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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic recombination of immunoglobulin gene segments
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Accession:GO:0016447 term browser browse the term
Definition:The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.
Synonyms:exact_synonym: somatic recombination of antibody gene segments


show annotations for term's descendants           Sort by:
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO
IEA		 MGI:1857946 (PMID:11828012)
GO_REF:0000107		 RGD
Ensembl		 PMID:11828012 GO_REF:0000107 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within ISO
IEA		 MGI:109352|MGI:1857940|MGI:2151801|MGI:2680817 (PMID:11828012), (PMID:14563316), (PMID:14568978), (PMID:15494304), (PMID:15955838)
GO_REF:0000107		 RGD
Ensembl		 PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 GO_REF:0000107 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 acts_upstream_of_or_within ISO MGI:1858056 (PMID:15238604) RGD PMID:15238604 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO
IEA		 MGI:1858014 (PMID:15238604)
GO_REF:0000107		 RGD
Ensembl		 PMID:15238604 GO_REF:0000107 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component acts_upstream_of_or_within ISO
IEA		 MGI:1857947 (PMID:11828012)
GO_REF:0000107		 RGD
Ensembl		 PMID:11828012 GO_REF:0000107 NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:101816|MGI:2182610 (PMID:15494304) RGD PMID:15494304 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polb DNA polymerase beta acts_upstream_of_or_within ISO
IEA		 MGI:5427084 (PMID:24388753)
GO_REF:0000107		 RGD
Ensembl		 PMID:24388753 GO_REF:0000107 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Yy1 YY1 transcription factor involved_in ISO
IEA		 MGI:3624790 (PMID:23531880)
GO_REF:0000107		 RGD
Ensembl		 PMID:23531880 GO_REF:0000107 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyren cell cycle regulator of NHEJ involved_in ISS
ISO		 GO_REF:0000024
(PMID:30017584), (PMID:31795137)		 UniProt
RGD		 PMID:30017584 PMID:31795137 GO_REF:0000024 NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602 		JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:3711150 (PMID:16819554) RGD PMID:16819554 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Lig4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1857732 (PMID:9823897)		 GO_Central
RGD		 PMID:9823897 GO_REF:0000033 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 involved_in ISO
IEA
ISS		 (PMID:20558749)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20558749 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
MGI:2383951 (PMID:9768755)		 GO_Central
Ensembl
RGD		 PMID:9768755 GO_REF:0000033 GO_REF:0000107 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:16428437)
GO_REF:0000107
MGI:2178112 (PMID:16428437)
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:16428437 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1926771 (PMID:9875844)		 GO_Central
RGD		 PMID:9875844 GO_REF:0000033 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase acts_upstream_of_or_within
involved_in		 ISO (PMID:17713479)
(PMID:21518874)		 RGD PMID:17713479 PMID:21518874 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of ISO
IEA		 MGI:4127920 (PMID:25404367)
GO_REF:0000107		 RGD
Ensembl		 PMID:25404367 GO_REF:0000107 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:20421391), (PMID:21572431)		 UniProt
Ensembl
RGD		 PMID:20421391 PMID:21572431 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Cd40lg CD40 ligand involved_in IEA
ISO		 GO_REF:0000107
(PMID:7529792)		 Ensembl
RGD		 PMID:7529792 GO_REF:0000107 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO MGI:2183944 (PMID:15280420) RGD PMID:15280420 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO
IEA		 MGI:2653925 (PMID:14716311)
GO_REF:0000107		 RGD
Ensembl		 PMID:14716311 GO_REF:0000107 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Exosc3 exosome component 3 involved_in ISO
IEA		 (PMID:21255825)
GO_REF:0000107		 RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc6 exosome component 6 involved_in ISO
IEA		 (PMID:21255825)
GO_REF:0000107		 RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (PMID:17713479) RGD PMID:17713479 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO
IEA		 MGI:1857946 (PMID:12743174)
GO_REF:0000107		 RGD
Ensembl		 PMID:12743174 GO_REF:0000107 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within ISO
IEA		 MGI:1857940|MGI:2151801 (PMID:10430621), (PMID:12743174)
GO_REF:0000107		 RGD
Ensembl		 PMID:10430621 PMID:12743174 GO_REF:0000107 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO
IEA		 MGI:109352|MGI:3653701 (PMID:16618598), (PMID:17015724)
GO_REF:0000107		 RGD
Ensembl		 PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Nbn nibrin involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:15668383)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15668383 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930|MGI:5501251 (PMID:25124037), (PMID:31182790) RGD PMID:25124037 PMID:31182790 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19139091)		 UniProt
