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ONTOLOGY REPORT - ANNOTATIONS

Term:triglyceride biosynthetic process
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Accession:GO:0019432 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
Synonyms:exact_synonym: triacylglycerol biosynthesis;   triacylglycerol biosynthetic process;   triglyceride anabolism;   triglyceride biosynthesis;   triglyceride formation;   triglyceride synthesis
 xref: MetaCyc:TRIGLSYN-PWY;   Reactome:R-HSA-75109 "Triglyceride biosynthesis"


show annotations for term's descendants           Sort by:
triglyceride biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long-chain family member 1 IGI RGD PMID:16466685 RGD:2312800 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 IGI RGD PMID:16466685 RGD:2312800 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 IGI RGD PMID:16466685 RGD:2312800 NCBI chr10:38,940,668...38,999,515
Ensembl chr10:38,940,747...39,002,873 		JBrowse link
G Agmo alkylglycerol monooxygenase involved_in IEA
ISO 		GO_REF:0000107
(PMID:35537527) 		Ensembl
RGD		 PMID:35537527 GO_REF:0000107 NCBI chr 6:59,713,495...60,044,851
Ensembl chr 6:59,713,467...60,044,854 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 involved_in IEA
ISO 		GO_REF:0000107
MGI:1915643 (PMID:16495223), (PMID:19187773) 		Ensembl
RGD		 PMID:16495223 PMID:19187773 GO_REF:0000107 NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:29,814,924...29,826,581 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 involved_in
acts_upstream_of_or_within 		IDA
ISO
IBA
IEA 		(PMID:10802663), (PMID:14668353)
(PMID:11481335)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
(PMID:18458083)
(PMID:18238778), (PMID:32433610), (PMID:32433611) 		RGD
GO_Central
Ensembl
InterPro		 PMID:10802663 PMID:11481335 PMID:14668353 PMID:18238778 PMID:18458083 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:1625586 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA
ISS 		(PMID:11481335), (PMID:27184406)
MGI:3037903 (PMID:11481335), (PMID:12077311), (PMID:14668353)
(PMID:21680734)
(PMID:23066022)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000041
GO_REF:0000024 		RGD
Ensembl
GO_Central
UniProt		 PMID:11481335 PMID:12077311 PMID:14668353 PMID:21680734 PMID:23066022 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566 		JBrowse link
G Fabp1 fatty acid binding protein 1 acts_upstream_of_or_within ISO MGI:98254 (PMID:27940000) RGD PMID:27940000 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Fabp2 fatty acid binding protein 2 acts_upstream_of_or_within ISO (PMID:21350192) RGD PMID:21350192 NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686 		JBrowse link
G Gk glycerol kinase involved_in ISO MGI:2429928 (PMID:9302256) RGD PMID:9302256 NCBI chr  X:54,106,708...54,189,940
Ensembl chr  X:54,112,214...54,196,701 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial involved_in IEA
ISO
IBA 		GO_REF:0000107
MGI:2669956 (PMID:12417724), (PMID:23908354)
GO_REF:0000033
(PMID:18238778) 		Ensembl
RGD
GO_Central		 PMID:12417724 PMID:18238778 PMID:23908354 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911 		JBrowse link
G Gpat2 glycerol-3-phosphate acyltransferase 2, mitochondrial involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:17689486) 		GO_Central
RGD		 PMID:17689486 GO_REF:0000033 NCBI chr 3:135,099,751...135,110,355
Ensembl chr 3:135,096,752...135,110,353 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 involved_in ISO
IEA
ISS 		(PMID:17170135)
GO_REF:0000107
GO_REF:0000024
GO_REF:0000041 		RGD
Ensembl
UniProt		 PMID:17170135 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr14:9,018,762...9,072,552 JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 NOT|involved_in ISO (PMID:18238778)
(PMID:16436371) 		RGD PMID:16436371 PMID:18238778 NCBI chr16:75,515,935...75,555,431
Ensembl chr16:75,521,640...75,557,847 		JBrowse link
G Kat5 lysine acetyltransferase 5 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:212,325,090...212,332,587 		JBrowse link
G Lpgat1 lysophosphatidylglycerol acyltransferase 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:20018982) 		Ensembl
RGD		 PMID:20018982 GO_REF:0000107 NCBI chr13:105,825,630...105,896,366
Ensembl chr13:105,820,468...105,896,364 		JBrowse link
