rich repeat containing 8 VRAC subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:100,003,969...100,039,859
Ensembl chr 9:128,670,292...128,705,466 		JBrowse link
regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKLE1 ankyrin repeat and LEM domain containing 1 NOT|involved_in ISO (PMID:27010503) UniProt PMID:27010503 NCBI chr19:16,769,670...16,775,114
Ensembl chr19:17,744,570...17,750,070 		JBrowse link
G CARD11 caspase recruitment domain family member 11 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:3,166,788...3,304,729
Ensembl chr 7:3,258,736...3,332,999 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G FAS Fas cell surface death receptor acts_upstream_of_or_within ISO (PMID:6610701) MGI PMID:6610701 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FCRL3 Fc receptor like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:133,038,100...133,062,467
Ensembl chr 1:136,830,553...136,855,027 		JBrowse link
G IKZF3 IKAROS family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:17,459,438...17,498,452
Ensembl chr17:17,643,750...17,741,479 		JBrowse link
G LOC100982539 signal transducer CD24 acts_upstream_of_or_within ISO (PMID:7795661), (PMID:9028339) MGI PMID:7795661 PMID:9028339 NCBI chr 6:104,783,720...104,789,509
Ensembl chr 6:108,655,624...108,657,847 		JBrowse link
G LOC100986336 twinfilin-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,163,388...52,181,473
Ensembl chr 3:53,400,191...53,410,743
Ensembl chr 3:53,400,191...53,410,743 		JBrowse link
G NFAM1 NFAT activating protein with ITAM motif 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15143214) InterPro
MGI		 PMID:15143214 GO_REF:0000002 NCBI chr22:23,276,675...23,332,932
Ensembl chr22:41,345,206...41,396,721 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:7,075,879...7,093,041
Ensembl chr12:6,991,099...7,008,830 		JBrowse link
G SLAMF8 SLAM family member 8 involved_in ISO (PMID:11313408) UniProt PMID:11313408 NCBI chr 1:135,178,241...135,189,005 JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:49,372,058...49,379,116
Ensembl chr14:68,247,347...68,255,805 		JBrowse link
G ZFP36L2 ZFP36 ring finger protein like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:43,311,744...43,315,928 JBrowse link
transitional one stage B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941 		JBrowse link
G TNFSF13B TNF superfamily member 13b acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:89,399,044...89,438,837
Ensembl chr13:108,536,617...108,574,296 		JBrowse link
transitional two stage B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRAF3IP2 TRAF3 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:109,367,333...109,414,601
Ensembl chr 6:113,444,005...113,485,533 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2521
      leukocyte activation 1005
        lymphocyte activation 816
          lymphocyte differentiation 434
            B cell differentiation 147
              B cell lineage commitment + 6
              B cell selection + 4
              immature B cell differentiation + 18
              mature B cell differentiation + 46
              negative regulation of B cell differentiation + 6
              positive regulation of B cell differentiation + 18
              regulation of B cell differentiation + 37
Path 2
Term Annotations click to browse term
  biological_process 19315
    developmental process 6686
      cellular developmental process 4499
        cell differentiation 4498
          cell development 3201
            hemopoiesis 1031
              leukocyte differentiation 665
                mononuclear cell differentiation 537
                  lymphocyte differentiation 434
                    B cell differentiation 147
                      B cell lineage commitment + 6
                      B cell selection + 4
                      immature B cell differentiation + 18
                      mature B cell differentiation + 46
                      negative regulation of B cell differentiation + 6
                      positive regulation of B cell differentiation + 18
                      regulation of B cell differentiation + 37
paths to the root