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ONTOLOGY REPORT - ANNOTATIONS

Term:hypothalamus development
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Accession:GO:0021854 term browser browse the term
Definition:The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.


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hypothalamus development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO
IEA 		MGI:1857429 (PMID:15342910)
GO_REF:0000107 		RGD
Ensembl		 PMID:15342910 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 acts_upstream_of_or_within ISO
IEA 		MGI:1856982 (PMID:30498428)
GO_REF:0000107 		RGD
Ensembl		 PMID:30498428 GO_REF:0000107 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308 		JBrowse link
G Crh corticotropin releasing hormone IEP RGD PMID:20002962 RGD:5130950 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IEP RGD PMID:20002962 RGD:5130950 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IEP RGD PMID:20002962 RGD:5130950 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in IEA
ISO 		GO_REF:0000107
MGI:1858008 (PMID:32868762) 		Ensembl
RGD		 PMID:32868762 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP RGD PMID:15804399 RGD:4891928 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Esr2 estrogen receptor 2 IEP RGD PMID:12960049 RGD:1582276 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor IEP RGD PMID:8946059 RGD:2313681 NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Gsx1 GS homeobox 1 acts_upstream_of_or_within ISO
IEA 		MGI:2154448 (PMID:8631293)
GO_REF:0000107 		RGD
Ensembl		 PMID:8631293 GO_REF:0000107 NCBI chr12:7,880,663...7,882,947
Ensembl chr12:7,881,460...7,882,753 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEP RGD PMID:23291449 RGD:7207858 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 IEP RGD PMID:12551846 RGD:5688241 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in IEA
ISO 		GO_REF:0000107
MGI:5302534 (PMID:32868762) 		Ensembl
RGD		 PMID:32868762 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Nkx2-6 NK2 homeobox 6 involved_in ISO (PMID:9621431) RGD PMID:9621431 NCBI chr15:44,443,151...44,447,248
Ensembl chr15:44,443,101...44,447,247 		JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 involved_in ISO
IEA 		(PMID:20512159)
GO_REF:0000107 		RGD
Ensembl		 PMID:20512159 GO_REF:0000107 NCBI chr13:41,908,179...41,981,611
Ensembl chr13:39,352,247...39,429,169 		JBrowse link
G Rax retina and anterior neural fold homeobox acts_upstream_of_or_within ISO
IEA 		MGI:1856862 (PMID:925203)
GO_REF:0000107 		RGD
Ensembl		 PMID:925203 GO_REF:0000107 NCBI chr18:59,463,347...59,467,469
Ensembl chr18:59,463,737...59,467,431 		JBrowse link
G Reln reelin IEP RGD PMID:10436054 RGD:634730 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Sox3 SRY-box transcription factor 3 involved_in ISO (PMID:14981518) RGD PMID:14981518 NCBI chr  X:139,308,608...139,310,687
Ensembl chr  X:139,309,329...139,310,678 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 IEP RGD PMID:15804399 PMID:8770891 RGD:4891928, RGD:4892048 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 IEP RGD PMID:15804399 RGD:4891928 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII involved_in ISO
IEA 		(PMID:16901643)
GO_REF:0000107 		RGD
Ensembl		 PMID:16901643 GO_REF:0000107 NCBI chr10:38,086,691...38,093,871
Ensembl chr10:37,586,888...37,589,169 		JBrowse link
gonadotrophin-releasing hormone neuronal migration to the hypothalamus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ndnf neuron-derived neurotrophic factor involved_in ISO (PMID:31883645) RGD PMID:31883645 NCBI chr 4:94,944,392...94,981,871
Ensembl chr 4:94,944,360...94,981,873 		JBrowse link
G Nrp1 neuropilin 1 involved_in ISO
IEA 		(PMID:21059704)
GO_REF:0000107 		RGD
Ensembl		 PMID:21059704 GO_REF:0000107 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21059704) 		Ensembl
