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ONTOLOGY REPORT - ANNOTATIONS

Term:muscle filament sliding
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Accession:GO:0030049 term browser browse the term
Definition:The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
Synonyms:xref: Reactome:R-HSA-390522 "Striated Muscle Contraction"


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muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100978529 myosin-7 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763 		JBrowse link
G LOC103782669 myosin-8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,231,081...41,262,671
Ensembl chr17:45,978,472...46,010,038 		JBrowse link
G MYH6 myosin heavy chain 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331 		JBrowse link
G TNNT2 troponin T2, cardiac type involved_in ISO (PMID:12186860), (PMID:15923195) UniProt PMID:12186860 PMID:15923195 NCBI chr 1:176,957,298...176,976,033 JBrowse link
G TPM1 tropomyosin 1 involved_in ISO PMID:11136687 BHF-UCL PMID:11136687 RGD:1556479 NCBI chr15:41,989,239...42,018,520
Ensembl chr15:60,286,587...60,315,530 		JBrowse link
negative regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBN1 drebrin 1 ISO RGD PMID:17543276 RGD:10398727 NCBI chr 5:172,758,316...172,774,974
Ensembl chr 5:179,820,791...179,836,872 		JBrowse link
regulation of muscle filament sliding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYLK2 myosin light chain kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:28,113,024...28,128,142
Ensembl chr20:29,243,391...29,258,508 		JBrowse link
regulation of muscle filament sliding speed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNNC1 troponin C1, slow skeletal and cardiac type involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,393,106...52,396,076
Ensembl chr 3:53,621,749...53,624,726 		JBrowse link
G TNNT2 troponin T2, cardiac type involved_in ISO PMID:10747195 BHF-UCL PMID:10747195 RGD:8554013 NCBI chr 1:176,957,298...176,976,033 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    multicellular organismal process 7357
      system process 2241
        muscle system process 466
          muscle contraction 332
            muscle filament sliding 8
              negative regulation of muscle filament sliding 1
              positive regulation of muscle filament sliding 0
              regulation of muscle filament sliding + 4
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18871
      actin filament-based process 795
        actin filament-based movement 125
          actin-mediated cell contraction 103
            actin-myosin filament sliding 9
              muscle filament sliding 8
                negative regulation of muscle filament sliding 1
                positive regulation of muscle filament sliding 0
                regulation of muscle filament sliding + 4
paths to the root