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ONTOLOGY REPORT - ANNOTATIONS

Term:muscle filament sliding
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Accession:GO:0030049 term browser browse the term
Definition:The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
Synonyms:xref: Reactome:R-HSA-390522 "Striated Muscle Contraction"

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muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myh8 myosin heavy chain 8 involved_in ISO (PMID:17041932) BHF-UCL PMID:17041932 NCBI chrNW_004624786:12,756,731...12,786,312
Ensembl chrNW_004624786:12,756,852...12,785,997 		JBrowse link
G Tnnt2 troponin T2, cardiac type involved_in ISO (PMID:12186860), (PMID:15923195) UniProt PMID:12186860 PMID:15923195 NCBI chrNW_004624807:9,332,202...9,348,610
Ensembl chrNW_004624807:9,336,904...9,348,396 		JBrowse link
G Tpm1 tropomyosin 1 involved_in ISO PMID:11136687 BHF-UCL PMID:11136687 RGD:1556479 NCBI chrNW_004624781:9,414,500...9,442,357
Ensembl chrNW_004624781:9,414,500...9,442,544 		JBrowse link
negative regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbn1 drebrin 1 ISO RGD PMID:17543276 RGD:10398727 NCBI chrNW_004624733:12,616,537...12,631,967
Ensembl chrNW_004624733:12,616,423...12,632,133 		JBrowse link
regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mylk2 myosin light chain kinase 2 involved_in ISO (PMID:16448786) BHF-UCL PMID:16448786 NCBI chrNW_004624741:680,230...693,895
Ensembl chrNW_004624741:680,016...693,908 		JBrowse link
regulation of muscle filament sliding speed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnnc1 troponin C1, slow skeletal and cardiac type involved_in ISO (PMID:10747195) BHF-UCL PMID:10747195 NCBI chrNW_004624822:4,763,285...4,767,810
Ensembl chrNW_004624822:4,764,742...4,770,293 		JBrowse link
G Tnnt2 troponin T2, cardiac type involved_in ISO PMID:10747195 BHF-UCL PMID:10747195 RGD:8554013 NCBI chrNW_004624807:9,332,202...9,348,610
Ensembl chrNW_004624807:9,336,904...9,348,396 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17650
    multicellular organismal process 7715
      system process 2857
        muscle system process 446
          muscle contraction 315
            muscle filament sliding 6
              negative regulation of muscle filament sliding 1
              positive regulation of muscle filament sliding 0
              regulation of muscle filament sliding + 4
Path 2
Term Annotations click to browse term
  biological_process 17650
    cellular process 17226
      actin filament-based process 772
        actin filament-based movement 115
          actin-mediated cell contraction 93
            actin-myosin filament sliding 7
              muscle filament sliding 6
                negative regulation of muscle filament sliding 1
                positive regulation of muscle filament sliding 0
                regulation of muscle filament sliding + 4
paths to the root