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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity


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wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsdma gasdermin A enables ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr11:98,555,163...98,568,534
Ensembl chr11:98,555,177...98,568,534 		JBrowse link
G Gsdma2 gasdermin A2 enables ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr11:98,537,569...98,548,791
Ensembl chr11:98,537,585...98,548,790 		JBrowse link
G Gsdma3 gasdermin A3 enables ISO
IDA		 (PMID:27281216), (PMID:29695864), (PMID:33883744), (PMID:35545613) GO_Central
UniProt		 PMID:27281216 PMID:29695864 PMID:33883744 PMID:35545613 GO_REF:0000119 NCBI chr11:98,517,175...98,529,627
Ensembl chr11:98,517,186...98,529,052 		JBrowse link
G Gsdmc gasdermin C enables ISO GO_Central GO_REF:0000119 NCBI chr15:63,647,820...63,680,588
Ensembl chr15:63,647,817...63,680,608 		JBrowse link
G Gsdmc2 gasdermin C2 enables IDA
ISO		 (PMID:34290141) UniProt
GO_Central		 PMID:34290141 GO_REF:0000119 NCBI chr15:63,696,177...63,717,042
Ensembl chr15:63,696,195...63,717,026 		JBrowse link
G Gsdmc3 gasdermin C3 enables ISO GO_Central GO_REF:0000119 NCBI chr15:63,729,454...63,750,428
Ensembl chr15:63,729,573...63,750,407 		JBrowse link
G Gsdmc4 gasdermin C4 enables ISO GO_Central GO_REF:0000119 NCBI chr15:63,762,989...63,784,168
Ensembl chr15:63,763,113...63,784,146 		JBrowse link
G Gsdmd gasdermin D enables ISO
IDA		 (PMID:27339137), (PMID:27383986), (PMID:29195811), (PMID:29274245), (PMID:32820063), (PMID:33883744), (PMID:35705808), (PMID:35749514), (PMID:35794369), (PMID:38538834), (PMID:38632402) GO_Central
UniProt		 PMID:27339137 PMID:27383986 PMID:29195811 PMID:29274245 PMID:32820063 More... GO_REF:0000119 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Gsdme gasdermin E enables ISO
ISS
IEA		 GO_Central
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 GO_REF:0000119 NCBI chr 6:50,167,013...50,240,837
Ensembl chr 6:50,165,868...50,240,842 		JBrowse link
G Mpeg1 macrophage expressed gene 1 enables ISO
IDA		 (PMID:32064340), (PMID:36245269), (PMID:37347855) GO_Central
UniProt		 PMID:32064340 PMID:36245269 PMID:37347855 GO_REF:0000119 NCBI chr19:12,438,134...12,442,649
Ensembl chr19:12,438,143...12,442,649 		JBrowse link
G Panx1 pannexin 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 9:14,917,081...14,956,774
Ensembl chr 9:14,913,424...14,956,774 		JBrowse link
G Panx2 pannexin 2 enables IBA GO_Central GO_REF:0000033 NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770 		JBrowse link
G Panx3 pannexin 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 9:37,571,198...37,580,518
Ensembl chr 9:37,571,198...37,580,531 		JBrowse link
G Pfpl pore forming protein-like enables ISO GO_Central GO_REF:0000119 NCBI chr19:12,405,290...12,409,474
Ensembl chr19:12,405,269...12,409,474 		JBrowse link
G Prf1 perforin 1 (pore forming protein) enables ISO
IBA
IDA		 (PMID:21037563), (PMID:26306037), (PMID:35148176), (PMID:35705808) GO_Central
UniProt		 PMID:21037563 PMID:26306037 PMID:35148176 PMID:35705808 GO_REF:0000033 GO_REF:0000119 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISO
IBA
IMP
IDA		 (PMID:29366904)
(PMID:11397787), (PMID:15084279)		 RGD
GO_Central
UniProt
MGI		 PMID:11397787 PMID:15048573 PMID:15084279 PMID:16731531 PMID:29366904 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1580399 RGD:1582674 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja10 gap junction protein, alpha 10 enables IDA
IBA		 (PMID:10329667) MGI
GO_Central		 PMID:10329667 GO_REF:0000033 NCBI chr 4:32,594,595...32,607,382
Ensembl chr 4:32,596,960...32,602,760 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables ISO
IBA		 RGD
GO_Central		 PMID:1659572 GO_REF:0000033 GO_REF:0000096 RGD:728416 NCBI chr14:57,271,917...57,295,487
Ensembl chr14:57,271,917...57,295,557 		JBrowse link
G Gja4 gap junction protein, alpha 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:127,205,213...127,207,832
Ensembl chr 4:127,205,214...127,207,832 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO RGD
GO_Central		 PMID:1328644 GO_REF:0000096 RGD:728713 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr  X:159,685,112...159,690,048
Ensembl chr  X:159,685,112...159,690,048 		JBrowse link
G Gja8 gap junction protein, alpha 8 enables
contributes_to		 ISO
IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 NCBI chr 3:96,820,882...96,833,367
Ensembl chr 3:96,820,882...96,833,336 		JBrowse link
G Gjb1 gap junction protein, beta 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:12119284 GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 RGD:728476 NCBI chr  X:100,419,982...100,429,235
Ensembl chr  X:100,419,984...100,429,235 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables ISO
IBA
IDA		 (PMID:15692151) RGD
GO_Central
UniProt		 PMID:15692151 PMID:23232329 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:7349364 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Gjb3 gap junction protein, beta 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:127,219,028...127,224,633
