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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity


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wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSDMA gasdermin A enables IDA (PMID:35110732), (PMID:35545676) UniProt PMID:35110732 PMID:35545676 NCBI chr17:39,963,004...39,977,768
Ensembl chr17:39,953,263...39,977,768 		JBrowse link
G GSDMB gasdermin B enables IDA (PMID:32299851), (PMID:34022140), (PMID:36599845), (PMID:36899106), (PMID:36991122), (PMID:36991125) UniProt PMID:32299851 PMID:34022140 PMID:36599845 PMID:36899106 PMID:36991122 More... NCBI chr17:39,904,595...39,918,635
Ensembl chr17:39,904,595...39,919,854 		JBrowse link
G GSDMC gasdermin C enables IDA (PMID:32929201), (PMID:34012073) UniProt PMID:32929201 PMID:34012073 NCBI chr 8:129,705,435...129,786,624
Ensembl chr 8:129,748,196...129,786,624 		JBrowse link
G GSDMD gasdermin D enables IEA
IDA		 (PMID:32109412), (PMID:32820063), (PMID:33883744), (PMID:35794369), (PMID:38040708), (PMID:38530158), (PMID:38599239) Ensembl
UniProt		 PMID:32109412 PMID:32820063 PMID:33883744 PMID:35794369 PMID:38040708 More... GO_REF:0000107 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062 		JBrowse link
G GSDME gasdermin E enables IDA (PMID:28459430), (PMID:32188940), (PMID:33852854), (PMID:35594856) UniProt PMID:28459430 PMID:32188940 PMID:33852854 PMID:35594856 NCBI chr 7:24,698,355...24,795,539
Ensembl chr 7:24,698,355...24,757,940 		JBrowse link
G MPEG1 macrophage expressed 1 enables IDA (PMID:31537793) UniProt PMID:31537793 NCBI chr11:59,208,510...59,212,927
Ensembl chr11:59,208,510...59,212,927 		JBrowse link
G PANX1 pannexin 1 enables IBA GO_Central GO_REF:0000033 NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968 		JBrowse link
G PANX2 pannexin 2 enables IBA GO_Central GO_REF:0000033 NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295 		JBrowse link
G PANX3 pannexin 3 enables IBA GO_Central GO_REF:0000033 NCBI chr11:124,611,428...124,620,356
Ensembl chr11:124,611,428...124,620,356 		JBrowse link
G PRF1 perforin 1 enables IEA
IBA
IDA		 (PMID:20038786), (PMID:20889983), (PMID:24558045) Ensembl
GO_Central
UniProt		 PMID:20038786 PMID:20889983 PMID:24558045 GO_REF:0000033 GO_REF:0000107 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IBA
IEA
IDA		 (PMID:16790700), (PMID:1696265), (PMID:23348765), (PMID:29366904) RGD
GO_Central
Ensembl
BHF-UCL		 PMID:1696265 PMID:15048573 PMID:16731531 PMID:16790700 PMID:23348765 More... GO_REF:0000033 GO_REF:0000107 RGD:1580399 RGD:1582674 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:89,894,469...89,896,120
Ensembl chr 6:89,894,469...89,921,760 		JBrowse link
G GJA3 gap junction protein alpha 3 enables ISO
IBA
IEA		 RGD
GO_Central
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000033 RGD:728416 NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052 		JBrowse link
G GJA4 gap junction protein alpha 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:34,792,999...34,795,747
Ensembl chr 1:34,792,999...34,795,747 		JBrowse link
G GJA5 gap junction protein alpha 5 enables ISO
IEA		 RGD
Ensembl		 PMID:1328644 GO_REF:0000107 RGD:728713 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IBA
IDA
IEA		 (PMID:19756179) RGD
GO_Central
UniProt
Ensembl		 PMID:16123426 PMID:19756179 GO_REF:0000033 GO_REF:0000107 RGD:1598965 NCBI chr 1:147,902,795...147,914,486
Ensembl chr 1:147,902,795...147,909,269 		JBrowse link
G GJA9 gap junction protein alpha 9 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:38,874,069...38,881,587
Ensembl chr 1:38,874,069...38,881,587 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IBA
TAS
IEA		 RGD
GO_Central
Reactome
Ensembl		 PMID:12119284 GO_REF:0000033 GO_REF:0000107 RGD:728476 Reactome:R-HSA-190681 NCBI chr  X:71,215,239...71,225,516
Ensembl chr  X:71,212,811...71,225,516 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IBA
IDA
IEA		 (PMID:12767933), (PMID:21094651) RGD
GO_Central
ARUK-UCL
Ensembl		 PMID:12767933 PMID:21094651 PMID:23232329 GO_REF:0000033 GO_REF:0000107 RGD:7349364 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938 		JBrowse link
G GJB3 gap junction protein beta 3 enables NAS
IBA		 (PMID:9704026) UniProt
GO_Central		 PMID:9704026 GO_REF:0000033 NCBI chr 1:34,781,214...34,786,364
Ensembl chr 1:34,781,214...34,786,369 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA
IBA
ISS		 InterPro
GO_Central
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:34,759,740...34,762,327
Ensembl chr 1:34,759,740...34,762,327 		JBrowse link
G GJB5 gap junction protein beta 5 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:34,755,047...34,758,512
Ensembl chr 1:34,755,047...34,758,512 		JBrowse link
G GJB6 gap junction protein beta 6 enables IDA
IBA		 (PMID:12767933) ARUK-UCL
GO_Central		 PMID:12767933 GO_REF:0000033 NCBI chr13:20,221,962...20,232,319
Ensembl chr13:20,221,962...20,232,365 		JBrowse link
G GJB7 gap junction protein beta 7 enables IDA
IBA		 (PMID:12064583) UniProt
GO_Central		 PMID:12064583 GO_REF:0000033 NCBI chr 6:87,282,980...87,329,278
Ensembl chr 6:87,282,980...87,329,278 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:11668048 GO_REF:0000033 GO_REF:0000107 RGD:628534 NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:228,149,930...228,159,826
Ensembl chr 1:228,149,930...228,159,826 		JBrowse link
