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ONTOLOGY REPORT - ANNOTATIONS


Term:RNA polymerase II general transcription initiation factor activity
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Accession:GO:0016251 term browser browse the term
Definition:A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.
Comment:General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur.
Synonyms:exact_synonym: GTF2 activity;   basal RNA polymerase II transcription factor activity;   general RNA polymerase II transcription factor activity
 related_synonym: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity;   RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly;   sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly
 alt_id: GO:0000983;   GO:0001075;   GO:0003703



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RNA polymerase II general transcription initiation factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07015889.1 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr14:78,776,373...78,776,700 JBrowse link
G Brf2 BRF2, RNA polymerase III transcription initiation factor subunit enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059
JBrowse link
G Ccnh cyclin H contributes_to
enables
ISO
IEA
(PMID:7533895)
GO_REF:0000107
RGD
Ensembl
PMID:7533895 GO_REF:0000107 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819
JBrowse link
G Dr1 down-regulator of transcription 1 enables ISO
IBA
IEA
(PMID:8670811)
GO_REF:0000033
GO_REF:0000118
RGD
GO_Central
TreeGrafter
PMID:8670811 GO_REF:0000033 GO_REF:0000118 NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
JBrowse link
G Drap1 Dr1 associated protein 1 enables ISO
IBA
(PMID:8670811)
GO_REF:0000033
RGD
GO_Central
PMID:8670811 GO_REF:0000033 NCBI chr 1:202,731,775...202,734,468
Ensembl chr 1:202,731,788...202,734,425
JBrowse link
G ENSRNOG00000064241 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 5:97,975,779...97,977,813 JBrowse link
G ENSRNOG00000067796 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr15:22,674,189...22,674,524 JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr 6:110,488,891...110,521,502
Ensembl chr 6:110,488,931...110,521,511
JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 enables ISO
IEA
IBA
(PMID:27193682), (PMID:7958899)
GO_REF:0000118
GO_REF:0000033
RGD
TreeGrafter
GO_Central
PMID:7958899 PMID:27193682 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:70,662,447...70,675,576
Ensembl chr 8:70,662,428...70,675,569
JBrowse link
G Gtf2b general transcription factor IIB enables IEA
ISO
IBA
GO_REF:0000107
(PMID:27193682)
GO_REF:0000118
GO_REF:0000033
Ensembl
RGD
TreeGrafter
GO_Central
PMID:27193682 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
JBrowse link
G Gtf2e1 general transcription factor IIE subunit 1 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942
JBrowse link
G Gtf2e2 general transcription factor IIE subunit 2 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr16:58,399,307...58,449,467
Ensembl chr16:58,399,107...58,449,371
JBrowse link
G Gtf2f1 general transcription factor IIF subunit 1 enables ISO
IEA
IBA
(PMID:27193682), (PMID:7929273)
GO_REF:0000118
GO_REF:0000033
RGD
TreeGrafter
GO_Central
PMID:7929273 PMID:27193682 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
JBrowse link
G Gtf2f2 general transcription factor IIF subunit 2 enables IDA PMID:7929273 RGD
ARUK-UCL
PMID:1429731 PMID:7929273 RGD:632949, RGD:9681417 NCBI chr15:51,206,027...51,327,166
Ensembl chr15:51,206,031...51,327,253
JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 enables ISO (PMID:10924514), (PMID:27193682) RGD PMID:10924514 PMID:27193682 NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592
JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 enables ISO
IEA
(PMID:27193682)
GO_REF:0000107
RGD
Ensembl
PMID:27193682 GO_REF:0000107 NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497
JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
JBrowse link
G Prrx1 paired related homeobox 1 enables ISO (PMID:32188878) RGD PMID:32188878 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866
JBrowse link
G Prrx2 paired related homeobox 2 enables ISO (PMID:32188878) RGD PMID:32188878 NCBI chr 3:14,132,574...14,168,533
Ensembl chr 3:14,094,004...14,168,535
JBrowse link
G Snapc2 small nuclear RNA activating complex, polypeptide 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:2,605,794...2,608,997