Ensembl
RGD		 PMID:19139091 GO_REF:0000024 GO_REF:0000107 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357 		JBrowse link
G Rnf168 ring finger protein 168 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20080757)		 UniProt
RGD		 PMID:20080757 GO_REF:0000024 NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277 		JBrowse link
G Rnf8 ring finger protein 8 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20080757)		 UniProt
RGD		 PMID:20080757 GO_REF:0000024 NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491 		JBrowse link
G Sanbr SANT and BTB domain regulator of CSR involved_in ISS
IBA
ISO
IEA		 GO_REF:0000024
GO_REF:0000033
(PMID:33831416)
GO_REF:0000107		 UniProt
GO_Central
RGD
Ensembl		 PMID:33831416 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr14:97,516,652...97,585,955
Ensembl chr14:97,516,413...97,581,346 		JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 acts_upstream_of_or_within ISO
IEA		 (PMID:9642267)
GO_REF:0000107		 RGD
Ensembl		 PMID:9642267 GO_REF:0000107 NCBI chr 1:164,267,588...164,328,796
Ensembl chr 1:164,267,609...164,328,794 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:1343961 (PMID:17015724) RGD PMID:17015724 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771|MGI:3047571|MGI:3641440 (PMID:17713479) RGD PMID:17713479 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO
IEA		 (PMID:27174992)
GO_REF:0000107		 RGD
Ensembl		 PMID:27174992 GO_REF:0000107 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
isotype switching to IgD isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_positive_effect ISO MGI:7719862 (PMID:17548624) RGD PMID:17548624 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO
IEA		 MGI:103034|MGI:2158438 (PMID:10490661)
GO_REF:0000107		 RGD
Ensembl		 PMID:10490661 GO_REF:0000107 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO MGI:7719862 (PMID:17548624) RGD PMID:17548624 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO
IEA		 MGI:3696705 (PMID:16275384)
GO_REF:0000107		 RGD
Ensembl		 PMID:16275384 GO_REF:0000107 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of ISO MGI:107187 (PMID:10490661) RGD PMID:10490661 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO MGI:7719862 (PMID:17548624) RGD PMID:17548624 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) RGD PMID:16148103 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO
IEA		 (PMID:26000965)
GO_REF:0000107		 RGD
Ensembl		 PMID:26000965 GO_REF:0000107 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein involved_in ISO MGI:6723808|MGI:7719862 (PMID:24399151) RGD PMID:24399151 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO
IEA		 MGI:103034|MGI:2158438 (PMID:10490661)
GO_REF:0000107		 RGD
Ensembl		 PMID:10490661 GO_REF:0000107 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO
IEA		 MGI:3696705 (PMID:16275384)
GO_REF:0000107		 RGD
Ensembl		 PMID:16275384 GO_REF:0000107 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO
IEA		 MGI:3695433 (PMID:17137798)
GO_REF:0000107		 RGD
Ensembl		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO
IEA		 (PMID:12496423)
GO_REF:0000107		 RGD
Ensembl		 PMID:12496423 GO_REF:0000107 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within ISO
IEA		 (PMID:21255825)
GO_REF:0000107		 RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within ISO
IEA		 (PMID:21255825)
GO_REF:0000107		 RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:31806351)		 UniProt
Ensembl
RGD		 PMID:31806351 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28114273)		 UniProt
Ensembl
RGD		 PMID:28114273 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28114273)		 UniProt
Ensembl
RGD		 PMID:28114273 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:20671152) RGD PMID:20671152 NCBI chr 4:7,525,132...7,576,659
Ensembl chr 4:7,525,004...7,576,548 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO
IEA		 (PMID:23306439), (PMID:23333305), (PMID:23333306)
GO_REF:0000107		 RGD
Ensembl		 PMID:23306439 PMID:23333305 PMID:23333306 GO_REF:0000107 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA		 (PMID:29656893)
GO_REF:0000033		 RGD
GO_Central		 PMID:29656893 GO_REF:0000033 NCBI chr 3:119,938,695...120,011,068
Ensembl chr 3:119,938,833...120,009,550 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965 		JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO
IEA
IBA		 (PMID:29656893)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:29656893 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:35,297,255...35,302,071
Ensembl chr 2:35,295,859...35,302,346 		JBrowse link
G Tfrc transferrin receptor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:26642240)		 UniProt
Ensembl
RGD		 PMID:26642240 GO_REF:0000024 GO_REF:0000107 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO
IEA		 (PMID:23345425), (PMID:23760478)
GO_REF:0000107
(PMID:15077110), (PMID:15159415)		 RGD
Ensembl		 PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 GO_REF:0000107 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO
IEA		 (PMID:23241889)
GO_REF:0000107		 RGD
