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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity


show annotations for term's descendants           Sort by:
wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSDMA gasdermin A enables IEA Ensembl GO_REF:0000107 NCBI chr17:17,311,932...17,324,004
Ensembl chr17:17,531,767...17,543,413 		JBrowse link
G GSDMB gasdermin B enables ISO (PMID:32299851), (PMID:34022140), (PMID:36599845), (PMID:36899106), (PMID:36991122), (PMID:36991125) UniProt PMID:32299851 PMID:34022140 PMID:36599845 PMID:36899106 PMID:36991122 More... NCBI chr17:17,370,351...17,384,639
Ensembl chr17:17,590,018...17,604,177 		JBrowse link
G GSDMC gasdermin C enables ISO (PMID:32929201), (PMID:34012073)
(PMID:34290141)		 UniProt PMID:32929201 PMID:34012073 PMID:34290141 NCBI chr 8:126,384,575...126,423,505
Ensembl chr 8:129,118,445...129,147,808 		JBrowse link
G GSDMD gasdermin D enables IEA Ensembl GO_REF:0000107 NCBI chr 8:140,311,042...140,316,084
Ensembl chr 8:143,326,319...143,331,455 		JBrowse link
G GSDME gasdermin E enables IEA Ensembl GO_REF:0000107 NCBI chr 7:25,373,485...25,433,001
Ensembl chr 7:24,977,838...25,039,525 		JBrowse link
G MPEG1 macrophage expressed 1 enables IEA Ensembl GO_REF:0000107 NCBI chr11:54,425,904...54,442,631
Ensembl chr11:57,880,109...57,882,259 		JBrowse link
G PANX1 pannexin 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr11:89,142,686...89,295,972
Ensembl chr11:92,628,760...92,685,109 		JBrowse link
G PANX2 pannexin 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr22:30,398,717...30,408,358
Ensembl chr22:49,404,624...49,408,045 		JBrowse link
G PANX3 pannexin 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr11:119,438,866...119,452,174
Ensembl chr11:123,354,919...123,363,463 		JBrowse link
G PRF1 perforin 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:67,071,141...67,078,057
Ensembl chr10:69,597,574...69,603,070 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:15048573 PMID:16731531 GO_REF:0000118 RGD:1580399 RGD:1582674 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA10 gap junction protein alpha 10 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:87,774,889...87,776,520
Ensembl chr 6:91,046,601...91,072,335 		JBrowse link
G GJA3 gap junction protein alpha 3 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1659572 GO_REF:0000002 GO_REF:0000118 RGD:728416 NCBI chr13:1,464,542...1,488,240
Ensembl chr13:19,784,372...19,785,679 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:1328644 RGD:728713 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G GJA8 gap junction protein alpha 8 contributes_to
enables		 ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16123426 GO_REF:0000107 GO_REF:0000118 RGD:1598965 NCBI chr 1:123,352,801...123,355,625
Ensembl chr 1:112,174,365...112,177,893 		JBrowse link
G GJA9 gap junction protein alpha 9 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:38,146,515...38,159,985
Ensembl chr 1:39,492,609...39,494,156 		JBrowse link
G GJB1 gap junction protein beta 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12119284 GO_REF:0000118 RGD:728476 NCBI chr  X:60,490,579...60,492,606
Ensembl chr  X:70,547,110...70,547,961 		JBrowse link
G GJB2 gap junction protein beta 2 enables ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:23232329 GO_REF:0000107 GO_REF:0000118 RGD:7349364 NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954 		JBrowse link
G GJB4 gap junction protein beta 4 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:34,027,433...34,029,415
Ensembl chr 1:35,209,877...35,210,677 		JBrowse link
G GJB5 gap junction protein beta 5 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:34,022,109...34,025,606
Ensembl chr 1:35,205,953...35,206,774 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr13:1,549,089...1,559,452
Ensembl chr13:19,864,939...19,865,724 		JBrowse link
G GJB7 gap junction protein beta 7 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:85,160,188...85,206,448
Ensembl chr 6:88,415,983...88,437,581 		JBrowse link
G GJC1 gap junction protein gamma 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:11668048 GO_REF:0000118 RGD:628534 NCBI chr17:12,492,285...12,524,615
Ensembl chr17:12,689,251...12,690,441 		JBrowse link
