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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity

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wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsdma gasdermin A enables ISO (PMID:35110732), (PMID:35545676) UniProt PMID:35110732 PMID:35545676 NCBI chrNW_004955451:14,650,342...14,663,609
Ensembl chrNW_004955451:14,650,344...14,663,609 		JBrowse link
G Gsdmc gasdermin C enables ISO (PMID:32929201), (PMID:34012073)
(PMID:34290141)		 UniProt PMID:32929201 PMID:34012073 PMID:34290141 NCBI chrNW_004955461:4,594,967...4,610,037 JBrowse link
G Gsdmd gasdermin D enables ISO (PMID:32109412), (PMID:32820063), (PMID:33883744), (PMID:35794369), (PMID:38040708), (PMID:38530158), (PMID:38599239)
(PMID:27339137), (PMID:27383986), (PMID:29195811), (PMID:29274245), (PMID:32820063), (PMID:33883744), (PMID:35705808), (PMID:35749514), (PMID:35794369), (PMID:38538834), (PMID:38632402)		 UniProt PMID:27339137 PMID:27383986 PMID:29195811 PMID:29274245 PMID:32109412 More... NCBI chrNW_004955454:2,265,759...2,270,569
Ensembl chrNW_004955454:2,265,753...2,271,655 		JBrowse link
G Gsdme gasdermin E enables ISO (PMID:28459430), (PMID:32188940), (PMID:33852854), (PMID:35594856) UniProt PMID:28459430 PMID:32188940 PMID:33852854 PMID:35594856 NCBI chrNW_004955410:26,700,977...26,761,683
Ensembl chrNW_004955410:26,701,893...26,769,989 		JBrowse link
G Mpeg1 macrophage expressed 1 enables ISO (PMID:31537793)
(PMID:32064340), (PMID:36245269), (PMID:37347855)		 UniProt PMID:31537793 PMID:32064340 PMID:36245269 PMID:37347855 NCBI chrNW_004955511:3,783,200...3,787,300
Ensembl chrNW_004955511:3,785,019...3,787,154 		JBrowse link
G Prf1 perforin 1 enables ISO (PMID:20038786), (PMID:20889983), (PMID:24558045)
(PMID:21037563), (PMID:26306037), (PMID:35148176), (PMID:35705808)		 UniProt PMID:20038786 PMID:20889983 PMID:21037563 PMID:24558045 PMID:26306037 More... NCBI chrNW_004955437:20,700,912...20,705,076
Ensembl chrNW_004955437:20,700,718...20,706,929 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO (PMID:29366904)
(PMID:11397787), (PMID:15084279)
(PMID:16790700), (PMID:1696265), (PMID:23348765), (PMID:29366904)
PMID:15284189		 RGD
UniProt
MGI
BHF-UCL
CAFA		 PMID:1696265 PMID:11397787 PMID:15048573 PMID:15084279 PMID:15284189 More... RGD:12793029 RGD:1580399 RGD:1582674 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gja10 gap junction protein alpha 10 enables ISO (PMID:10329667) MGI PMID:10329667 NCBI chrNW_004955411:16,586,673...16,601,999
Ensembl chrNW_004955411:16,593,576...16,595,042 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Gja8 gap junction protein alpha 8 contributes_to
enables		 ISO (PMID:19756179) RGD
UniProt		 PMID:16123426 PMID:19756179 RGD:1598965 NCBI chrNW_004955568:514,905...516,551
Ensembl chrNW_004955568:515,113...516,435 		JBrowse link
G Gjb1 gap junction protein beta 1 ISO RGD PMID:12119284 RGD:728476 NCBI chrNW_004955475:10,779,415...10,787,910
Ensembl chrNW_004955475:10,785,996...10,787,910 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO (PMID:15692151)
(PMID:12767933), (PMID:21094651)		 RGD
UniProt
ARUK-UCL		 PMID:12767933 PMID:15692151 PMID:21094651 PMID:23232329 RGD:7349364 NCBI chrNW_004955497:987,213...989,477
Ensembl chrNW_004955497:988,422...989,099 		JBrowse link
G Gjb4 gap junction protein beta 4 enables ISO (PMID:15692151) UniProt PMID:15692151 NCBI chrNW_004955452:12,871,548...12,874,019
Ensembl chrNW_004955452:12,871,548...12,874,019 		JBrowse link
G Gjb6 gap junction protein beta 6 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:1,018,610...1,027,593
Ensembl chrNW_004955497:1,018,610...1,027,360 		JBrowse link
G Gjb7 gap junction protein beta 7 enables ISO (PMID:12064583) UniProt PMID:12064583 NCBI chrNW_004955411:14,285,142...14,303,036 JBrowse link
G Gjc1 gap junction protein gamma 1 ISO RGD PMID:11668048 RGD:628534 NCBI chrNW_004955451:17,626,859...17,639,002
Ensembl chrNW_004955451:17,626,859...17,630,247 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:11160382) MGI PMID:11160382 NCBI chrNW_004955581:291,537...294,752 JBrowse link
G Panx1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004955414:405,483...448,470
Ensembl chrNW_004955414:401,188...448,470 		JBrowse link
G Panx2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chrNW_004955413:33,220,145...33,224,241
Ensembl chrNW_004955413:33,220,140...33,224,344 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700), (PMID:20606116), (PMID:23348765) BHF-UCL PMID:16790700 PMID:20606116 PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482) BHF-UCL PMID:22247482 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Gjc1 gap junction protein gamma 1 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chrNW_004955451:17,626,859...17,639,002
Ensembl chrNW_004955451:17,626,859...17,630,247 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:22247482)
(PMID:26786475)		 BHF-UCL PMID:22247482 PMID:26786475 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 enables ISO (PMID:16790700)
(PMID:23348765)		 BHF-UCL PMID:16790700 PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO (PMID:1696265) BHF-UCL PMID:1696265 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gjb2 gap junction protein beta 2 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:987,213...989,477
Ensembl chrNW_004955497:988,422...989,099 		JBrowse link
G Gjb6 gap junction protein beta 6 enables ISO (PMID:12767933) ARUK-UCL PMID:12767933 NCBI chrNW_004955497:1,018,610...1,027,593
Ensembl chrNW_004955497:1,018,610...1,027,360 		JBrowse link
G Gjc2 gap junction protein gamma 2 enables ISO (PMID:17344063) UniProt PMID:17344063 NCBI chrNW_004955581:291,537...294,752 JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein alpha 1 enables ISO (PMID:29366904) UniProt PMID:29366904 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gja5 gap junction protein alpha 5 enables ISO (PMID:23348765) BHF-UCL PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Panx1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chrNW_004955414:405,483...448,470
Ensembl chrNW_004955414:401,188...448,470 		JBrowse link
G Panx3 pannexin 3 enables ISO (PMID:21690309) UniProt PMID:21690309 NCBI chrNW_004955412:25,676,286...25,684,841
Ensembl chrNW_004955412:25,676,286...25,684,841 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2 antagonist/killer 1 enables ISO (PMID:22006182) UniProt PMID:22006182 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14366
    transporter activity 881
      transmembrane transporter activity 800
        passive transmembrane transporter activity 395
          channel activity 395
            wide pore channel activity 21
              gap junction channel activity + 14
              gap junction hemi-channel activity 4
              porin activity + 1
paths to the root