Ensembl chr 4:127,219,028...127,224,637 		JBrowse link
G Gjb4 gap junction protein, beta 4 enables IDA
IBA		 (PMID:15692151) UniProt
GO_Central		 PMID:15692151 GO_REF:0000033 NCBI chr 4:127,234,892...127,247,929
Ensembl chr 4:127,244,879...127,247,874 		JBrowse link
G Gjb5 gap junction protein, beta 5 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:127,248,600...127,251,957
Ensembl chr 4:127,248,602...127,251,974 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables ISO
IBA		 RGD
GO_Central		 PMID:11668048 GO_REF:0000033 GO_REF:0000096 RGD:628534 NCBI chr11:102,690,303...102,710,512
Ensembl chr11:102,690,405...102,710,526 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables IDA
IBA		 (PMID:11160382) MGI
GO_Central		 PMID:11160382 GO_REF:0000033 NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039 		JBrowse link
G Gjc3 gap junction protein, gamma 3 enables ISA
IBA		 (PMID:11501764) MGI
GO_Central		 PMID:11501764 GO_REF:0000033 NCBI chr 5:137,949,254...137,961,360
Ensembl chr 5:137,951,723...137,961,360 		JBrowse link
G Gjd2 gap junction protein, delta 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 2:113,840,086...113,844,555
Ensembl chr 2:113,840,082...113,844,100 		JBrowse link
G Gjd3 gap junction protein, delta 3 enables ISO RGD
GO_Central		 PMID:23385797 GO_REF:0000096 RGD:7364769 NCBI chr11:98,870,773...98,873,846
Ensembl chr11:98,873,006...98,873,842 		JBrowse link
G Gjd4 gap junction protein, delta 4 enables IBA GO_Central GO_REF:0000033 NCBI chr18:9,278,124...9,289,808
Ensembl chr18:9,278,607...9,282,809 		JBrowse link
G Gje1 gap junction protein, epsilon 1 enables IBA GO_Central GO_REF:0000033 NCBI chr10:14,591,365...14,593,958
Ensembl chr10:14,591,367...14,593,958 		JBrowse link
G Panx1 pannexin 1 enables ISO RGD
GO_Central		 PMID:14597722 GO_REF:0000096 RGD:1299639 NCBI chr 9:14,917,081...14,956,774
Ensembl chr 9:14,913,424...14,956,774 		JBrowse link
G Panx2 pannexin 2 enables ISO RGD
GO_Central		 PMID:14597722 GO_REF:0000096 RGD:1299639 NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables IBA
ISO		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO GO_Central GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables IMP (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr11:102,690,303...102,710,512
Ensembl chr11:102,690,405...102,710,526 		JBrowse link
G Gjd3 gap junction protein, delta 3 enables IBA
IMP		 (PMID:22982984) GO_Central
BHF-UCL		 PMID:22982984 GO_REF:0000033 NCBI chr11:98,870,773...98,873,846
Ensembl chr11:98,873,006...98,873,842 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO
IMP		 (PMID:26786475) GO_Central
BHF-UCL		 PMID:26786475 GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables TAS (PMID:26403541) UniProt PMID:26403541 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO GO_Central GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISO GO_Central GO_REF:0000119 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables ISO GO_Central GO_REF:0000119 NCBI chr  X:159,685,112...159,690,048
Ensembl chr  X:159,685,112...159,690,048 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000096 GO_REF:0000119 NCBI chr14:57,271,917...57,295,487
Ensembl chr14:57,271,917...57,295,557 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO GO_Central GO_REF:0000119 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables ISO GO_Central GO_REF:0000119 NCBI chr  X:159,685,112...159,690,048
Ensembl chr  X:159,685,112...159,690,048 		JBrowse link
G Panx1 pannexin 1 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr 9:14,917,081...14,956,774
Ensembl chr 9:14,913,424...14,956,774 		JBrowse link
G Panx2 pannexin 2 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770 		JBrowse link
G Panx3 pannexin 3 NOT|enables ISS
IDA		 (PMID:21690309) UniProt PMID:21690309 GO_REF:0000024 NCBI chr 9:37,571,198...37,580,518
Ensembl chr 9:37,571,198...37,580,531 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 enables IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 enables IEA UniProt GO_REF:0000043 NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363 		JBrowse link
G Tomm40l translocase of outer mitochondrial membrane 40-like enables IEA UniProt GO_REF:0000043 NCBI chr 1:171,043,579...171,050,020
Ensembl chr 1:171,043,580...171,050,083 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 enables IEA UniProt GO_REF:0000043 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 enables IEA UniProt GO_REF:0000043 NCBI chr14:21,881,629...21,895,947
Ensembl chr14:21,875,306...21,895,947 		JBrowse link
G Vdac3 voltage-dependent anion channel 3 enables IEA UniProt GO_REF:0000043 NCBI chr 8:23,067,091...23,083,829
Ensembl chr 8:23,067,102...23,083,774 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28792
    transporter activity 1221
      transmembrane transporter activity 1121
        passive transmembrane transporter activity 523
          channel activity 523
            wide pore channel activity 41
              gap junction channel activity + 23
              gap junction hemi-channel activity 7
              porin activity + 6
paths to the root