G GJC2 gap junction protein gamma 2 enables ISO (PMID:11160382) MGI PMID:11160382 NCBI chr 1:203,551,556...203,561,702 JBrowse link
G GJC3 gap junction protein gamma 3 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 7:91,956,757...91,963,417
Ensembl chr 7:105,390,567...105,396,643 		JBrowse link
G GJD2 gap junction protein delta 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:13,668,639...13,672,691
Ensembl chr15:31,928,157...31,931,474 		JBrowse link
G GJD3 gap junction protein delta 3 ISO RGD PMID:23385797 RGD:7364769 NCBI chr17:16,925,395...16,929,683 JBrowse link
G GJD4 gap junction protein delta 4 enables IEA TreeGrafter GO_REF:0000118 NCBI chr10:35,698,294...35,735,764
Ensembl chr10:36,306,919...36,322,448 		JBrowse link
G GJE1 gap junction protein epsilon 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 6:139,901,021...139,902,784
Ensembl chr 6:143,974,781...143,976,543 		JBrowse link
G LOC100975396 gap junction alpha-1 protein-like enables IEA TreeGrafter GO_REF:0000118 NCBI chr 5:104,401,975...104,403,855 JBrowse link
G LOC129397801 gap junction alpha-1 protein-like enables IEA TreeGrafter GO_REF:0000118
G PANX1 pannexin 1 ISO RGD PMID:14597722 RGD:1299639 NCBI chr11:89,142,686...89,295,972
Ensembl chr11:92,628,760...92,685,109 		JBrowse link
G PANX2 pannexin 2 ISO RGD PMID:14597722 RGD:1299639 NCBI chr22:30,398,717...30,408,358
Ensembl chr22:49,404,624...49,408,045 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G GJC1 gap junction protein gamma 1 enables IEA Ensembl GO_REF:0000107 NCBI chr17:12,492,285...12,524,615
Ensembl chr17:12,689,251...12,690,441 		JBrowse link
G GJD3 gap junction protein delta 3 enables ISO (PMID:22982984) BHF-UCL PMID:22982984 NCBI chr17:16,925,395...16,929,683 JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO (PMID:1696265) BHF-UCL PMID:1696265 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJB2 gap junction protein beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr13:1,514,714...1,520,239
Ensembl chr13:19,831,274...19,831,954 		JBrowse link
G GJB6 gap junction protein beta 6 enables IEA Ensembl GO_REF:0000107 NCBI chr13:1,549,089...1,559,452
Ensembl chr13:19,864,939...19,865,724 		JBrowse link
G GJC2 gap junction protein gamma 2 enables ISO (PMID:17344063) UniProt PMID:17344063 NCBI chr 1:203,551,556...203,561,702 JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 enables ISO (PMID:29366904) UniProt PMID:29366904 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA3 gap junction protein alpha 3 enables IEA Ensembl GO_REF:0000107 NCBI chr13:1,464,542...1,488,240
Ensembl chr13:19,784,372...19,785,679 		JBrowse link
G GJA5 gap junction protein alpha 5 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G PANX1 pannexin 1 NOT|enables ISO PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr11:89,142,686...89,295,972
Ensembl chr11:92,628,760...92,685,109 		JBrowse link
G PANX3 pannexin 3 enables IEA Ensembl GO_REF:0000107 NCBI chr11:119,438,866...119,452,174
Ensembl chr11:123,354,919...123,363,463 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:33,146,998...33,154,755
Ensembl chr 6:34,255,769...34,263,211 		JBrowse link
G LOC100982601 voltage-dependent anion-selective channel protein 1 enables IEA UniProt GO_REF:0000043 NCBI chr 3:14,137,389...14,139,209 JBrowse link
G VDAC1 voltage dependent anion channel 1 enables IEA UniProt GO_REF:0000043 NCBI chr 5:129,375,267...129,408,230
Ensembl chr 5:135,529,173...135,560,005 		JBrowse link
G VDAC2 voltage dependent anion channel 2 enables IEA UniProt GO_REF:0000043 NCBI chr10:71,739,395...71,763,835 JBrowse link
G VDAC2 voltage dependent anion channel 2 enables IEA UniProt GO_REF:0000043 Ensembl chr10:74,403,611...74,426,423 JBrowse link
G VDAC3 voltage dependent anion channel 3 enables IEA UniProt GO_REF:0000043 NCBI chr 8:41,638,522...41,652,637
Ensembl chr 8:39,082,698...39,097,437 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17686
    transporter activity 1156
      transmembrane transporter activity 1064
        passive transmembrane transporter activity 495
          channel activity 495
            wide pore channel activity 37
              gap junction channel activity + 24
              gap junction hemi-channel activity 5
              porin activity + 6
paths to the root