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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of macroautophagy
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Accession:GO:0016242 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
Synonyms:exact_synonym: down regulation of macroautophagy;   downregulation of macroautophagy;   negative regulation of starvation-induced autophagy
 narrow_synonym: inhibition of macroautophagy


show annotations for term's descendants           Sort by:
negative regulation of macroautophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within ISO
IEA 		MGI:2429784 (PMID:20705711)
GO_REF:0000107 		RGD
Ensembl		 PMID:20705711 GO_REF:0000107 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
IEA 		(PMID:19640926)
GO_REF:0000107 		RGD
Ensembl		 PMID:19640926 GO_REF:0000107 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 involved_in ISO (PMID:22354037) RGD PMID:22354037 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203 		JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		(PMID:25327288)
GO_REF:0000107
(PMID:16714284), (PMID:23274896)
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:16714284 PMID:23274896 PMID:25327288 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 acts_upstream_of_or_within ISO
IEA 		MGI:1857409|MGI:1891828 (PMID:17468177)
GO_REF:0000107 		RGD
Ensembl		 PMID:17468177 GO_REF:0000107 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Nrbp2 nuclear receptor binding protein 2 involved_in ISO
IEA 		(PMID:22354037)
GO_REF:0000107 		RGD
Ensembl		 PMID:22354037 GO_REF:0000107 NCBI chr 7:107,798,642...107,805,225
Ensembl chr 7:107,799,497...107,805,230 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO
IEA 		(PMID:19279012)
GO_REF:0000107 		RGD
Ensembl		 PMID:19279012 GO_REF:0000107 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Poldip2 DNA polymerase delta interacting protein 2 acts_upstream_of_or_within ISO
IEA 		MGI:4044390 (PMID:24797518)
GO_REF:0000107 		RGD
Ensembl		 PMID:24797518 GO_REF:0000107 NCBI chr10:63,407,237...63,417,605
Ensembl chr10:63,407,213...63,417,605 		JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 involved_in ISO
IEA 		(PMID:24475161)
GO_REF:0000107 		RGD
Ensembl		 PMID:24475161 GO_REF:0000107 NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459 		JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO
IEA 		(PMID:28195531)
GO_REF:0000107 		RGD
Ensembl		 PMID:28195531 GO_REF:0000107 NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876 		JBrowse link
G Tsc1 TSC complex subunit 1 involved_in IMP PMID:23435171 ParkinsonsUK-UCL PMID:23435171 RGD:10448950 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:24599401 RGD:11568679 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Usp36 ubiquitin specific peptidase 36 involved_in ISO
IEA 		(PMID:22622177)
GO_REF:0000107 		RGD
Ensembl		 PMID:22622177 GO_REF:0000107 NCBI chr10:103,497,349...103,528,877
Ensembl chr10:103,497,349...103,528,877 		JBrowse link
negative regulation of aggrephagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO
IEA 		(PMID:31857589)
GO_REF:0000107 		RGD
Ensembl		 PMID:31857589 GO_REF:0000107 NCBI chr  X:17,222,538...17,244,373
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Lypla1 lysophospholipase 1 involved_in ISO
IEA 		(PMID:37802024)
GO_REF:0000107 		RGD
Ensembl		 PMID:37802024 GO_REF:0000107 NCBI chr 5:19,477,408...19,506,568
Ensembl chr 5:14,679,606...14,708,746 		JBrowse link
negative regulation of autophagosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 acts_upstream_of_or_within ISO
IEA 		MGI:2683833 (PMID:27994061)
GO_REF:0000107 		RGD
Ensembl		 PMID:27994061 GO_REF:0000107 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO (PMID:23918802) RGD PMID:23918802 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 involved_in ISO
IEA
ISS 		(PMID:25495476)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
GO_Central		 PMID:25495476 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:36,544,535...36,589,683 		JBrowse link
G Fez2 fasciculation and elongation protein zeta 2 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:25495476) 		GO_Central
Ensembl
RGD		 PMID:25495476 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:16,654,572...16,694,628
Ensembl chr 6:16,654,614...16,694,626 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
IEA 		(PMID:23916833)
GO_REF:0000107 		RGD
Ensembl		 PMID:23916833 GO_REF:0000107 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mtm1 myotubularin 1 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:2450997 (PMID:23695157) 		GO_Central
RGD		 PMID:23695157 GO_REF:0000033 NCBI chr 6:488,923...506,882
Ensembl chr 6:488,969...506,860 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:20181828) 		UniProt
Ensembl
RGD		 PMID:20181828 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Phf23 PHD finger protein 23 involved_in ISO
IBA
IEA
ISS 		(PMID:25484098)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024 		RGD
GO_Central
Ensembl		 PMID:25484098 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:54,718,663...54,722,784
Ensembl chr10:54,717,724...54,722,782 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO
IEA 		(PMID:19279012)
GO_REF:0000107 		RGD
Ensembl		 PMID:19279012 GO_REF:0000107 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Scfd1 sec1 family domain containing 1 involved_in ISO
IEA 		(PMID:21242315)
GO_REF:0000107 		RGD
Ensembl		 PMID:21242315 GO_REF:0000107 NCBI chr 6:68,795,810...68,874,076
Ensembl chr 6:68,795,878...68,874,078 		JBrowse link
