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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidative phosphorylation uncoupler activity
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Accession:GO:0017077 term browser browse the term
Definition:Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms:narrow_synonym: mitochondrial uncoupling protein activity;   uncoupling protein activity
 alt_id: GO:0015302


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oxidative phosphorylation uncoupler activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 enables IDA (PMID:31341297) UniProt PMID:31341297 NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321 		JBrowse link
G Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 enables IDA (PMID:31341297) UniProt PMID:31341297 NCBI chr  X:36,059,250...36,062,461
Ensembl chr  X:36,059,304...36,062,460 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) enables ISO
IDA
IMP
IBA		 (PMID:12910269), (PMID:23063128)
(PMID:20416274)		 RGD
UniProt
GO_Central		 PMID:12910269 PMID:16451125 PMID:20416274 PMID:23063128 GO_REF:0000033 GO_REF:0000096 RGD:1624981 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) enables IBA GO_Central GO_REF:0000033 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) enables
NOT|enables		 IMP
ISO		 (PMID:10748196)
(PMID:10748195)
(PMID:11707458), (PMID:20363757)		 MGI
GO_Central
UniProt		 PMID:10748195 PMID:10748196 PMID:11707458 PMID:20363757 GO_REF:0000119 NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28792
    transporter activity 1221
      transmembrane transporter activity 1121
        oxidative phosphorylation uncoupler activity 5
paths to the root