Ensembl		 PMID:23241889 GO_REF:0000107 NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO
IEA		 UniProtKB:Q9JK91 (PMID:10430621)
GO_REF:0000107		 RGD
Ensembl		 PMID:10430621 GO_REF:0000107 NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:14988498)		 AgBase
Ensembl
RGD		 PMID:14988498 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnfsf13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:14988498)
MGI:3038886 (PMID:14988498)
GO_REF:0000033		 RGD
GO_Central		 PMID:14988498 GO_REF:0000033 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in ISO (PMID:12023368) RGD PMID:12023368 NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:201,507,859...201,517,605 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (PMID:10490661) RGD PMID:10490661 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO
IEA		 MGI:4127920 (PMID:25404367)
GO_REF:0000107		 RGD
Ensembl		 PMID:25404367 GO_REF:0000107 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (PMID:7688139) RGD PMID:7688139 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd40 CD40 molecule acts_upstream_of_or_within ISO (PMID:12882831) RGD PMID:12882831 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) RGD PMID:12882831 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO MGI:1857191 (PMID:1830926) RGD PMID:1830926 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) RGD PMID:12882831 PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 involved_in ISO (PMID:26744420) RGD PMID:26744420 NCBI chr 1:181,622,698...181,625,024 JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:26744420) RGD PMID:26744420 NCBI chr 4:7,525,132...7,576,659
Ensembl chr 4:7,525,004...7,576,548 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO
IEA		 UniProtKB:Q9JK91 (PMID:10430621)
GO_REF:0000107		 RGD
Ensembl		 PMID:10430621 GO_REF:0000107 NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (PMID:9015183) RGD PMID:9015183 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Tbx21 T-box transcription factor 21 acts_upstream_of_or_within ISO
IEA		 MGI:2180194 (PMID:12882831)
GO_REF:0000107		 RGD
Ensembl		 PMID:12882831 GO_REF:0000107 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor acts_upstream_of_or_within ISO
IEA		 MGI:4128102 (PMID:21211721)
GO_REF:0000107		 RGD
Ensembl		 PMID:21211721 GO_REF:0000107 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Mir181b1 microRNA 181b-1 acts_upstream_of_or_within ISO (PMID:18762567) RGD PMID:18762567 NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797 		JBrowse link
G Mir181b2 microRNA 181b-2 acts_upstream_of_or_within ISO (PMID:18762567) RGD PMID:18762567 NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035 		JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISO
IEA		 (PMID:21518874)
GO_REF:0000107		 RGD
Ensembl		 PMID:21518874 GO_REF:0000107 NCBI chr10:63,103,920...63,140,780
Ensembl chr10:63,103,921...63,140,780 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO
IEA		 MGI:3696705 (PMID:16275384)
GO_REF:0000107		 RGD
Ensembl		 PMID:16275384 GO_REF:0000107 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO
IEA		 MGI:3525439 (PMID:11057672)
GO_REF:0000107		 RGD
Ensembl		 PMID:11057672 GO_REF:0000107 NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO
IEA		 MGI:3695433 (PMID:17137798)
GO_REF:0000107		 RGD
Ensembl		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:25310967)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:25310967 GO_REF:0000024 GO_REF:0000107 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO
IEA		 MGI:101816 (PMID:12743174)
GO_REF:0000107		 RGD
Ensembl		 PMID:12743174 GO_REF:0000107 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
MGI:101938 (PMID:12743174)		 GO_Central
Ensembl
RGD		 PMID:12743174 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      somatic diversification of immune receptors 87
        somatic diversification of immune receptors via germline recombination within a single locus 80
          somatic recombination of immunoglobulin gene segments 68
            B cell receptor editing + 0
            immunoglobulin V(D)J recombination + 9
            somatic diversification of immunoglobulin genes by N region addition 0
            somatic recombination of immunoglobulin genes involved in immune response + 60
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        primary metabolic process 10745
          nucleobase-containing compound metabolic process 5888
            nucleic acid metabolic process 5280
              DNA metabolic process 976
                DNA recombination 340
                  somatic cell DNA recombination 80
                    somatic diversification of immune receptors via germline recombination within a single locus 80
                      somatic recombination of immunoglobulin gene segments 68
                        B cell receptor editing + 0
                        immunoglobulin V(D)J recombination + 9
                        somatic diversification of immunoglobulin genes by N region addition 0
                        somatic recombination of immunoglobulin genes involved in immune response + 60
paths to the root