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ONTOLOGY REPORT - ANNOTATIONS

Term:muscle filament sliding
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Accession:GO:0030049 term browser browse the term
Definition:The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
Synonyms:xref: Reactome:R-HSA-390522 "Striated Muscle Contraction"


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muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta involved_in IEA
IBA
ISO		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083 		JBrowse link
G Myh8 myosin, heavy polypeptide 8, skeletal muscle, perinatal involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr11:67,167,950...67,199,460
Ensembl chr11:67,167,950...67,199,460 		JBrowse link
G Myl6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle involved_in TAS (PMID:2304459) HGNC-UCL PMID:2304459 NCBI chr10:128,326,728...128,329,755
Ensembl chr10:128,326,729...128,330,014 		JBrowse link
G Myl6b myosin, light polypeptide 6B involved_in TAS (PMID:2304459) HGNC-UCL PMID:2304459 NCBI chr10:128,330,026...128,334,554
Ensembl chr10:128,330,026...128,334,554 		JBrowse link
G Tnnc1 troponin C, cardiac/slow skeletal involved_in NAS (PMID:31954841) ComplexPortal PMID:31954841 NCBI chr14:30,930,274...30,933,671
Ensembl chr14:30,930,269...30,933,686 		JBrowse link
G Tnni3 troponin I, cardiac 3 involved_in NAS (PMID:31954841) ComplexPortal PMID:31954841 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Tnnt2 troponin T2, cardiac involved_in ISO
NAS
ISS		 (PMID:31954841) GO_Central
ComplexPortal
UniProt		 PMID:31954841 GO_REF:0000024 GO_REF:0000119 NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998 		JBrowse link
G Tpm1 tropomyosin 1, alpha involved_in ISO GO_Central GO_REF:0000096 NCBI chr 9:66,929,872...66,956,954
Ensembl chr 9:66,929,872...66,956,688 		JBrowse link
negative regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbn1 drebrin 1 involved_in ISO RGD
GO_Central		 PMID:17543276 GO_REF:0000096 RGD:10398727 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924 		JBrowse link
regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mylk2 myosin, light polypeptide kinase 2, skeletal muscle involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:152,753,265...152,764,985
Ensembl chr 2:152,753,272...152,764,988 		JBrowse link
regulation of muscle filament sliding speed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnnc1 troponin C, cardiac/slow skeletal involved_in IMP (PMID:10747195) BHF-UCL PMID:10747195 NCBI chr14:30,930,274...30,933,671
Ensembl chr14:30,930,269...30,933,686 		JBrowse link
G Tnnt2 troponin T2, cardiac involved_in ISO GO_Central GO_REF:0000096 NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28628
    multicellular organismal process 9102
      system process 3340
        muscle system process 495
          muscle contraction 347
            muscle filament sliding 11
              negative regulation of muscle filament sliding 1
              positive regulation of muscle filament sliding 0
              regulation of muscle filament sliding + 4
Path 2
Term Annotations click to browse term
  biological_process 28628
    cellular process 18389
      actin filament-based process 847
        actin filament-based movement 131
          actin-mediated cell contraction 107
            actin-myosin filament sliding 13
              muscle filament sliding 11
                negative regulation of muscle filament sliding 1
                positive regulation of muscle filament sliding 0
                regulation of muscle filament sliding + 4
paths to the root