Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:protein-arginine N-methyltransferase activity
go back to main search page
Accession:GO:0016274 term browser browse the term
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
Synonyms:exact_synonym: PRMT activity
 xref: reactome:R-HSA-191790 "Loading and methylation of Sm proteins onto SMN Complexes";   reactome:R-HSA-5205798 "PRMT1,PRMT6 methylate arginine-4 of histone H4";   reactome:R-HSA-5205820 "PRMT6 methylates arginine-4 of histone H2A (H2AR3)";   reactome:R-HSA-5205822 "CARM1 methylates arginine-18 (H3R17) of histone H3";   reactome:R-HSA-5205824 "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)";   reactome:R-HSA-5205867 "PRMT1 methylates arginine-12 of histone H2A (H2AR11)";   reactome:R-HSA-5218952 "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)";   reactome:R-HSA-5229010 "CARM1 methylates arginine-27 of histone H3 (H3R26)";   reactome:R-HSA-5229203 "PRMT6 methylates histone H2A arginine-30 (H2AR29)";   reactome:R-HSA-5661126 "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4";   reactome:R-HSA-8879123 "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2";   reactome:R-HSA-8934735 "PRMT1 arginine-methylates RUNX1"



show annotations for term's descendants           Sort by:
protein-arginine N-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables ISS
ISO
IEA
GO_REF:0000024
(PMID:19843527)
GO_REF:0000002
(PMID:18495660)
UniProt
RGD
InterPro
PMID:18495660 PMID:19843527 GO_REF:0000002 GO_REF:0000024 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G ENSRNOG00000066641 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 6:112,302,396...112,303,446 JBrowse link
G Fbxo11 F-box protein 11 enables ISO
IEA
(PMID:16487488)
GO_REF:0000107
RGD
Ensembl
PMID:16487488 GO_REF:0000107 NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662
JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IDA
ISO
IEA
(PMID:21652632)
(PMID:18316480), (PMID:18495660), (PMID:33667543)
GO_REF:0000002
RGD
InterPro
PMID:18316480 PMID:18495660 PMID:21652632 PMID:33667543 PMID:10899106 GO_REF:0000002, RGD:7243104 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt1l1 protein arginine methyltransferase 1 like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:87,551,165...87,552,305
Ensembl chr14:87,551,207...87,552,294
JBrowse link
G Prmt2 protein arginine methyltransferase 2 enables IBA
ISO
GO_REF:0000033
(PMID:20798359)
GO_Central
RGD
PMID:20798359 GO_REF:0000033 NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643
JBrowse link
G Prmt3 protein arginine methyltransferase 3 enables IDA
IBA
ISO
IEA
GO_REF:0000033
(PMID:18495660)
GO_REF:0000107
GO_REF:0000002
GO_Central
RGD
Ensembl
InterPro
PMID:18495660 PMID:9642256 PMID:10899106 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:729523, RGD:7243104 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables ISO (PMID:20421892), (PMID:26554819) RGD PMID:20421892 PMID:26554819 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 enables ISO
IBA
(PMID:30420520)
(PMID:18495660), (PMID:26070566)
GO_REF:0000033
RGD
GO_Central
PMID:18495660 PMID:26070566 PMID:30420520 GO_REF:0000033 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prmt7 protein arginine methyltransferase 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577
JBrowse link
G Prmt9 protein arginine methyltransferase 9 enables ISO
IBA
(PMID:25737013), (PMID:25979344)
GO_REF:0000033
RGD
GO_Central
PMID:25737013 PMID:25979344 GO_REF:0000033 NCBI chr19:30,376,342...30,414,491
Ensembl chr19:30,380,124...30,414,458
JBrowse link
histone arginine N-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables ISO (PMID:23980157) RGD PMID:23980157 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 enables ISO (PMID:23980157) RGD PMID:23980157 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
histone H2AR3 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prmt5 protein arginine methyltransferase 5 enables ISO (PMID:16699504) RGD PMID:16699504 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 enables ISO (PMID:18079182) RGD PMID:18079182 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