G Lpin1 lipin 1 involved_in ISO
IEA 		(PMID:29765047)
(PMID:24133206)
GO_REF:0000107 		RGD
Ensembl		 PMID:24133206 PMID:29765047 GO_REF:0000107 NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991 		JBrowse link
G Lpin2 lipin 2 involved_in IBA
ISO
IEA 		GO_REF:0000033
(PMID:19136718)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:19136718 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:118,529,988...118,604,796
Ensembl chr 9:118,529,943...118,604,796 		JBrowse link
G Lpin3 lipin 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:169,953,479...169,978,034
Ensembl chr 3:169,960,522...169,978,031 		JBrowse link
G Lpl lipoprotein lipase IMP RGD PMID:11788374 RGD:70246 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:87,429,427...87,436,977
Ensembl chr 9:87,405,119...87,436,977 		JBrowse link
G Mogat2 monoacylglycerol O-acyltransferase 2 involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
(PMID:14966132)
(PMID:12576479)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:12576479 PMID:14966132 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:162,933,964...162,957,896
Ensembl chr 1:162,933,966...162,957,896 		JBrowse link
G Mogat3 monoacylglycerol O-acyltransferase 3 involved_in ISO
IBA 		(PMID:27184406)
GO_REF:0000033 		RGD
GO_Central		 PMID:27184406 GO_REF:0000033 NCBI chr12:25,305,390...25,307,024
Ensembl chr12:25,305,404...25,307,497 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 involved_in ISO
IEA 		(PMID:15364929), (PMID:22560221)
(PMID:22560221)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:15364929 PMID:22560221 GO_REF:0000107 GO_REF:0000117 NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:117,173,516...117,194,594 		JBrowse link
G Scp2 sterol carrier protein 2 acts_upstream_of_or_within ISO MGI:95479 (PMID:27940000) RGD PMID:27940000 NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043 		JBrowse link
G Sirt1 sirtuin 1 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Tmem68 transmembrane protein 68 involved_in ISO
IEA 		(PMID:37648867)
GO_REF:0000107 		RGD
Ensembl		 PMID:37648867 GO_REF:0000107 NCBI chr 5:21,291,675...21,322,443
Ensembl chr 5:21,291,675...21,322,443 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 6:94,696,699...94,707,751
Ensembl chr 6:94,696,358...94,708,618 		JBrowse link
glycerol biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in
acts_upstream_of_or_within 		IDA
IBA
IEA
ISO 		PMID:4186849
GO_REF:0000033
GO_REF:0000107
MGI:2182390 (PMID:11792850) 		GO_Central
Ensembl
RGD		 PMID:11792850 PMID:4186849 GO_REF:0000033 GO_REF:0000107, RGD:8553288 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864 		JBrowse link
negative regulation of triglyceride biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir30c1 microRNA 30c-1 acts_upstream_of ISO (PMID:23749231) RGD PMID:23749231 NCBI chr 5:139,634,455...139,634,543 JBrowse link
G Mir30c2 microRNA 30c-2 acts_upstream_of ISO (PMID:23749231) RGD PMID:23749231 NCBI chr 9:33,253,682...33,253,765
Ensembl chr 9:33,253,682...33,253,765 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 IMP RGD PMID:29148806 RGD:15042869 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Sik1 salt-inducible kinase 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:19244231)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:19244231 GO_REF:0000024 GO_REF:0000107 NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA 		(PMID:29765047)
GO_REF:0000107 		RGD
Ensembl		 PMID:29765047 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 involved_in ISO
IEA 		(PMID:37648867)
GO_REF:0000107 		RGD
Ensembl		 PMID:37648867 GO_REF:0000107 NCBI chr 6:94,696,699...94,707,751
Ensembl chr 6:94,696,358...94,708,618 		JBrowse link
positive regulation of triglyceride biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl5 acyl-CoA synthetase long-chain family member 5 IDA RGD PMID:16263710 RGD:2312807 NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943 		JBrowse link
G Apoc3 apolipoprotein C3 IMP RGD PMID:23542898 RGD:10054091 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679 		JBrowse link
G Cnep1r1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 involved_in ISO
IEA 		(PMID:22134922)
GO_REF:0000107 		RGD
Ensembl		 PMID:22134922 GO_REF:0000107 NCBI chr19:35,106,802...35,121,101
