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ONTOLOGY REPORT - ANNOTATIONS

Term:catechol O-methyltransferase activity
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Accession:GO:0016206 term browser browse the term
Definition:Catalysis of the reaction: a catechol + S-adenosyl-L-methionine = a guaiacol + H+ + S-adenosyl-L-homocysteine. Acts on catechols and on catecholamines such as adrenaline or noradrenaline.
Synonyms:related_synonym: COMT I;   COMT II;   MB-COMT (membrane-bound form of catechol-O-methyltransferase);   S-COMT (soluble form of catechol-O-methyltransferase);   S-adenosyl-L-methionine:catechol O-methyltransferase activity;   catechol methyltransferase activity;   catecholamine O-methyltransferase activity
 xref: EC:2.1.1.6;   MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN;   RHEA:17877;   Reactome:R-HSA-8955010 "LRTOMT transfers Met to DA, forming 3MT";   reactome:R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ"
 never_in_taxon: NCBITaxon:4890 ! Ascomycota


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catechol O-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase enables IDA
ISO
IEA
IBA		 (PMID:11559542), (PMID:15645182), (PMID:21846718)
GO_REF:0000104
GO_REF:0000107
GO_REF:0000033
(PMID:12188925), (PMID:17724020), (PMID:20374420), (PMID:20618449), (PMID:24509724), (PMID:27388330)
GO_REF:0000002
GO_REF:0000003
GO_REF:0000116		 RGD
UniProt
Ensembl
GO_Central
InterPro
RHEA		 PMID:11559542 PMID:12188925 PMID:15645182 PMID:17724020 PMID:20374420 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116, RGD:1359089 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Lrtomt leucine rich transmembrane and O-methyltransferase domain containing enables ISS
IBA
ISO
IEA		 GO_REF:0000024
GO_REF:0000033
(PMID:18794526)
GO_REF:0000003
GO_REF:0000107
GO_REF:0000116		 UniProt
GO_Central
RGD
Ensembl
RHEA		 PMID:18794526 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 1:165,678,654...165,680,703
Ensembl chr 1:156,266,655...156,268,704 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      transferase activity 2476
        transferase activity, transferring one-carbon groups 215
          methyltransferase activity 204
            S-adenosylmethionine-dependent methyltransferase activity 170
              catechol O-methyltransferase activity 2
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