Ensembl chr12:2,605,810...2,608,999
JBrowse link
G Snapc4 small nuclear RNA activating complex, polypeptide 4 enables ISO (PMID:9418884) RGD PMID:9418884 NCBI chr 3:9,182,061...9,200,819
Ensembl chr 3:9,182,067...9,199,518
JBrowse link
G Snapc5 small nuclear RNA activating complex, polypeptide 5 enables ISO (PMID:9732265) RGD PMID:9732265 NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 enables ISO UniProtKB:Q15545 (PMID:17996705), (PMID:25412659) RGD PMID:17996705 PMID:25412659 NCBI chr  X:66,640,915...66,716,543
Ensembl chr  X:66,640,982...66,716,543
JBrowse link
G Taf10 TATA-box binding protein associated factor 10 contributes_to
enables
ISO
IBA
(PMID:9603525)
(PMID:11564863)
GO_REF:0000033
RGD
GO_Central
PMID:9603525 PMID:11564863 GO_REF:0000033 NCBI chr 1:160,095,108...160,096,401
Ensembl chr 1:160,095,108...160,096,376
JBrowse link
G Taf11 TATA-box binding protein associated factor 11 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:5,955,774...5,963,593
Ensembl chr20:5,955,777...5,961,905
JBrowse link
G Taf12 TATA-box binding protein associated factor 12 contributes_to ISO (PMID:9603525) RGD PMID:9603525 NCBI chr 5:144,472,816...144,490,299
Ensembl chr 5:144,472,841...144,488,849
JBrowse link
G Taf2 TATA-box binding protein associated factor 2 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:86,422,613...86,479,616
Ensembl chr 7:86,422,613...86,479,616
JBrowse link
G Taf4 TATA-box binding protein associated factor 4 contributes_to ISO
IBA
(PMID:9603525)
GO_REF:0000033
RGD
GO_Central
PMID:9603525 GO_REF:0000033 NCBI chr 3:167,017,992...167,083,413
Ensembl chr 3:167,017,993...167,083,356
JBrowse link
G Taf4b TATA-box binding protein associated factor 4b contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307
JBrowse link
G Taf5 TATA-box binding protein associated factor 5 contributes_to
enables
ISO
IBA
(PMID:9603525)
(PMID:9045704)
GO_REF:0000033
RGD
GO_Central
PMID:9045704 PMID:9603525 GO_REF:0000033 NCBI chr 1:245,958,428...245,973,914
Ensembl chr 1:245,958,428...245,973,914
JBrowse link
G Taf6 TATA-box binding protein associated factor 6 contributes_to
enables
ISO
IEA
IBA
(PMID:9603525)
(PMID:15328371)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:9603525 PMID:15328371 GO_REF:0000033 GO_REF:0000107 NCBI chr12:17,055,864...17,064,244
Ensembl chr12:17,055,873...17,064,247
JBrowse link
G Taf6l TATA-box binding protein associated factor 6 like enables IEA GO_REF:0000002
GO_REF:0000118
InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr 1:205,672,147...205,684,721
Ensembl chr 1:205,672,149...205,684,655
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 contributes_to
enables
ISO
IBA
(PMID:9603525)
(PMID:25412659), (PMID:7824954)
GO_REF:0000033
RGD
GO_Central
PMID:7824954 PMID:9603525 PMID:25412659 GO_REF:0000033 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
JBrowse link
G Taf7l TATA-box binding protein associated factor 7-like contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:97,660,222...97,675,241
Ensembl chr  X:97,660,222...97,675,023
JBrowse link
G Taf7l-ps1 TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:51,763,259...51,764,401
Ensembl chr 7:51,763,259...51,764,401
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 enables
contributes_to
IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769
JBrowse link
G Taf9b TATA-box binding protein associated factor 9b contributes_to
enables
IBA
IEA
GO_REF:0000033
GO_REF:0000118
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr  X:71,289,290...71,300,142
Ensembl chr  X:71,289,290...71,300,604
JBrowse link
G Tbp TATA box binding protein contributes_to
enables
IDA
ISO
(PMID:27193682), (PMID:9841876) RGD PMID:9841876 PMID:27193682 PMID:7980586 RGD:2306552 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016
JBrowse link
G Tbpl1 TATA-box binding protein like 1 enables ISO (PMID:10220372), (PMID:15767669) RGD PMID:10220372 PMID:15767669 NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122
Ensembl chr 1:22,778,459...22,803,122
JBrowse link
G Tbpl2 TATA box binding protein-like 2 enables IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 3:6,771,825...6,793,281
Ensembl chr 3:6,772,419...6,793,231
JBrowse link
G Wdr5 WD repeat domain 5 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671
JBrowse link

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