RGD		 PMID:21059704 GO_REF:0000107 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Plxna1 plexin A1 involved_in ISO
IEA 		UniProtKB:P70208 (PMID:31690636)
GO_REF:0000107 		RGD
Ensembl		 PMID:31690636 GO_REF:0000107 NCBI chr 4:121,737,934...121,782,901
Ensembl chr 4:121,737,945...122,024,196 		JBrowse link
G Plxna3 plexin A3 involved_in ISO
IEA 		UniProtKB:P70206 (PMID:31690636)
GO_REF:0000107 		RGD
Ensembl		 PMID:31690636 GO_REF:0000107 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603 		JBrowse link
G Sema3a semaphorin 3A involved_in ISO (PMID:21059704) RGD PMID:21059704 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432 		JBrowse link
G Sema3e semaphorin 3E involved_in ISO
IEA 		(PMID:25985275)
GO_REF:0000107 		RGD
Ensembl		 PMID:25985275 GO_REF:0000107 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229 		JBrowse link
hypothalamus cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hap1 huntingtin-associated protein 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24355921) 		Ensembl
RGD		 PMID:24355921 GO_REF:0000107 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Otp orthopedia homeobox acts_upstream_of_or_within ISO
IEA 		MGI:2180541 (PMID:10557207)
GO_REF:0000107 		RGD
Ensembl		 PMID:10557207 GO_REF:0000107 NCBI chr 2:26,108,158...26,116,359
Ensembl chr 2:26,108,163...26,116,359 		JBrowse link
G Pou3f2 POU class 3 homeobox 2 acts_upstream_of_or_within ISO
IEA 		MGI:1857996 (PMID:8543156)
GO_REF:0000107 		RGD
Ensembl		 PMID:8543156 GO_REF:0000107 NCBI chr 5:36,077,930...36,083,838
Ensembl chr 5:36,077,930...36,083,838 		JBrowse link
G Prdm13 PR/SET domain 13 involved_in ISO (PMID:34730112) RGD PMID:34730112 NCBI chr 5:35,220,815...35,232,866
Ensembl chr 5:35,225,435...35,232,881 		JBrowse link
G Prop1 PROP paired-like homeobox 1 acts_upstream_of_or_within ISO
IEA 		MGI:1856842 (PMID:9067988)
GO_REF:0000107 		RGD
Ensembl		 PMID:9067988 GO_REF:0000107 NCBI chr10:35,271,959...35,274,434
Ensembl chr10:35,271,973...35,274,434 		JBrowse link
hypothalamus cell migration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxb1 forkhead box B1 involved_in ISO (PMID:19046377) RGD PMID:19046377 NCBI chr 8:70,407,221...70,409,841
Ensembl chr 8:70,408,186...70,409,781 		JBrowse link
G Pitx2 paired-like homeodomain 2 acts_upstream_of_or_within ISO MGI:1857846 (PMID:18206388) RGD PMID:18206388 NCBI chr 2:220,391,417...220,411,588
Ensembl chr 2:217,717,693...217,737,293 		JBrowse link
hypothalamus gonadotrophin-releasing hormone neuron development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nhlh2 nescient helix loop helix 2 acts_upstream_of_or_within_positive_effect ISO
IEA 		(PMID:23785158)
GO_REF:0000107 		RGD
Ensembl		 PMID:23785158 GO_REF:0000107 NCBI chr 2:189,444,287...189,449,625
Ensembl chr 2:189,442,711...189,449,625 		JBrowse link
G Ubb ubiquitin B acts_upstream_of_or_within ISO
IEA 		MGI:3774112 (PMID:18299572)
GO_REF:0000107 		RGD
Ensembl		 PMID:18299572 GO_REF:0000107 NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,245,637...47,249,333 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure development 6656
        hypothalamus development 37
          hypothalamus cell differentiation + 14
          hypothalamus cell migration + 9
Path 2
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure development 6656
        multicellular organism development 5362
          system development 4644
            nervous system development 2881
              central nervous system development 1238
                brain development 912
                  forebrain development 564
                    diencephalon development 104
                      hypothalamus development 37
                        hypothalamus cell differentiation + 14
                        hypothalamus cell migration + 9
paths to the root