G GJC3 gap junction protein gamma 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:99,923,266...99,930,747
Ensembl chr 7:99,923,266...99,929,620 		JBrowse link
G GJD2 gap junction protein delta 2 enables IBA GO_Central GO_REF:0000033 NCBI chr15:34,751,032...34,754,998
Ensembl chr15:34,751,032...34,754,998 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO
IEA		 RGD
Ensembl		 PMID:23385797 GO_REF:0000107 RGD:7364769 NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737 		JBrowse link
G GJD4 gap junction protein delta 4 enables IBA GO_Central GO_REF:0000033 NCBI chr10:35,605,341...35,608,935
Ensembl chr10:35,605,341...35,608,935 		JBrowse link
G GJE1 gap junction protein epsilon 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:142,132,925...142,135,358
Ensembl chr 6:142,132,925...142,135,358 		JBrowse link
G PANX1 pannexin 1 enables ISO
IEA		 RGD
Ensembl		 PMID:14597722 GO_REF:0000107 RGD:1299639 NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IMP
IBA
NAS		 (PMID:16790700), (PMID:20606116), (PMID:23348765)
(PMID:15044680)		 BHF-UCL
GO_Central		 PMID:15044680 PMID:16790700 PMID:20606116 PMID:23348765 GO_REF:0000033 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IDA (PMID:22247482) BHF-UCL PMID:22247482 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816 		JBrowse link
G GJC3 gap junction protein gamma 3 NOT|enables NAS (PMID:21742272) BHF-UCL PMID:21742272 NCBI chr 7:99,923,266...99,930,747
Ensembl chr 7:99,923,266...99,929,620 		JBrowse link
G GJD3 gap junction protein delta 3 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IMP
ISS		 (PMID:22247482) BHF-UCL PMID:22247482 GO_REF:0000024 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables NAS (PMID:1696265) BHF-UCL PMID:1696265 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IDA
IMP		 (PMID:23348765)
(PMID:16790700)		 BHF-UCL PMID:16790700 PMID:23348765 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJD3 gap junction protein delta 3 NOT|enables NAS (PMID:19168070) BHF-UCL PMID:19168070 NCBI chr17:40,360,652...40,364,737
Ensembl chr17:40,360,652...40,364,737 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IDA (PMID:1696265) BHF-UCL PMID:1696265 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJB2 gap junction protein beta 2 enables IDA (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938 		JBrowse link
G GJB6 gap junction protein beta 6 enables IDA (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chr13:20,221,962...20,232,319
Ensembl chr13:20,221,962...20,232,365 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IMP (PMID:17344063) UniProt PMID:17344063 NCBI chr 1:228,149,930...228,159,826
Ensembl chr 1:228,149,930...228,159,826 		JBrowse link
gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables NAS (PMID:15044680) BHF-UCL PMID:15044680 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables NAS (PMID:15044680), (PMID:21357845) BHF-UCL PMID:15044680 PMID:21357845 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G GJC1 gap junction protein gamma 1 enables NAS (PMID:21357845) BHF-UCL PMID:21357845 NCBI chr17:44,794,104...44,831,364
Ensembl chr17:44,798,448...44,830,816 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IMP (PMID:29366904) UniProt PMID:29366904 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJA3 gap junction protein alpha 3 enables IDA (PMID:30044662) UniProt PMID:30044662 NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IDA (PMID:23348765) BHF-UCL PMID:23348765 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr11:94,128,841...94,181,968
Ensembl chr11:94,128,841...94,181,968 		JBrowse link
G PANX2 pannexin 2 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr22:50,170,731...50,180,295
Ensembl chr22:50,170,731...50,180,295 		JBrowse link
G PANX3 pannexin 3 NOT|enables ISS UniProt GO_REF:0000024 NCBI chr11:124,611,428...124,620,356
Ensembl chr11:124,611,428...124,620,356 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 enables IDA (PMID:22006182) UniProt PMID:22006182 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G TOMM40 translocase of outer mitochondrial membrane 40 enables IEA UniProt GO_REF:0000043 NCBI chr19:44,891,254...44,903,689
Ensembl chr19:44,890,569...44,903,689 		JBrowse link
G TOMM40L translocase of outer mitochondrial membrane 40 like enables IEA UniProt GO_REF:0000043 NCBI chr 1:161,226,060...161,230,746
Ensembl chr 1:161,225,939...161,230,746 		JBrowse link
G VDAC1 voltage dependent anion channel 1 enables IEA UniProt GO_REF:0000043 NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975 		JBrowse link
G VDAC2 voltage dependent anion channel 2 enables IEA UniProt GO_REF:0000043 NCBI chr10:75,210,170...75,231,448
Ensembl chr10:75,210,154...75,231,448 		JBrowse link
G VDAC3 voltage dependent anion channel 3 enables IEA UniProt GO_REF:0000043 NCBI chr 8:42,391,880...42,405,937
Ensembl chr 8:42,391,624...42,405,937 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19548
    transporter activity 1302
      transmembrane transporter activity 1183
        passive transmembrane transporter activity 535
          channel activity 535
            wide pore channel activity 37
              gap junction channel activity + 24
              gap junction hemi-channel activity 6
              porin activity + 6
paths to the root