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ONTOLOGY REPORT - ANNOTATIONS

Term:desmosome
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Accession:GO:0030057 term browser browse the term
Definition:A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
Synonyms:exact_synonym: macula adherens;   spot desmosome
 xref: Wikipedia:Desmosome


show annotations for term's descendants           Sort by:
desmosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt1 beta-1,4-galactosyltransferase 1 located_in ISO
IEA 		(PMID:3917437)
GO_REF:0000107 		RGD
Ensembl		 PMID:3917437 GO_REF:0000107 NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:60,731,602...60,778,445 		JBrowse link
G Cdh1 cadherin 1 located_in IEA
ISO 		GO_REF:0000044
(PMID:29999492)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:29999492 GO_REF:0000044 GO_REF:0000107 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 located_in ISS
IDA
IEA
ISO 		GO_REF:0000024
PMID:21617128
GO_REF:0000044
GO_REF:0000107
GO_REF:0000117
(PMID:15479741) 		UniProt
Ensembl
RGD		 PMID:15479741 PMID:21617128 GO_REF:0000024 GO_REF:0000044 GO_REF:0000107 GO_REF:0000117, RGD:6767286 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdsn corneodesmosin located_in ISO
IEA 		(PMID:11279026), (PMID:26014679)
GO_REF:0000107 		RGD
Ensembl		 PMID:11279026 PMID:26014679 GO_REF:0000107 NCBI chr20:3,184,142...3,188,962
Ensembl chr20:3,183,808...3,188,962 		JBrowse link
G Dsc1 desmocollin 1 is_active_in
located_in 		IBA
ISO
IEA 		GO_REF:0000033
(PMID:14673151), (PMID:38395410)
GO_REF:0000117
GO_REF:0000044
GO_REF:0000107 		GO_Central
RGD
UniProt
Ensembl		 PMID:14673151 PMID:38395410 GO_REF:0000033 GO_REF:0000044 GO_REF:0000107 GO_REF:0000117 NCBI chr18:11,774,711...11,831,868
Ensembl chr18:11,775,010...11,803,522 		JBrowse link
G Dsc2 desmocollin 2 is_active_in
located_in 		IBA
ISO
IEA 		GO_REF:0000033
(PMID:15775979), (PMID:38395410), (PMID:9864371)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000044
(PMID:17963498), (PMID:21062920), (PMID:21220045) 		GO_Central
RGD
UniProt
Ensembl		 PMID:9864371 PMID:15775979 PMID:17963498 PMID:21062920 PMID:21220045 More... GO_REF:0000033 GO_REF:0000044 GO_REF:0000107 GO_REF:0000117 NCBI chr18:11,725,466...11,757,591
Ensembl chr18:11,725,466...11,757,466 		JBrowse link
G Dsc3 desmocollin 3 is_active_in
located_in 		IBA
ISO
IEA 		GO_REF:0000033
(PMID:14673151), (PMID:38395410)
GO_REF:0000117
GO_REF:0000044
GO_REF:0000107 		GO_Central
RGD
UniProt
Ensembl		 PMID:14673151 PMID:38395410 GO_REF:0000033 GO_REF:0000044 GO_REF:0000107 GO_REF:0000117 NCBI chr18:11,654,833...11,688,871
Ensembl chr18:11,653,832...11,688,871 		JBrowse link
G Dsg1 desmoglein 1 located_in
is_active_in 		ISO
IEA
IBA 		(PMID:34368962)
(PMID:12631242), (PMID:14673151), (PMID:15775979)
GO_REF:0000107
GO_REF:0000117
GO_REF:0000044
GO_REF:0000033 		RGD
Ensembl
UniProt
GO_Central		 PMID:12631242 PMID:14673151 PMID:15775979 PMID:34368962 GO_REF:0000033 GO_REF:0000044 GO_REF:0000107 GO_REF:0000117 NCBI chr18:11,948,098...11,980,455
Ensembl chr18:11,949,488...11,980,451 		JBrowse link
G Dsg2 desmoglein 2 is_active_in
located_in 		IBA
ISO
IEA 		GO_REF:0000033
(PMID:12494996), (PMID:12631242), (PMID:14673151), (PMID:15775979), (PMID:22274697), (PMID:38395410), (PMID:9864371)
GO_REF:0000107
GO_REF:0000044
(PMID:20859650), (PMID:23381804), (PMID:29999492) 		GO_Central
RGD
