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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidative phosphorylation uncoupler activity
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Accession:GO:0017077 term browser browse the term
Definition:Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Synonyms:narrow_synonym: mitochondrial uncoupling protein activity;   uncoupling protein activity
 alt_id: GO:0015302


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oxidative phosphorylation uncoupler activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC25A4 solute carrier family 25 member 4 enables IEA Ensembl GO_REF:0000107 NCBI chr16:45,454,660...45,458,606
Ensembl chr16:45,411,810...45,542,162 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 enables ISO (PMID:31341297) UniProt PMID:31341297 NCBI chr  X:91,523,649...91,526,447
Ensembl chr  X:91,523,643...91,526,479 		JBrowse link
G UCP1 uncoupling protein 1 enables ISO
IEA
ISS
IBA		 RGD
UniProt
GO_Central		 PMID:16451125 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 RGD:1624981 NCBI chr19:2,254,881...2,289,902 JBrowse link
G UCP2 uncoupling protein 2 enables IBA GO_Central GO_REF:0000033 NCBI chr21:24,304,410...24,311,392
Ensembl chr21:24,304,457...24,311,128 		JBrowse link
G UCP3 uncoupling protein 3 enables
NOT|enables		 IEA
ISO
IBA		 (PMID:11707458)
(PMID:11707458), (PMID:20363757)		 Ensembl
UniProt
GO_Central		 PMID:11707458 PMID:20363757 GO_REF:0000033 GO_REF:0000107 NCBI chr21:24,272,522...24,290,304
Ensembl chr21:24,277,896...24,288,639 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18607
    transporter activity 1198
      transmembrane transporter activity 1105
        oxidative phosphorylation uncoupler activity 5
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