histone H3R17 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables ISS
ISO
GO_REF:0000024
(PMID:11341840), (PMID:17882261)
(PMID:15471871)
UniProt
RGD
PMID:11341840 PMID:15471871 PMID:17882261 GO_REF:0000024 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Mettl23 methyltransferase 23, arginine enables ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:28930672)
UniProt
GO_Central
RGD
PMID:28930672 GO_REF:0000024 GO_REF:0000033 NCBI chr10:102,047,090...102,053,379
Ensembl chr10:102,047,314...102,051,977
JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810
JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
histone H3R2 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables ISS
ISO
IBA
GO_REF:0000024
(PMID:17882261)
GO_REF:0000033
(PMID:17898714)
UniProt
RGD
GO_Central
PMID:17882261 PMID:17898714 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810
JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 enables ISO (PMID:17898714), (PMID:18079182)
(PMID:22904064)
RGD PMID:17898714 PMID:18079182 PMID:22904064 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
histone H3R26 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables ISS
ISO
GO_REF:0000024
(PMID:17882261)
UniProt
RGD
PMID:17882261 GO_REF:0000024 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810
JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
histone H3R8 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810
JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
histone H4R3 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810
JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables ISS
ISO
GO_REF:0000024
(PMID:11448779), (PMID:25284789)
UniProt
RGD
PMID:11448779 PMID:25284789 GO_REF:0000024 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables ISO (PMID:18404153), (PMID:22143770), (PMID:25284789)
(PMID:16699504), (PMID:23133559)
RGD PMID:16699504 PMID:18404153 PMID:22143770 PMID:23133559 PMID:25284789 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 enables ISO (PMID:18079182) RGD PMID:18079182 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prmt7 protein arginine methyltransferase 7 enables ISS
ISO
IEA
GO_REF:0000024
(PMID:17048991)
GO_REF:0000104
UniProt
RGD
PMID:17048991 GO_REF:0000024 GO_REF:0000104 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577
JBrowse link
protein-arginine omega-N asymmetric methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables ISS
ISO
GO_REF:0000024
(PMID:11341840)
UniProt
RGD
PMID:11341840 GO_REF:0000024 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Mettl23 methyltransferase 23, arginine enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr10:102,047,090...102,053,379
Ensembl chr10:102,047,314...102,051,977
JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IDA
IBA
ISO
GO_REF:0000033
(PMID:38006878)
(PMID:15741314), (PMID:16294045), (PMID:25284789), (PMID:26575292), (PMID:26876602), (PMID:27642082), (PMID:29651020)
PMID:19405910
PMID:8663146
GO_Central
RGD
PMID:15741314 PMID:16294045 PMID:25284789 PMID:26575292 PMID:26876602 More... GO_REF:0000033, RGD:61630, RGD:401966877, RGD:61630 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt1l1 protein arginine methyltransferase 1 like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:87,551,165...87,552,305
Ensembl chr14:87,551,207...87,552,294
JBrowse link
G Prmt3 protein arginine methyltransferase 3 IDA RGD PMID:9642256 RGD:729523 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
G Prmt6 protein arginine methyltransferase 6 enables ISO (PMID:11724789), (PMID:16157300), (PMID:17898714), (PMID:18079182), (PMID:30420520) RGD PMID:11724789 PMID:16157300 PMID:17898714 PMID:18079182 PMID:30420520 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prmt8 protein arginine methyltransferase 8 enables ISO
IBA
(PMID:16051612), (PMID:17925405), (PMID:18320585)
GO_REF:0000033
RGD
GO_Central
PMID:16051612 PMID:17925405 PMID:18320585 GO_REF:0000033 NCBI chr 4:160,535,813...160,618,193
Ensembl chr 4:160,535,813...160,617,930
JBrowse link
protein-arginine omega-N monomethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prmt1 protein arginine methyltransferase 1 enables ISO