Ensembl
UniProt		 PMID:9864371 PMID:12494996 PMID:12631242 PMID:14673151 PMID:15775979 More... GO_REF:0000033 GO_REF:0000044 GO_REF:0000107 NCBI chr18:12,121,287...12,179,590
Ensembl chr18:12,121,181...12,179,590 		JBrowse link
G Dsg3 desmoglein 3 is_active_in
located_in 		IBA
IEA 		GO_REF:0000033
GO_REF:0000044 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000044 NCBI chr18:12,074,321...12,105,954
Ensembl chr18:12,074,321...12,111,766 		JBrowse link
G Dsg4 desmoglein 4 is_active_in
located_in 		IBA
ISO
IEA 		GO_REF:0000033
MGI:1856929 (PMID:12705872)
GO_REF:0000044
GO_REF:0000107 		GO_Central
RGD
UniProt
Ensembl		 PMID:12705872 GO_REF:0000033 GO_REF:0000044 GO_REF:0000107 NCBI chr18:11,995,902...12,032,908
Ensembl chr18:11,995,902...12,032,908 		JBrowse link
G Dsp desmoplakin located_in IDA
ISO
IEA 		(PMID:12494996), (PMID:14673151), (PMID:15479741), (PMID:16418220), (PMID:18079750), (PMID:18496566), (PMID:22515648), (PMID:25617501), (PMID:27033150), (PMID:27375112), (PMID:28507225), (PMID:38395410)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000044
(PMID:18343367), (PMID:20859650) 		RGD
UniProt
Ensembl		 PMID:12494996 PMID:14673151 PMID:15479741 PMID:16418220 PMID:18079750 More... GO_REF:0000044 GO_REF:0000107 GO_REF:0000117, RGD:1581654 NCBI chr17:26,829,153...26,877,419
Ensembl chr17:26,829,153...26,877,121 		JBrowse link
G Evpl envoplakin located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr10:101,957,107...101,973,656
Ensembl chr10:101,941,064...101,973,656 		JBrowse link
G Jam3 junctional adhesion molecule 3 located_in ISO
IEA 		(PMID:15194813)
GO_REF:0000044
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:15194813 GO_REF:0000044 GO_REF:0000107 NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623 		JBrowse link
G Jup junction plakoglobin located_in IDA
ISO
IEA 		(PMID:10662781)
MGI:1857539 (PMID:14673151), (PMID:15775979), (PMID:18496566), (PMID:21880664), (PMID:22515648), (PMID:38395410), (PMID:9864371)
GO_REF:0000044
GO_REF:0000107
(PMID:1639850), (PMID:20859650), (PMID:2726765)
PMID:21617128
PMID:26858265 		RGD
UniProt
Ensembl		 PMID:1639850 PMID:2726765 PMID:9864371 PMID:10662781 PMID:14673151 More... GO_REF:0000044 GO_REF:0000107, RGD:1581654, RGD:6767286, RGD:11526329 NCBI chr10:85,800,812...85,827,881
Ensembl chr10:85,800,814...85,827,429 		JBrowse link
G Kazn kazrin, periplakin interacting protein located_in ISO
IEA 		(PMID:15337775)
GO_REF:0000107 		RGD
Ensembl		 PMID:15337775 GO_REF:0000107 NCBI chr 5:159,675,803...160,666,084
Ensembl chr 5:159,675,803...160,664,154 		JBrowse link
G Klhl24 kelch-like family member 24 located_in ISO
IEA
ISS 		(PMID:27889062)
GO_REF:0000044
GO_REF:0000107
GO_REF:0000024 		RGD
UniProt
Ensembl		 PMID:27889062 GO_REF:0000024 GO_REF:0000044 GO_REF:0000107 NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050 		JBrowse link
G Krt80 keratin 80 NOT|located_in ISO (PMID:20843789) RGD PMID:20843789 NCBI chr 7:134,341,951...134,363,872
Ensembl chr 7:134,341,956...134,364,211 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 located_in IEA
ISO 		GO_REF:0000107
(PMID:22515648)
GO_REF:0000044 		Ensembl
RGD
UniProt		 PMID:22515648 GO_REF:0000044 GO_REF:0000107 NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:15,361,778...15,374,687 		JBrowse link
G Pkp1 plakophilin 1 located_in ISO
IEA 		(PMID:20613778), (PMID:23444369)
