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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity

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show annotations for term's descendants           Sort by:
wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsdma gasdermin A enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:15,105,030...15,115,007
Ensembl chrNW_004936490:15,105,030...15,114,599 		JBrowse link
G Gsdmb gasdermin B enables ISO (PMID:32299851), (PMID:34022140), (PMID:36599845), (PMID:36899106), (PMID:36991122), (PMID:36991125) UniProt PMID:32299851 PMID:34022140 PMID:36599845 PMID:36899106 PMID:36991122 More... NCBI chrNW_004936490:15,058,009...15,066,781 JBrowse link
G Gsdmc gasdermin C enables ISO (PMID:32929201), (PMID:34012073)
(PMID:34290141)		 UniProt PMID:32929201 PMID:34012073 PMID:34290141 NCBI chrNW_004936470:18,840,455...18,856,022
Ensembl chrNW_004936470:18,843,579...18,855,639 		JBrowse link
G Gsdmd gasdermin D enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:8,567,085...8,571,448
Ensembl chrNW_004936470:8,567,091...8,571,467 		JBrowse link
G Gsdme gasdermin E enables ISO (PMID:28459430), (PMID:32188940), (PMID:33852854), (PMID:35594856) UniProt PMID:28459430 PMID:32188940 PMID:33852854 PMID:35594856 NCBI chrNW_004936478:1,655,487...1,720,996 JBrowse link
G Mpeg1 macrophage expressed 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:3,428,515...3,436,877
Ensembl chrNW_004936581:3,421,256...3,431,706 		JBrowse link
G Panx1 pannexin 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936674:736,911...773,406
Ensembl chrNW_004936674:736,905...773,412 		JBrowse link
G Panx2 pannexin 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936629:618,758...626,446
Ensembl chrNW_004936629:618,042...626,452 		JBrowse link
G Panx3 pannexin 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936743:1,083,217...1,092,023
Ensembl chrNW_004936743:1,083,227...1,090,777 		JBrowse link
G Prf1 perforin 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936521:8,057,874...8,060,695
Ensembl chrNW_004936521:8,057,874...8,060,695 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000107 GO_REF:0000118 RGD:1580399 RGD:1582674 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gja10 gap junction protein alpha 10 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936510:2,380,114...2,395,781
Ensembl chrNW_004936510:2,379,892...2,395,851 		JBrowse link
G Gja3 gap junction protein alpha 3 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000118 RGD:728416 NCBI chrNW_004936720:1,564,680...1,586,379
Ensembl chrNW_004936720:1,583,588...1,584,904 		JBrowse link
G Gja4 gap junction protein alpha 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:17,439,250...17,440,829
Ensembl chrNW_004936474:17,439,327...17,440,331 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Gja8 gap junction protein alpha 8 contributes_to
enables		 ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16123426 GO_REF:0000107 GO_REF:0000118 RGD:1598965 NCBI chrNW_004936867:374,638...378,080
Ensembl chrNW_004936867:374,638...375,933 		JBrowse link
G Gja9 gap junction protein alpha 9 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:20,866,678...20,871,540
Ensembl chrNW_004936474:20,867,307...20,868,848 		JBrowse link
G Gjb1 gap junction protein beta 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12119284 GO_REF:0000118 RGD:728476 NCBI chrNW_004936762:389,655...398,035
Ensembl chrNW_004936762:389,669...395,898 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:23232329 GO_REF:0000107 GO_REF:0000118 RGD:7349364 NCBI chrNW_004936720:1,528,205...1,530,296
Ensembl chrNW_004936720:1,528,249...1,528,929 		JBrowse link
G Gjb3 gap junction protein beta 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:17,427,255...17,431,368
Ensembl chrNW_004936474:17,429,926...17,430,729 		JBrowse link
G Gjb4 gap junction protein beta 4 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:17,407,209...17,409,657
Ensembl chrNW_004936474:17,408,623...17,409,423 		JBrowse link
G Gjb5 gap junction protein beta 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:17,402,804...17,406,080
Ensembl chrNW_004936474:17,405,000...17,405,809 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936720:1,485,895...1,494,673
Ensembl chrNW_004936720:1,493,733...1,494,518 		JBrowse link
G Gjb7 gap junction protein beta 7 enables ISO (PMID:12064583) UniProt PMID:12064583 NCBI chrNW_004936510:4,540,513...4,541,165 JBrowse link