IBA
IDA
(PMID:26575292)
GO_REF:0000033
PMID:8663146
RGD
GO_Central
PMID:26575292 PMID:8663146 GO_REF:0000033, RGD:61630 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt1l1 protein arginine methyltransferase 1 like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:87,551,165...87,552,305
Ensembl chr14:87,551,207...87,552,294
JBrowse link
G Prmt3 protein arginine methyltransferase 3 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
G Prmt6 protein arginine methyltransferase 6 enables ISO (PMID:11724789), (PMID:16157300), (PMID:16600869) RGD PMID:11724789 PMID:16157300 PMID:16600869 NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prmt7 protein arginine methyltransferase 7 enables ISO
IEA
(PMID:15044439), (PMID:19110445)
GO_REF:0000107
RGD
Ensembl
PMID:15044439 PMID:19110445 GO_REF:0000107 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577
JBrowse link
G Prmt8 protein arginine methyltransferase 8 enables ISO
IBA
(PMID:16051612), (PMID:17925405), (PMID:18320585)
GO_REF:0000033
RGD
GO_Central
PMID:16051612 PMID:17925405 PMID:18320585 GO_REF:0000033 NCBI chr 4:160,535,813...160,618,193
Ensembl chr 4:160,535,813...160,617,930
JBrowse link
protein-arginine omega-N symmetric methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:24089531)
UniProt
GO_Central
RGD
PMID:24089531 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810
JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables ISO (PMID:17709427), (PMID:19011621), (PMID:22143770) RGD PMID:17709427 PMID:19011621 PMID:22143770 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt7 protein arginine methyltransferase 7 enables ISO
IEA
ISS
(PMID:15494416), (PMID:17709427), (PMID:19110445)
(PMID:17048991)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15494416 PMID:17048991 PMID:17709427 PMID:19110445 GO_REF:0000024 GO_REF:0000107 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577
JBrowse link
G Prmt9 protein arginine methyltransferase 9 enables ISO (PMID:25737013) RGD PMID:25737013 NCBI chr19:30,376,342...30,414,491
Ensembl chr19:30,380,124...30,414,458
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20811
    catalytic activity 6119
      catalytic activity, acting on a protein 2576
        protein methyltransferase activity 104
          protein-arginine N-methyltransferase activity 14
            histone H2AR3 methyltransferase activity 2
            histone H3R17 methyltransferase activity 5
            histone H3R2 methyltransferase activity 5
            histone H3R26 methyltransferase activity 4
            histone H3R8 methyltransferase activity 4
            histone H4R3 methyltransferase activity 6
            histone arginine N-methyltransferase activity 4
            protein arginine N5-methyltransferase activity 0
            protein-arginine omega-N asymmetric methyltransferase activity 7
            protein-arginine omega-N monomethyltransferase activity 6
            protein-arginine omega-N symmetric methyltransferase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20811
    catalytic activity 6119
      transferase activity 2465
        transferase activity, transferring one-carbon groups 213
          methyltransferase activity 203
            S-adenosylmethionine-dependent methyltransferase activity 169
              arginine N-methyltransferase activity 14
                protein-arginine N-methyltransferase activity 14
                  histone H2AR3 methyltransferase activity 2
                  histone H3R17 methyltransferase activity 5
                  histone H3R2 methyltransferase activity 5
                  histone H3R26 methyltransferase activity 4
                  histone H3R8 methyltransferase activity 4
                  histone H4R3 methyltransferase activity 6
                  histone arginine N-methyltransferase activity 4
                  protein arginine N5-methyltransferase activity 0
                  protein-arginine omega-N asymmetric methyltransferase activity 7
                  protein-arginine omega-N monomethyltransferase activity 6
                  protein-arginine omega-N symmetric methyltransferase activity 4
paths to the root