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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidative phosphorylation uncoupler activity
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Accession:GO:0017077 term browser browse the term
Definition:Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms:narrow_synonym: mitochondrial uncoupling protein activity;   uncoupling protein activity
 alt_id: GO:0015302


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oxidative phosphorylation uncoupler activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC25A4 solute carrier family 25 member 4 enables ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:185,143,266...185,150,382
Ensembl chr 4:185,143,266...185,150,382 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 enables ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:119,468,444...119,471,396
Ensembl chr  X:119,468,422...119,471,396 		JBrowse link
G UCP1 uncoupling protein 1 enables ISO
IEA
ISS
IBA		 RGD
Ensembl
UniProt
GO_Central		 PMID:16451125 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 RGD:1624981 NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961 		JBrowse link
G UCP2 uncoupling protein 2 enables IBA GO_Central GO_REF:0000033 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,061...73,982,843 		JBrowse link
G UCP3 uncoupling protein 3 enables
NOT|enables		 IEA
IBA
IDA
IMP
TAS		 (PMID:11707458)
(PMID:21775425)
(PMID:36114012), (PMID:9305858)
(PMID:9196039)		 Ensembl
GO_Central
UniProt
PINC		 PMID:9196039 PMID:9305858 PMID:11707458 PMID:21775425 PMID:36114012 GO_REF:0000033 GO_REF:0000107 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19524
    transporter activity 1302
      transmembrane transporter activity 1183
        oxidative phosphorylation uncoupler activity 5
paths to the root