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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidative phosphorylation uncoupler activity
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Accession:GO:0017077 term browser browse the term
Definition:Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms:narrow_synonym: mitochondrial uncoupling protein activity;   uncoupling protein activity
 alt_id: GO:0015302


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oxidative phosphorylation uncoupler activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC25A4 solute carrier family 25 member 4 enables IEA Ensembl GO_REF:0000107 NCBI chr15:46,193,498...46,197,989
Ensembl chr15:46,193,746...46,200,987 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 enables IEA Ensembl GO_REF:0000107 NCBI chr  X:97,919,295...97,922,245
Ensembl chr  X:97,919,290...97,922,239 		JBrowse link
G UCP1 uncoupling protein 1 enables ISO PMID:22952235
(PMID:12910269), (PMID:23063128)
(PMID:20416274)		 RGD
UniProt		 PMID:12910269 PMID:16451125 PMID:20416274 PMID:22952235 PMID:23063128 RGD:11541104 RGD:1624981 NCBI chr 8:86,522,028...86,526,162 JBrowse link
G UCP2 uncoupling protein 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 9:8,358,559...8,364,552
Ensembl chr 9:8,358,025...8,365,547 		JBrowse link
G UCP3 uncoupling protein 3 NOT|enables ISO
IEA
IBA		 (PMID:11707458)
(PMID:11707458), (PMID:20363757)		 UniProt
Ensembl
GO_Central		 PMID:11707458 PMID:20363757 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:8,378,023...8,389,452
Ensembl chr 9:8,378,021...8,386,211 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18634
    transporter activity 1193
      transmembrane transporter activity 1096
        oxidative phosphorylation uncoupler activity 5
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