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ONTOLOGY REPORT - ANNOTATIONS

Term:muscle filament sliding
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Accession:GO:0030049 term browser browse the term
Definition:The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
Synonyms:xref: Reactome:R-HSA-390522 "Striated Muscle Contraction"


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muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYH13 myosin heavy chain 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:34,617,987...34,669,349
Ensembl chr 5:34,617,971...34,669,589 		JBrowse link
G MYH6 myosin heavy chain 6 involved_in IEA Ensembl GO_REF:0000107
G MYH7 myosin heavy chain 7 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:3,660,155...3,677,650
Ensembl chr 8:3,629,585...3,792,725 		JBrowse link
G MYH8 myosin heavy chain 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:34,696,377...34,725,515
Ensembl chr 5:34,696,371...34,723,574 		JBrowse link
G TNNT2 troponin T2, cardiac type involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741 		JBrowse link
G TPM1 tropomyosin 1 involved_in ISO PMID:11136687 BHF-UCL PMID:11136687 RGD:1556479 NCBI chr30:27,636,407...27,664,907
Ensembl chr30:27,636,283...27,664,442 		JBrowse link
negative regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBN1 drebrin 1 ISO RGD PMID:17543276 RGD:10398727 NCBI chr 4:35,899,969...35,913,015
Ensembl chr 4:35,889,392...35,912,507 		JBrowse link
regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYLK2 myosin light chain kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:21,284,309...21,297,889
Ensembl chr24:21,284,352...21,309,363 		JBrowse link
regulation of muscle filament sliding speed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNNC1 troponin C1, slow skeletal and cardiac type involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,313,983...37,317,288
Ensembl chr20:37,311,966...37,317,321 		JBrowse link
G TNNT2 troponin T2, cardiac type involved_in ISO PMID:10747195 BHF-UCL PMID:10747195 RGD:8554013 NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    multicellular organismal process 8214
      system process 2938
        muscle system process 482
          muscle contraction 341
            muscle filament sliding 9
              negative regulation of muscle filament sliding 1
              positive regulation of muscle filament sliding 0
              regulation of muscle filament sliding + 4
Path 2
Term Annotations click to browse term
  biological_process 22141
    cellular process 21672
      actin filament-based process 845
        actin filament-based movement 129
          actin-mediated cell contraction 104
            actin-myosin filament sliding 10
              muscle filament sliding 9
                negative regulation of muscle filament sliding 1
                positive regulation of muscle filament sliding 0
                regulation of muscle filament sliding + 4
paths to the root