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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity

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wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsdma gasdermin A enables ISO (PMID:35110732), (PMID:35545676) UniProt PMID:35110732 PMID:35545676 NCBI chrNW_004624795:3,182,256...3,191,744
Ensembl chrNW_004624795:3,182,512...3,190,640 		JBrowse link
G Gsdmc gasdermin C enables ISO (PMID:32929201), (PMID:34012073)
(PMID:34290141)		 UniProt PMID:32929201 PMID:34012073 PMID:34290141 NCBI chrNW_004624735:25,913,246...25,955,621 JBrowse link
G Gsdmd gasdermin D enables ISO (PMID:32109412), (PMID:32820063), (PMID:33883744), (PMID:35794369), (PMID:38040708), (PMID:38530158), (PMID:38599239)
(PMID:27339137), (PMID:27383986), (PMID:29195811), (PMID:29274245), (PMID:32820063), (PMID:33883744), (PMID:35705808), (PMID:35749514), (PMID:35794369), (PMID:38538834), (PMID:38632402)		 UniProt PMID:27339137 PMID:27383986 PMID:29195811 PMID:29274245 PMID:32109412 More... NCBI chrNW_004624735:13,187,810...13,192,843
Ensembl chrNW_004624735:13,187,687...13,192,736 		JBrowse link
G Gsdme gasdermin E enables ISO (PMID:28459430), (PMID:32188940), (PMID:33852854), (PMID:35594856) UniProt PMID:28459430 PMID:32188940 PMID:33852854 PMID:35594856 NCBI chrNW_004624739:5,790,372...5,879,979
Ensembl chrNW_004624739:5,798,771...5,871,088 		JBrowse link
G Mpeg1 macrophage expressed 1 enables ISO (PMID:31537793)
(PMID:32064340), (PMID:36245269), (PMID:37347855)		 UniProt PMID:31537793 PMID:32064340 PMID:36245269 PMID:37347855 NCBI chrNW_004624864:1,470,862...1,474,957
Ensembl chrNW_004624864:1,470,887...1,473,046 		JBrowse link
G Panx1 pannexin 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:38,766,973...38,823,284
Ensembl chrNW_004624735:38,766,981...38,819,092 		JBrowse link
G Panx2 pannexin 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624752:565,357...575,064
Ensembl chrNW_004624752:565,357...575,069 		JBrowse link
G Panx3 pannexin 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624927:612,686...621,282
Ensembl chrNW_004624927:612,750...620,564 		JBrowse link
G Prf1 perforin 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:4,679,451...4,681,627
Ensembl chrNW_004624754:4,679,521...4,681,627 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000107 GO_REF:0000118 RGD:1580399 RGD:1582674 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gja10 gap junction protein alpha 10 enables ISO (PMID:10329667) MGI PMID:10329667 NCBI chrNW_004624799:4,278,097...4,279,588 JBrowse link
G Gja3 gap junction protein alpha 3 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000118 RGD:728416 NCBI chrNW_004624776:17,562,050...17,585,308
Ensembl chrNW_004624776:17,579,913...17,581,121 		JBrowse link
G Gja4 gap junction protein alpha 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:17,842,566...17,845,011
Ensembl chrNW_004624764:17,836,180...17,845,011 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Gja8 gap junction protein alpha 8 contributes_to
enables		 ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16123426 GO_REF:0000107 GO_REF:0000118 RGD:1598965 NCBI chrNW_004624772:16,959,615...16,960,937
Ensembl chrNW_004624772:16,959,615...16,960,937 		JBrowse link
G Gjb1 gap junction protein beta 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12119284 GO_REF:0000118 RGD:728476 NCBI chrNW_004624903:1,511,347...1,519,265
Ensembl chrNW_004624903:1,517,324...1,519,265 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO
IEA		 RGD
TreeGrafter		 PMID:23232329 GO_REF:0000118 RGD:7349364 NCBI chrNW_004624776:17,517,824...17,522,683
Ensembl chrNW_004624776:17,518,284...17,522,936 		JBrowse link
G Gjb3 gap junction protein beta 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:17,829,214...17,833,509
Ensembl chrNW_004624764:17,829,467...17,833,465 		JBrowse link
G Gjb4 gap junction protein beta 4 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624764:17,812,152...17,814,987
Ensembl chrNW_004624764:17,813,922...17,814,722 		JBrowse link
