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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity


show annotations for term's descendants           Sort by:
wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSDMA gasdermin A enables IEA Ensembl GO_REF:0000107 NCBI chr12:22,364,457...22,379,123
Ensembl chr12:22,363,376...22,379,068 		JBrowse link
G GSDMB gasdermin B enables ISO (PMID:32299851), (PMID:34022140), (PMID:36599845), (PMID:36899106), (PMID:36991122), (PMID:36991125) UniProt PMID:32299851 PMID:34022140 PMID:36599845 PMID:36899106 PMID:36991122 More... NCBI chr12:22,418,672...22,434,428
Ensembl chr12:22,418,747...22,436,086 		JBrowse link
G GSDMD gasdermin D enables IEA Ensembl GO_REF:0000107 NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271 		JBrowse link
G GSDME gasdermin E enables IEA Ensembl GO_REF:0000107 NCBI chr18:47,524,637...47,583,748
Ensembl chr18:47,526,797...47,583,731 		JBrowse link
G LOC100151870 gasdermin-C enables ISO (PMID:32929201), (PMID:34012073)
(PMID:34290141)		 UniProt PMID:32929201 PMID:34012073 PMID:34290141 NCBI chr 4:10,724,754...10,744,226 JBrowse link
G LOC110259471 macrophage-expressed gene 1 protein-like enables ISO (PMID:32064340), (PMID:36245269), (PMID:37347855) UniProt PMID:32064340 PMID:36245269 PMID:37347855 NCBI chr 2:12,472,927...12,475,116 JBrowse link
G MPEG1 macrophage expressed 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:12,194,303...12,196,594
Ensembl chr 2:12,194,327...12,198,351 		JBrowse link
G PANX1 pannexin 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 9:26,443,425...26,491,010
Ensembl chr 9:26,443,815...26,491,002 		JBrowse link
G PANX2 pannexin 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 5:497,380...506,126
Ensembl chr 5:497,385...506,013 		JBrowse link
G PRF1 perforin 1 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:73,515,306...73,520,256
Ensembl chr14:73,512,769...73,520,202 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000033 GO_REF:0000107 RGD:1580399 RGD:1582674 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:57,879,740...57,881,395
Ensembl chr 1:57,868,387...57,893,687 		JBrowse link
G GJA3 gap junction protein alpha 3 enables ISO
IBA		 RGD
GO_Central		 PMID:1659572 GO_REF:0000033 RGD:728416 NCBI chr11:750,658...751,889
Ensembl chr11:750,658...751,800 		JBrowse link
G GJA4 gap junction protein alpha 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:91,045,430...91,048,161
Ensembl chr 6:91,045,394...91,048,162 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:16123426 GO_REF:0000033 GO_REF:0000107 RGD:1598965 NCBI chr 4:99,721,754...99,724,943
Ensembl chr 4:99,723,341...99,724,672 		JBrowse link
G GJA9 gap junction protein alpha 9 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:94,815,105...94,817,183
Ensembl chr 6:94,815,600...94,817,147 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IBA		 RGD
GO_Central		 PMID:12119284 GO_REF:0000033 RGD:728476 NCBI chr  X:57,241,990...57,249,496
Ensembl chr  X:57,242,045...57,249,885 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IEA		 RGD
Ensembl		 PMID:23232329 GO_REF:0000107 RGD:7349364 NCBI chr11:774,090...781,252
Ensembl chr11:775,166...775,846 		JBrowse link
G GJB3 gap junction protein beta 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:91,031,378...91,037,548
Ensembl chr 6:91,031,849...91,037,542 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:91,004,794...91,008,231
Ensembl chr 6:91,007,200...91,008,000 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr11:793,276...800,109
Ensembl chr11:793,280...800,046 		JBrowse link
G GJB7 gap junction protein beta 7 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:55,729,842...55,741,209
Ensembl chr 1:55,730,903...55,731,691 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IBA		 RGD
GO_Central		 PMID:11668048 GO_REF:0000033 RGD:628534 NCBI chr12:18,526,060...18,560,221
Ensembl chr12:18,526,595...18,560,218 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:51,257,623...51,267,969
Ensembl chr 2:51,258,207...51,267,962 		JBrowse link
G GJC3 gap junction protein gamma 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 3:7,843,398...7,849,864
Ensembl chr 3:7,839,151...7,848,761 		JBrowse link
G GJD2 gap junction protein delta 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:136,310,759...136,328,060
Ensembl chr 1:136,324,192...136,327,347 		JBrowse link
G GJD3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chr12:22,040,312...22,044,238 JBrowse link
G GJD4 gap junction protein delta 4 enables IBA GO_Central GO_REF:0000033 NCBI chr10:58,069,679...58,076,738 JBrowse link
G GJE1 gap junction protein epsilon 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:22,933,885...22,936,167
Ensembl chr 1:22,933,885...22,935,121 		JBrowse link
G PANX1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chr 9:26,443,425...26,491,010
Ensembl chr 9:26,443,815...26,491,002 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr 5:497,380...506,126
Ensembl chr 5:497,385...506,013 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:18,526,060...18,560,221
Ensembl chr12:18,526,595...18,560,218 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr12:22,040,312...22,044,238 JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJB2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr11:774,090...781,252
Ensembl chr11:775,166...775,846 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr11:793,276...800,109
Ensembl chr11:793,280...800,046 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:51,257,623...51,267,969
Ensembl chr 2:51,258,207...51,267,962 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJA3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chr11:750,658...751,889
Ensembl chr11:750,658...751,800 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr 9:26,443,425...26,491,010
Ensembl chr 9:26,443,815...26,491,002 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:51,854,148...51,860,330
Ensembl chr 9:51,853,949...51,861,331 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:29,808,849...29,815,345
Ensembl chr 7:29,808,849...29,815,318 		JBrowse link
G SAMD8 sterile alpha motif domain containing 8 enables IEA UniProt GO_REF:0000043 NCBI chr14:77,679,287...77,737,657
Ensembl chr14:77,636,149...77,737,654 		JBrowse link
G VDAC1 voltage dependent anion channel 1 enables IEA UniProt GO_REF:0000043 NCBI chr 2:136,302,188...136,334,461
Ensembl chr 2:136,302,191...136,396,301 		JBrowse link
G VDAC2 voltage dependent anion channel 2 enables IEA UniProt GO_REF:0000043 NCBI chr14:77,767,165...77,782,327
Ensembl chr14:77,766,686...77,782,321 		JBrowse link
G VDAC3 voltage dependent anion channel 3 enables IEA UniProt GO_REF:0000043 NCBI chr17:11,410,313...11,425,395
Ensembl chr17:11,410,472...11,425,382 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18634
    transporter activity 1193
      transmembrane transporter activity 1096
        passive transmembrane transporter activity 499
          channel activity 499
            wide pore channel activity 36
              gap junction channel activity + 23
              gap junction hemi-channel activity 5
              porin activity + 5
paths to the root