(PMID:18496566), (PMID:27033150), (PMID:27375112), (PMID:29678907)
GO_REF:0000044
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:18496566 PMID:20613778 PMID:23444369 PMID:27033150 PMID:27375112 More... GO_REF:0000044 GO_REF:0000107 GO_REF:0000117 NCBI chr13:49,861,340...49,909,162
Ensembl chr13:49,861,340...49,909,162 		JBrowse link
G Pkp2 plakophilin 2 located_in IDA
ISO
IEA 		PMID:21617128
(PMID:22274697), (PMID:38395410), (PMID:9864371)
GO_REF:0000117
GO_REF:0000044
GO_REF:0000107
(PMID:20613778), (PMID:20859650), (PMID:34368962) 		RGD
UniProt
Ensembl		 PMID:9864371 PMID:20613778 PMID:20859650 PMID:22274697 PMID:34368962 More... GO_REF:0000044 GO_REF:0000107 GO_REF:0000117, RGD:6767286 NCBI chr11:98,165,974...98,231,916
Ensembl chr11:98,165,974...98,231,916 		JBrowse link
G Pkp3 plakophilin 3 located_in ISO
IEA 		(PMID:20613778), (PMID:20859650), (PMID:24124604), (PMID:25501895)
(PMID:14673151), (PMID:18079750), (PMID:27033150), (PMID:27375112), (PMID:29678907), (PMID:38395410)
GO_REF:0000044
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:14673151 PMID:18079750 PMID:20613778 PMID:20859650 PMID:24124604 More... GO_REF:0000044 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:205,617,511...205,628,441
Ensembl chr 1:205,617,511...205,628,440 		JBrowse link
G Pkp4 plakophilin 4 located_in ISO
IEA 		(PMID:8937994)
GO_REF:0000107 		RGD
Ensembl		 PMID:8937994 GO_REF:0000107 NCBI chr 3:64,040,995...64,244,586
Ensembl chr 3:64,141,771...64,244,586 		JBrowse link
G Pnn pinin, desmosome associated protein located_in IEA
ISO 		GO_REF:0000044
(PMID:8922384) 		UniProt
RGD		 PMID:8922384 GO_REF:0000044 NCBI chr 6:82,493,032...82,501,345
Ensembl chr 6:82,492,978...82,501,933 		JBrowse link
G Pof1b POF1B, actin binding protein located_in ISO
IEA 		(PMID:17123869)
GO_REF:0000107 		RGD
Ensembl		 PMID:17123869 GO_REF:0000107 NCBI chr  X:81,875,348...81,942,046
Ensembl chr  X:81,875,348...81,941,906 		JBrowse link
G Ppl periplakin located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr10:10,957,388...11,003,035
Ensembl chr10:10,957,341...11,003,658 		JBrowse link
G Tchp trichoplein, keratin filament binding located_in IEA
ISO 		GO_REF:0000107
(PMID:21325031) 		Ensembl
RGD		 PMID:21325031 GO_REF:0000107 NCBI chr12:47,538,520...47,553,895
Ensembl chr12:47,538,520...47,553,836 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 located_in IEA
ISO 		GO_REF:0000107
(PMID:1376922) 		Ensembl
RGD		 PMID:1376922 GO_REF:0000107 NCBI chr  X:4,062,216...4,084,192
Ensembl chr  X:4,062,182...4,084,246 		JBrowse link
inner dense plaque of desmosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin, alpha 1 located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172 		JBrowse link
G Vcl vinculin located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163 		JBrowse link
outer dense plaque of desmosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin, alpha 1 located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172 		JBrowse link
G Vcl vinculin located_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19485
    cellular anatomical structure 19353
      cell junction 2620
        anchoring junction 754
          cell-cell junction 562
            desmosome 30
              extracellular core region of desmosome 0
              inner dense plaque of desmosome 2
              outer dense plaque of desmosome 2
paths to the root