G Gjb5 gap junction protein beta 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:17,807,943...17,811,404
Ensembl chrNW_004624764:17,808,161...17,811,372 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624776:17,477,947...17,487,304
Ensembl chrNW_004624776:17,477,966...17,487,303 		JBrowse link
G Gjb7 gap junction protein beta 7 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624799:7,053,954...7,067,571
Ensembl chrNW_004624799:7,057,990...7,065,205 		JBrowse link
G Gjc1 gap junction protein gamma 1 ISO RGD PMID:11668048 RGD:628534 NCBI chrNW_004624795:443,234...466,222
Ensembl chrNW_004624795:461,691...464,454 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:11160382) MGI PMID:11160382 NCBI chrNW_004624937:898,876...905,247 JBrowse link
G Gjd2 gap junction protein delta 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624804:1,962,597...1,965,598
Ensembl chrNW_004624804:1,961,865...1,965,673 		JBrowse link
G Gjd3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chrNW_004624795:2,930,425...2,933,411
Ensembl chrNW_004624795:2,930,925...2,931,767 		JBrowse link
G Gjd4 gap junction protein delta 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624805:10,006,548...10,009,592
Ensembl chrNW_004624805:10,006,616...10,009,618 		JBrowse link
G Panx1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004624735:38,766,973...38,823,284
Ensembl chrNW_004624735:38,766,981...38,819,092 		JBrowse link
G Panx2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004624752:565,357...575,064
Ensembl chrNW_004624752:565,357...575,069 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Gjc1 gap junction protein gamma 1 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chrNW_004624795:443,234...466,222
Ensembl chrNW_004624795:461,691...464,454 		JBrowse link
G Gjd3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chrNW_004624795:2,930,425...2,933,411
Ensembl chrNW_004624795:2,930,925...2,931,767 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004624776:17,517,824...17,522,683
Ensembl chrNW_004624776:17,518,284...17,522,936 		JBrowse link
G Gjb6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624776:17,477,947...17,487,304
Ensembl chrNW_004624776:17,477,966...17,487,303 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:17344063) UniProt PMID:17344063 NCBI chrNW_004624937:898,876...905,247 JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gja3 gap junction protein alpha 3 enables ISO PMID:17715132
(PMID:30044662)		 UniProt PMID:17715132 PMID:30044662 RGD:15090844 NCBI chrNW_004624776:17,562,050...17,585,308
Ensembl chrNW_004624776:17,579,913...17,581,121 		JBrowse link
G Gja5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Panx1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chrNW_004624735:38,766,973...38,823,284
Ensembl chrNW_004624735:38,766,981...38,819,092 		JBrowse link
G Panx3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624927:612,686...621,282
Ensembl chrNW_004624927:612,750...620,564 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2 antagonist/killer 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:23,297,077...23,302,366
Ensembl chrNW_004624754:23,296,800...23,301,223 		JBrowse link
G Vdac1 voltage dependent anion channel 1 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624733:38,183,376...38,210,368
Ensembl chrNW_004624733:38,184,016...38,210,478 		JBrowse link
G Vdac2 voltage dependent anion channel 2 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624754:8,587,698...8,601,757
Ensembl chrNW_004624754:8,587,920...8,602,761 		JBrowse link
G Vdac3 voltage dependent anion channel 3 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624780:857,985...870,009
Ensembl chrNW_004624780:857,686...869,952 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16462
    transporter activity 1084
      transmembrane transporter activity 993
        passive transmembrane transporter activity 463
          channel activity 463
            wide pore channel activity 31
              gap junction channel activity + 21
              gap junction hemi-channel activity 5
              porin activity + 4
paths to the root