Ensembl chr19:35,106,802...35,121,101 		JBrowse link
G Ctdnep1 CTD nuclear envelope phosphatase 1 involved_in ISO
IEA
ISS 		(PMID:22134922)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:22134922 GO_REF:0000024 GO_REF:0000107 NCBI chr10:55,203,047...55,212,469
Ensembl chr10:55,203,543...55,212,852 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 IMP RGD PMID:23449193 RGD:10400846 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 IMP RGD PMID:17526931 RGD:10400884 NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial IDA RGD PMID:15598672 RGD:2313665 NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:16219662) 		UniProt
RGD		 PMID:16219662 GO_REF:0000024 NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:29765047) 		UniProt
Ensembl
RGD		 PMID:29765047 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:212,325,090...212,332,587 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO 		GO_REF:0000107
(PMID:18175806) 		Ensembl
RGD		 PMID:18175806 GO_REF:0000107 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:23209793) 		Ensembl
RGD		 PMID:23209793 GO_REF:0000107 NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 acts_upstream_of IEA
ISO 		GO_REF:0000107
(PMID:17186944) 		Ensembl
RGD		 PMID:17186944 GO_REF:0000107 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:104,178,234...104,183,863 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 involved_in ISO
IEA 		(PMID:17693624)
GO_REF:0000107 		RGD
Ensembl		 PMID:17693624 GO_REF:0000107 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Plin5 perilipin 5 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:17130488), (PMID:21885430), (PMID:22532565)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:17130488 PMID:21885430 PMID:22532565 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:1,026,910...1,033,352
Ensembl chr 9:1,026,307...1,033,284 		JBrowse link
G Rgn regucalcin IDA RGD PMID:16817230 RGD:9590221 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:4,172,537...4,190,251 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:18175806) 		Ensembl
RGD		 PMID:18175806 GO_REF:0000107 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:12235169)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:12235169 GO_REF:0000024 GO_REF:0000107 NCBI chr16:18,311,859...18,337,024
Ensembl chr16:18,313,015...18,330,045 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within 		ISS
ISO
IEA 		GO_REF:0000024
MGI:2177959 (PMID:16046411)
(PMID:19244231)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:16046411 PMID:19244231 GO_REF:0000024 GO_REF:0000107 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 acts_upstream_of_or_within ISO MGI:1926344 (PMID:23260145) RGD PMID:23260145 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
regulation of triglyceride biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:10432298) 		Ensembl
UniProt
RGD		 PMID:10432298 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Thrsp thyroid hormone responsive involved_in IEA
ISO 		GO_REF:0000107
(PMID:15890771) 		Ensembl
RGD		 PMID:15890771 GO_REF:0000107 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        biosynthetic process 8271
          lipid biosynthetic process 748
            neutral lipid biosynthetic process 60
              acylglycerol biosynthetic process 60
                triglyceride biosynthetic process 51
                  glycerol biosynthetic process from pyruvate 2
                  negative regulation of triglyceride biosynthetic process 6
                  positive regulation of triglyceride biosynthetic process 19
                  regulation of triglyceride biosynthetic process + 27
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        primary metabolic process 10162
          lipid metabolic process 1489
            neutral lipid metabolic process 163
              acylglycerol metabolic process 161
                triglyceride metabolic process 132
                  triglyceride biosynthetic process 51
                    glycerol biosynthetic process from pyruvate 2
                    negative regulation of triglyceride biosynthetic process 6
                    positive regulation of triglyceride biosynthetic process 19
                    regulation of triglyceride biosynthetic process + 27
paths to the root