G Sec22b SEC22 homolog B, vesicle trafficking protein involved_in ISO (PMID:21242315) RGD PMID:21242315 NCBI chr 2:185,500,029...185,520,811
Ensembl chr 2:185,500,004...185,522,026 		JBrowse link
G Smcr8 SMCR8-C9orf72 complex subunit involved_in ISO
IEA 		(PMID:28195531)
GO_REF:0000107 		RGD
Ensembl		 PMID:28195531 GO_REF:0000107 NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876 		JBrowse link
G Tmem39a transmembrane protein 39a involved_in ISO
IEA
IBA
ISS 		(PMID:31806350)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000024 		RGD
Ensembl
GO_Central
UniProt		 PMID:31806350 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964 		JBrowse link
negative regulation of autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A involved_in ISO
IEA 		(PMID:28223137)
GO_REF:0000107 		RGD
Ensembl		 PMID:28223137 GO_REF:0000107 NCBI chr10:4,927,799...5,123,749
Ensembl chr10:4,928,030...5,123,578 		JBrowse link
G Phf23 PHD finger protein 23 involved_in ISO
IBA
IEA
ISS 		(PMID:25484098)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024 		RGD
GO_Central
Ensembl		 PMID:25484098 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:54,718,663...54,722,784
Ensembl chr10:54,717,724...54,722,782 		JBrowse link
G Rubcn rubicon autophagy regulator involved_in ISO
IBA 		(PMID:21062745)
GO_REF:0000033 		RGD
GO_Central		 PMID:21062745 GO_REF:0000033 NCBI chr11:67,907,534...67,964,347
Ensembl chr11:67,907,516...67,964,314 		JBrowse link
G Tmem39a transmembrane protein 39a involved_in ISO
IEA
IBA
ISS 		(PMID:31806350)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000024 		RGD
Ensembl
GO_Central
UniProt		 PMID:31806350 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964 		JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO
IEA 		(PMID:23459205)
GO_REF:0000107 		RGD
Ensembl		 PMID:23459205 GO_REF:0000107 NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059 		JBrowse link
negative regulation of mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain containing 16A acts_upstream_of_or_within ISO MGI:5648633 (PMID:24949970) RGD PMID:24949970 NCBI chr10:4,927,799...5,123,749
Ensembl chr10:4,928,030...5,123,578 		JBrowse link
G Fbxl4 F-box and leucine-rich repeat protein 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:38992176) 		Ensembl
RGD		 PMID:38992176 GO_REF:0000107 NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO
IEA 		(PMID:19279012)
GO_REF:0000107 		RGD
Ensembl		 PMID:19279012 GO_REF:0000107 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pptc7 protein phosphatase targeting COQ7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:38992176) 		Ensembl
RGD		 PMID:38992176 GO_REF:0000107 NCBI chr12:34,249,963...34,288,339
Ensembl chr12:34,249,977...34,288,339 		JBrowse link
G Rnf41 ring finger protein 41 acts_upstream_of_or_within ISO
IEA 		MGI:1921624 (PMID:24949970)
GO_REF:0000107 		RGD
Ensembl		 PMID:24949970 GO_REF:0000107 NCBI chr 7:1,422,651...1,461,700
Ensembl chr 7:838,203...865,511 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO
IEA 		MGI:5319187 (PMID:22044588)
GO_REF:0000107 		RGD
Ensembl		 PMID:22044588 GO_REF:0000107 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
Ensembl chr 6:159,927,139...159,946,029 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO
IEA 		MGI:1857263 (PMID:22044588)
GO_REF:0000107 		RGD
Ensembl		 PMID:22044588 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tspo translocator protein involved_in ISO
IEA 		(PMID:25470454)
GO_REF:0000107 		RGD
Ensembl		 PMID:25470454 GO_REF:0000107 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Usp30 ubiquitin specific peptidase 30 IMP RGD PMID:24896179 RGD:13208875 NCBI chr12:42,501,345...42,555,311
Ensembl chr12:42,501,348...42,555,616 		JBrowse link
negative regulation of type 2 mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra2 HtrA serine peptidase 2 involved_in ISO
IEA 		(PMID:24709290)
GO_REF:0000107 		RGD
Ensembl		 PMID:24709290 GO_REF:0000107 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Vps13c vacuolar protein sorting 13 homolog C involved_in ISO
IEA
ISS 		(PMID:26942284)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
ParkinsonsUK-UCL		 PMID:26942284 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:68,478,366...68,651,893
Ensembl chr 8:68,478,395...68,651,895 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      process utilizing autophagic mechanism 564
        autophagy 564
          macroautophagy 335
            negative regulation of macroautophagy 37
              negative regulation of aggrephagy 2
              negative regulation of autophagosome assembly 13
              negative regulation of autophagosome maturation 5
              negative regulation of lipophagy 0
              negative regulation of mitophagy + 11
              negative regulation of xenophagy 0
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        negative regulation of biological process 5844
          negative regulation of cellular process 5621
            negative regulation of metabolic process 3159
              negative regulation of catabolic process 389
                negative regulation of autophagy 95
                  negative regulation of macroautophagy 37
                    negative regulation of aggrephagy 2
                    negative regulation of autophagosome assembly 13
                    negative regulation of autophagosome maturation 5
                    negative regulation of lipophagy 0
                    negative regulation of mitophagy + 11
                    negative regulation of xenophagy 0
paths to the root