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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity


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wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSDMA gasdermin A enables IEA Ensembl GO_REF:0000107 NCBI chr 9:22,555,834...22,569,141
Ensembl chr 9:22,556,192...22,566,849 		JBrowse link
G GSDMB gasdermin B enables ISO (PMID:32299851), (PMID:34022140), (PMID:36599845), (PMID:36899106), (PMID:36991122), (PMID:36991125) UniProt PMID:32299851 PMID:34022140 PMID:36599845 PMID:36899106 PMID:36991122 More... NCBI chr 9:22,604,358...22,616,540 JBrowse link
G GSDMC gasdermin C enables ISO (PMID:32929201), (PMID:34012073)
(PMID:34290141)		 UniProt PMID:32929201 PMID:34012073 PMID:34290141 NCBI chr13:26,906,167...26,919,599
Ensembl chr13:26,907,120...26,919,353 		JBrowse link
G GSDMD gasdermin D enables IEA Ensembl GO_REF:0000107 NCBI chr13:37,221,219...37,226,912
Ensembl chr13:37,193,022...37,228,360 		JBrowse link
G GSDME gasdermin E enables IEA Ensembl GO_REF:0000107 NCBI chr14:38,210,975...38,286,729
Ensembl chr14:38,211,540...38,292,280 		JBrowse link
G MPEG1 macrophage expressed 1 enables ISO (PMID:31537793)
(PMID:32064340), (PMID:36245269), (PMID:37347855)		 UniProt PMID:31537793 PMID:32064340 PMID:36245269 PMID:37347855 NCBI chr18:37,530,895...37,535,334
Ensembl chr18:37,531,032...37,533,179 		JBrowse link
G PRF1 perforin 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:21,497,865...21,502,429
Ensembl chr 4:21,498,249...21,500,864 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:15048573 PMID:16731531 GO_REF:0000033 GO_REF:0000107 RGD:1580399 RGD:1582674 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA Ensembl GO_REF:0000107 NCBI chr12:49,075,169...49,099,146
Ensembl chr12:49,092,747...49,097,743 		JBrowse link
G GJA3 gap junction protein alpha 3 ISO RGD PMID:1659572 RGD:728416 NCBI chr25:17,986,270...18,004,344
Ensembl chr25:18,002,817...18,004,160 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:16123426 GO_REF:0000033 GO_REF:0000107 RGD:1598965 NCBI chr17:58,360,313...58,428,751
Ensembl chr17:58,424,072...58,425,391 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IBA		 RGD
GO_Central		 PMID:12119284 GO_REF:0000033 RGD:728476 NCBI chr  X:55,565,995...55,575,332
Ensembl chr  X:55,573,808...55,574,659 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:23232329 GO_REF:0000033 GO_REF:0000107 RGD:7349364 NCBI chr25:17,952,851...17,958,289
Ensembl chr25:17,952,851...17,958,289 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr15:7,193,183...7,195,586 JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,912,036...17,922,310
Ensembl chr25:17,911,262...17,921,605 		JBrowse link
G GJB7 gap junction protein beta 7 enables IEA Ensembl GO_REF:0000107 NCBI chr12:46,800,875...46,812,896
Ensembl chr12:46,801,431...46,802,588 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IBA		 RGD
GO_Central		 PMID:11668048 GO_REF:0000033 RGD:628534 NCBI chr 9:18,642,359...18,688,128
Ensembl chr 9:18,686,527...18,687,717 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr14:810,388...819,248
Ensembl chr14:810,386...820,420 		JBrowse link
G GJD3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chr 9:22,246,891...22,248,597 JBrowse link
G PANX1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chr21:6,665,730...6,715,272
Ensembl chr21:6,668,269...6,715,858 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr10:17,052,972...17,059,756
Ensembl chr10:17,052,956...17,055,880 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:18,642,359...18,688,128
Ensembl chr 9:18,686,527...18,687,717 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr 9:22,246,891...22,248,597 JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJB2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,952,851...17,958,289
Ensembl chr25:17,952,851...17,958,289 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,912,036...17,922,310
Ensembl chr25:17,911,262...17,921,605 		JBrowse link
G GJC2 gap junction protein gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr14:810,388...819,248
Ensembl chr14:810,386...820,420 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJA3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chr25:17,986,270...18,004,344
Ensembl chr25:18,002,817...18,004,160 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr21:6,665,730...6,715,272
Ensembl chr21:6,668,269...6,715,858 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:9,787,513...9,794,292
Ensembl chr 5:9,787,947...9,794,166 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018 		JBrowse link
G LOC102152873 voltage-dependent anion-selective channel protein 1-like enables IEA UniProt GO_REF:0000043 NCBI chr 5:28,727,512...28,729,888 JBrowse link
G LOC119877842 voltage-dependent anion-selective channel protein 2 enables IEA UniProt GO_REF:0000043
G LOC475462 voltage dependent anion channel 3 pseudogene enables IEA UniProt GO_REF:0000043 NCBI chr15:48,056,720...48,058,048 JBrowse link
G VDAC1 voltage dependent anion channel 1 enables IEA UniProt GO_REF:0000043 NCBI chr11:22,197,814...22,212,924
Ensembl chr11:22,197,949...22,212,924 		JBrowse link
G VDAC2 voltage dependent anion channel 2 enables IEA UniProt GO_REF:0000043 NCBI chr 4:25,449,926...25,462,147
Ensembl chr 4:25,449,442...25,462,335 		JBrowse link
G VDAC3 voltage dependent anion channel 3 enables IEA UniProt GO_REF:0000043 NCBI chr16:23,276,763...23,289,752
Ensembl chr16:23,276,767...23,289,752 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18610
    transporter activity 1198
      transmembrane transporter activity 1105
        passive transmembrane transporter activity 485
          channel activity 485
            wide pore channel activity 31
              gap junction channel activity + 17
              gap junction hemi-channel activity 6
              porin activity + 7
paths to the root