G Gjc1 gap junction protein gamma 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:11668048 GO_REF:0000118 RGD:628534 NCBI chrNW_004936541:1,177,581...1,182,967
Ensembl chrNW_004936541:1,178,493...1,182,967 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936864:67,608...71,543
Ensembl chrNW_004936864:69,445...70,752 		JBrowse link
G Gjc3 gap junction protein gamma 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936543:73,253...74,065
Ensembl chrNW_004936543:71,138...74,065 		JBrowse link
G Gjd2 gap junction protein delta 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936673:1,129,750...1,133,229
Ensembl chrNW_004936673:1,128,930...1,134,905 		JBrowse link
G Gjd3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chrNW_004936490:15,426,699...15,429,789
Ensembl chrNW_004936490:15,427,263...15,428,141 		JBrowse link
G Gjd4 gap junction protein delta 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936574:3,878,436...3,881,704
Ensembl chrNW_004936574:3,878,383...3,881,718 		JBrowse link
G Gje1 gap junction protein epsilon 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936625:3,838,128...3,840,159
Ensembl chrNW_004936625:3,837,700...3,840,234 		JBrowse link
G Panx1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004936674:736,911...773,406
Ensembl chrNW_004936674:736,905...773,412 		JBrowse link
G Panx2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004936629:618,758...626,446
Ensembl chrNW_004936629:618,042...626,452 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700), (PMID:20606116), (PMID:23348765) BHF-UCL PMID:16790700 PMID:20606116 PMID:23348765 NCBI chrNW_004936867:269,477...279,549 JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482) BHF-UCL PMID:22247482 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Gjc1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936541:1,177,581...1,182,967
Ensembl chrNW_004936541:1,178,493...1,182,967 		JBrowse link
G Gjd3 gap junction protein delta 3 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:15,426,699...15,429,789
Ensembl chrNW_004936490:15,427,263...15,428,141 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482)
(PMID:26786475)		 BHF-UCL PMID:22247482 PMID:26786475 NCBI chrNW_004936867:269,477...279,549 JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700)
(PMID:23348765)		 BHF-UCL PMID:16790700 PMID:23348765 NCBI chrNW_004936867:269,477...279,549 JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gjb2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:1,528,205...1,530,296
Ensembl chrNW_004936720:1,528,249...1,528,929 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:1,485,895...1,494,673
Ensembl chrNW_004936720:1,493,733...1,494,518 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936864:67,608...71,543
Ensembl chrNW_004936864:69,445...70,752 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gja3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936720:1,564,680...1,586,379
Ensembl chrNW_004936720:1,583,588...1,584,904 		JBrowse link
G Gja5 gap junction protein alpha 5 enables ISO (PMID:23348765) BHF-UCL PMID:23348765 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Panx1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chrNW_004936674:736,911...773,406
Ensembl chrNW_004936674:736,905...773,412 		JBrowse link
G Panx3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936743:1,083,217...1,092,023
Ensembl chrNW_004936743:1,083,227...1,090,777 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2 antagonist/killer 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936476:25,347,608...25,354,772
Ensembl chrNW_004936476:25,347,545...25,355,789 		JBrowse link
G Vdac1 voltage dependent anion channel 1 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004936647:1,220,075...1,249,579
Ensembl chrNW_004936647:1,230,450...1,249,814 		JBrowse link
G Vdac2 voltage dependent anion channel 2 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004936521:4,122,447...4,136,228
Ensembl chrNW_004936521:4,122,270...4,136,380 		JBrowse link
G Vdac3 voltage dependent anion channel 3 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004936785:294,890...308,245
Ensembl chrNW_004936785:291,341...308,241 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17128
    transporter activity 1143
      transmembrane transporter activity 1051
        passive transmembrane transporter activity 483
          channel activity 483
            wide pore channel activity 35
              gap junction channel activity + 24
              gap junction hemi-channel activity 5
              porin activity + 4
paths to the root