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ONTOLOGY REPORT - ANNOTATIONS

Term:15-hydroxyprostaglandin dehydrogenase (NAD+) activity
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Accession:GO:0016404 term browser browse the term
Definition:Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+.
Synonyms:related_synonym: (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity;   11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity;   15-OH-PGDH;   15-hydroxyprostaglandin dehydrogenase activity;   15-hydroxyprostanoic dehydrogenase activity;   NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I);   NAD-specific 15-hydroxyprostaglandin dehydrogenase activity;   prostaglandin dehydrogenase activity
 xref: EC:1.1.1.141;   MetaCyc:1.1.1.141-RXN;   RHEA:11876;   reactome:R-HSA-2161662 "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD";   reactome:R-HSA-2161779 "LXA4 is oxidised to 15k-LXA4 by HPGD";   reactome:R-HSA-9023968 "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1";   reactome:R-HSA-9024766 "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1"


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15-hydroxyprostaglandin dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpgd 15-hydroxyprostaglandin dehydrogenase enables IDA
ISO
ISS
IBA		 (PMID:10198228), (PMID:15581601), (PMID:16828555), (PMID:2025296), (PMID:21072165), (PMID:8086429)
GO_REF:0000024
GO_REF:0000033
(PMID:15542609)		 RGD
UniProt
GO_Central		 PMID:2025296 PMID:8086429 PMID:10198228 PMID:15542609 PMID:15581601 More... GO_REF:0000024 GO_REF:0000033, RGD:633016 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
Term paths to the root
Path 1
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  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            15-hydroxyprostaglandin dehydrogenase (NAD+) activity 1
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