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ONTOLOGY REPORT - ANNOTATIONS

Term:NMDA selective glutamate receptor complex
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Accession:GO:0017146 term browser browse the term
Definition:An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD.
Synonyms:exact_synonym: N-methyl-D-aspartate selective glutamate receptor complex;   NMDA-selective glutamate receptor


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NMDA selective glutamate receptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eps8 EGFR pathway substrate 8, signaling adaptor part_of IEA
ISO		 GO_REF:0000107
(PMID:17018287)		 Ensembl
RGD		 PMID:17018287 GO_REF:0000107 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 part_of TAS
IDA
IEA
IBA
ISS
IPI
ISO		 PMID:24876489
PMID:28384476
PMID:18177891
GO_REF:0000117
GO_REF:0000033
GO_REF:0000114
PMID:24462099
PR:P35436|PR:Q01097 (PMID:9003035)
PMID:36959261
(PMID:10480938), (PMID:17047094), (PMID:26875626), (PMID:26919761), (PMID:28105280), (PMID:28126851), (PMID:34321660), (PMID:36309015), (PMID:36959261), (PMID:7679115)		 UniProt
GO_Central
ComplexPortal
RGD		 PMID:7679115 PMID:9003035 PMID:10480938 PMID:17047094 PMID:26875626 More... GO_REF:0000033 GO_REF:0000114 GO_REF:0000117, RGD:727495, RGD:1642190, RGD:1642380, RGD:7241301, RGD:13432263, RGD:13432313, RGD:13432252, RGD:150521652, RGD:13432263, RGD:408345213 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A part_of IDA
IEA
ISO
ISS
IPI
IBA		 PMID:23625947
PMID:8702950
PMID:28384476
GO_REF:0000107
PR:P35438|UniProtKB:P35439 (PMID:7929101), (PMID:9003035)
GO_REF:0000114
PMID:24462099
(PMID:10480938), (PMID:26875626), (PMID:28095420)
GO_REF:0000033		 Ensembl
RGD
ComplexPortal
GO_Central		 PMID:7929101 PMID:9003035 PMID:10480938 PMID:26875626 PMID:28095420 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:1642190, RGD:7241301, RGD:13432339, RGD:8553561, RGD:13432313, RGD:150521652 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B part_of IDA
IEA
ISO
IPI
ISS
IBA		 PMID:28384476
PMID:8702950
PMID:24876489
GO_REF:0000107
PR:P35438 (PMID:9003035)
GO_REF:0000114
GO_REF:0000033
(PMID:10480938), (PMID:17047094), (PMID:26875626), (PMID:26919761), (PMID:34321660)		 Ensembl
RGD
ComplexPortal
GO_Central		 PMID:9003035 PMID:10480938 PMID:17047094 PMID:26875626 PMID:26919761 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:727540, RGD:1642190, RGD:13432313, RGD:8553561, RGD:13432263, RGD:13432263 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C part_of IEA
ISO
IDA
IBA
IPI		 GO_REF:0000107
UniProtKB:P35439 (PMID:7929101)
(PMID:26875626), (PMID:26919761), (PMID:36309015), (PMID:36959261)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:7929101 PMID:26875626 PMID:26919761 PMID:36309015 PMID:36959261 More... GO_REF:0000033 GO_REF:0000107, RGD:408345213, RGD:408345213 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D part_of IDA
ISS
IBA
ISO		 PMID:23625947
GO_REF:0000114
GO_REF:0000033
(PMID:26875626), (PMID:26919761), (PMID:36309015)		 ComplexPortal
GO_Central
RGD		 PMID:26875626 PMID:26919761 PMID:36309015 PMID:17050728 PMID:23625947 GO_REF:0000033 GO_REF:0000114, RGD:1642380, RGD:13432339 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A part_of IDA
ISO
IEA		 (PMID:17997397)
PMID:17182766
GO_REF:0000107		 RGD
Ensembl		 PMID:17997397 PMID:16477151 PMID:17182766 GO_REF:0000107, RGD:1642190, RGD:8553928 NCBI chr 5:64,006,847...64,206,408
Ensembl chr 5:64,009,980...64,206,085 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B part_of IDA
IEA
ISO		 GO_REF:0000107
(PMID:14602821)		 Ensembl
RGD		 PMID:14602821 PMID:11823786 GO_REF:0000107, RGD:632842 NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta part_of
is_active_in		 IMP
IDA		 PMID:15814199
PMID:11239437		 Alzheimers_University_of_Toronto PMID:15814199 PMID:11239437 PMID:15814199 RGD:8655534, RGD:8553497, RGD:8655534 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21321
    protein-containing complex 6790
      receptor complex 492
        plasma membrane signaling receptor complex 271
          neurotransmitter receptor complex 51
            ionotropic glutamate receptor complex 46
              NMDA selective glutamate receptor complex 9
Path 2
Term Annotations click to browse term
  cellular_component 21321
    cellular anatomical structure 21026
      membrane 10474
        membrane protein complex 1432
          plasma membrane protein complex 683
            plasma membrane signaling receptor complex 271
              neurotransmitter receptor complex 51
                ionotropic glutamate receptor complex 46
                  NMDA selective glutamate receptor complex 9
paths to the root