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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidative phosphorylation uncoupler activity
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Accession:GO:0017077 term browser browse the term
Definition:Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms:narrow_synonym: mitochondrial uncoupling protein activity;   uncoupling protein activity
 alt_id: GO:0015302

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oxidative phosphorylation uncoupler activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103247334 ADP/ATP translocase 2 enables ISO (PMID:31341297) UniProt PMID:31341297
G SLC25A4 solute carrier family 25 member 4 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:131,102,077...131,106,076 JBrowse link
G UCP1 uncoupling protein 1 enables ISO
IEA		 RGD
Ensembl
UniProt		 PMID:16451125 GO_REF:0000104 GO_REF:0000107 RGD:1624981 NCBI chr 7:87,492,444...87,502,894
Ensembl chr 7:87,492,195...87,502,665 		JBrowse link
G UCP3 uncoupling protein 3 enables
NOT|enables		 IEA
ISO		 (PMID:11707458)
(PMID:11707458), (PMID:20363757)		 Ensembl
UniProt		 PMID:11707458 PMID:20363757 GO_REF:0000107 NCBI chr 1:65,269,611...65,279,079
Ensembl chr 1:65,269,607...65,278,807 		JBrowse link
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Term Annotations click to browse term
  molecular_function 18124
    transporter activity 1196
      transmembrane transporter activity 1103
        oxidative phosphorylation uncoupler activity 4
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