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ONTOLOGY REPORT - ANNOTATIONS

Term:L-malate dehydrogenase (NAD+) activity
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Accession:GO:0030060 term browser browse the term
Definition:Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
Synonyms:related_synonym: (S)-malate:NAD+ oxidoreductase activity;   L-malate-NAD+ oxidoreductase activity;   MDH;   NAD-dependent malate dehydrogenase activity;   NAD-dependent malic dehydrogenase activity;   NAD-linked malate dehydrogenase activity;   NAD-malate dehydrogenase activity;   NAD-malic dehydrogenase activity;   NAD-specific malate dehydrogenase activity;   malic acid dehydrogenase activity;   malic dehydrogenase activity
 xref: EC:1.1.1.37;   MetaCyc:MALATE-DEH-RXN;   RHEA:21432;   Reactome:R-HSA-70979 "MDH2 dimer dehydrogenates MAL";   Reactome:R-HSA-9856871 "MDH1 reduces OA"


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L-malate dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mdh1 malate dehydrogenase 1 enables IDA
IEA
ISO
IBA		 GO_REF:0000003
GO_REF:0000116
GO_REF:0000107
GO_REF:0000002
MGI:1933639 (PMID:5770240), (PMID:7698769)
GO_REF:0000033
GO_REF:0000117
(PMID:3052244)		 UniProt
RHEA
Ensembl
InterPro
RGD
GO_Central		 PMID:3052244 PMID:5770240 PMID:7698769 PMID:17447164 PMID:12351438 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:1624966, RGD:2303499 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mdh1b malate dehydrogenase 1B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:72,614,185...72,661,820
Ensembl chr 9:65,119,029...65,167,933 		JBrowse link
G Mdh2 malate dehydrogenase 2 enables IDA
IEA
ISO
IBA		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000116
GO_REF:0000003
(PMID:1203052), (PMID:5496232)
GO_REF:0000033
(PMID:16740313), (PMID:27989324), (PMID:6576816)
GO_REF:0000117		 Ensembl
InterPro
RHEA
UniProt
RGD
GO_Central		 PMID:1203052 PMID:5496232 PMID:6576816 PMID:16740313 PMID:27989324 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:2303499 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      oxidoreductase activity 868
        oxidoreductase activity, acting on CH-OH group of donors 165
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 156
            L-malate dehydrogenase (NAD+) activity 3
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