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ONTOLOGY REPORT - ANNOTATIONS

Term:muscle filament sliding
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Accession:GO:0030049 term browser browse the term
Definition:The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
Synonyms:xref: Reactome:R-HSA-390522 "Striated Muscle Contraction"


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muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYH2 myosin heavy chain 2 involved_in NAS (PMID:3904738) BHF-UCL PMID:3904738 NCBI chr17:10,521,148...10,549,658
Ensembl chr17:10,521,148...10,549,700 		JBrowse link
G MYH3 myosin heavy chain 3 involved_in TAS Reactome Reactome:R-HSA-390522 NCBI chr17:10,628,532...10,678,417
Ensembl chr17:10,628,526...10,657,309 		JBrowse link
G MYH4 myosin heavy chain 4 involved_in NAS (PMID:3904738) BHF-UCL PMID:3904738 NCBI chr17:10,443,263...10,469,559
Ensembl chr17:10,443,290...10,469,559 		JBrowse link
G MYH6 myosin heavy chain 6 involved_in IMP
TAS		 (PMID:16088376) HGNC-UCL
Reactome		 PMID:16088376 Reactome:R-HSA-390522 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273 		JBrowse link
G MYH7 myosin heavy chain 7 involved_in IMP
IBA		 (PMID:16088376), (PMID:8514894) HGNC-UCL
GO_Central		 PMID:8514894 PMID:16088376 GO_REF:0000033 NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660 		JBrowse link
G MYH8 myosin heavy chain 8 involved_in IMP
TAS		 (PMID:17041932) BHF-UCL
Reactome		 PMID:17041932 Reactome:R-HSA-390522 NCBI chr17:10,390,322...10,421,950
Ensembl chr17:10,390,322...10,421,950 		JBrowse link
G MYL1 myosin light chain 1 involved_in NAS (PMID:3904738) BHF-UCL PMID:3904738 NCBI chr 2:210,290,150...210,315,174
Ensembl chr 2:210,290,150...210,315,174 		JBrowse link
G MYL6 myosin light chain 6 involved_in TAS (PMID:2304459) HGNC-UCL PMID:2304459 NCBI chr12:56,158,359...56,161,579
Ensembl chr12:56,158,346...56,163,496 		JBrowse link
G MYL6B myosin light chain 6B involved_in TAS (PMID:2304459) HGNC-UCL PMID:2304459 NCBI chr12:56,152,587...56,157,982
Ensembl chr12:56,152,256...56,159,647 		JBrowse link
G TCAP titin-cap involved_in NAS (PMID:16407954) ComplexPortal PMID:16407954 NCBI chr17:39,665,349...39,666,554
Ensembl chr17:39,665,349...39,666,554 		JBrowse link
G TNNC1 troponin C1, slow skeletal and cardiac type involved_in NAS (PMID:12840750) ComplexPortal PMID:12840750 NCBI chr 3:52,451,100...52,454,041
Ensembl chr 3:52,451,100...52,454,041 		JBrowse link
G TNNI3 troponin I3, cardiac type involved_in NAS (PMID:12840750) ComplexPortal PMID:12840750 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773 		JBrowse link
G TNNT2 troponin T2, cardiac type involved_in IDA
NAS		 (PMID:12186860), (PMID:15923195)
(PMID:12840750)		 UniProt
ComplexPortal		 PMID:12186860 PMID:12840750 PMID:15923195 NCBI chr 1:201,359,014...201,377,680
Ensembl chr 1:201,359,008...201,377,764 		JBrowse link
G TPM1 tropomyosin 1 involved_in ISS (PMID:11136687) BHF-UCL PMID:11136687 NCBI chr15:63,042,747...63,071,915
Ensembl chr15:63,042,620...63,071,915 		JBrowse link
G TTN titin involved_in NAS (PMID:16407954) ComplexPortal PMID:16407954 NCBI chr 2:178,525,989...178,807,423
Ensembl chr 2:178,525,989...178,830,802 		JBrowse link
negative regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBN1 drebrin 1 ISO RGD PMID:17543276 RGD:10398727 NCBI chr 5:177,456,610...177,473,634
Ensembl chr 5:177,456,608...177,474,401 		JBrowse link
regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYBPC3 myosin binding protein C3 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr11:47,331,406...47,352,702
Ensembl chr11:47,331,406...47,352,702 		JBrowse link
G MYLK2 myosin light chain kinase 2 involved_in IDA (PMID:16448786) BHF-UCL PMID:16448786 NCBI chr20:31,819,356...31,834,684
Ensembl chr20:31,819,308...31,834,689 		JBrowse link
regulation of muscle filament sliding speed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNNC1 troponin C1, slow skeletal and cardiac type involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:52,451,100...52,454,041
Ensembl chr 3:52,451,100...52,454,041 		JBrowse link
G TNNT2 troponin T2, cardiac type involved_in ISO PMID:10747195 BHF-UCL PMID:10747195 RGD:8554013 NCBI chr 1:201,359,014...201,377,680
Ensembl chr 1:201,359,008...201,377,764 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27213
    multicellular organismal process 8840
      system process 2953
        muscle system process 569
          muscle contraction 405
            muscle filament sliding 18
              negative regulation of muscle filament sliding 1
              positive regulation of muscle filament sliding 0
              regulation of muscle filament sliding + 5
Path 2
Term Annotations click to browse term
  biological_process 27213
    cellular process 19795
      actin filament-based process 910
        actin filament-based movement 155
          actin-mediated cell contraction 132
            actin-myosin filament sliding 20
              muscle filament sliding 18
                negative regulation of muscle filament sliding 1
                positive regulation of muscle filament sliding 0
                regulation of muscle filament sliding + 5
paths to the root