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ONTOLOGY REPORT - ANNOTATIONS

Term:sterol metabolic process
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Accession:GO:0016125 term browser browse the term
Definition:The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Synonyms:exact_synonym: sterol metabolism


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sterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arv1 ARV1 homolog, fatty acid homeostasis modulator involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:125,448,765...125,469,533
Ensembl chr 8:125,448,878...125,460,862 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within IMP (PMID:14684813) MGI PMID:14684813 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310 		JBrowse link
G Ebpl emopamil binding protein-like involved_in IEA InterPro GO_REF:0000002 NCBI chr14:61,577,212...61,597,894
Ensembl chr14:61,569,191...61,597,888 		JBrowse link
G Gm8978 predicted gene 8978 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:33,590,549...33,602,649
Ensembl chr19:33,590,107...33,602,652 		JBrowse link
G Lipa lysosomal acid lipase A involved_in
acts_upstream_of_or_within		 ISO
IBA
IMP		 (PMID:21289032), (PMID:21697390), (PMID:25147230) RGD
GO_Central
MGI		 PMID:10419291 PMID:21289032 PMID:21697390 PMID:25147230 GO_REF:0000033 GO_REF:0000096 RGD:1626385 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Lipo1 lipase, member O1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:33,753,437...33,764,852
Ensembl chr19:33,752,898...33,764,859 		JBrowse link
G Lipo2 lipase, member O2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:33,697,067...33,739,461
Ensembl chr19:33,697,070...33,728,759 		JBrowse link
G Lipo3 lipase, member O3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:33,532,560...33,568,069
Ensembl chr19:33,532,560...33,739,351 		JBrowse link
G Lipo4 lipase, member O4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:33,476,449...33,495,170
Ensembl chr19:33,475,437...33,495,180 		JBrowse link
G Lss lanosterol synthase involved_in ISO RGD
GO_Central		 PMID:16440058 GO_REF:0000096 RGD:1626611 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 acts_upstream_of_or_within IMP (PMID:21289032), (PMID:21697390) MGI PMID:21289032 PMID:21697390 NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457 		JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 acts_upstream_of_or_within IMP (PMID:21289032) MGI PMID:21289032 NCBI chr12:84,801,333...84,819,886
Ensembl chr12:84,801,336...84,819,926 		JBrowse link
cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A-I acts_upstream_of_or_within IMP (PMID:8647961) MGI PMID:8647961 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Ces1a carboxylesterase 1A involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,746,842...93,774,820
Ensembl chr 8:93,746,842...93,774,820 		JBrowse link
G Ces1b carboxylesterase 1B involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,783,353...93,806,645
Ensembl chr 8:93,783,356...93,806,645 		JBrowse link
G Ces1c carboxylesterase 1C involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,825,643...93,857,911
Ensembl chr 8:93,825,643...93,857,911 		JBrowse link
G Ces1d carboxylesterase 1D involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Ces1e carboxylesterase 1E involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,927,846...93,956,233
Ensembl chr 8:93,927,846...93,956,247 		JBrowse link
G Ces1f carboxylesterase 1F involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,982,864...94,006,394
Ensembl chr 8:93,982,864...94,006,375 		JBrowse link
G Ces1g carboxylesterase 1G involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:94,028,997...94,063,837
Ensembl chr 8:94,028,997...94,063,936 		JBrowse link
G Ces1h carboxylesterase 1H involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:94,078,468...94,106,405
Ensembl chr 8:94,078,471...94,106,353 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator acts_upstream_of_or_within IMP (PMID:17085523) MGI PMID:17085523 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793 		JBrowse link
G Cyp51 cytochrome P450, family 51 acts_upstream_of_or_within TAS (PMID:10864439) MGI PMID:10864439 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within
involved_in		 IMP
ISO		 (PMID:14684813), (PMID:16321981), (PMID:16513830)
(PMID:11519011)		 MGI
UniProt		 PMID:11519011 PMID:14684813 PMID:16321981 PMID:16513830 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO
IEA
IBA		 RGD
GO_Central
UniProt		 PMID:9831636 PMID:10329655 GO_REF:0000033 GO_REF:0000041 GO_REF:0000096 GO_REF:0000119 RGD:2316918 RGD:632010 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Ebp EBP cholestenol delta-isomerase involved_in ISO
ISS
IBA
IEA		 RGD
UniProt
GO_Central		 PMID:11171067 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000096 GO_REF:0000119 RGD:628445 NCBI chr  X:8,051,568...8,059,751
Ensembl chr  X:8,051,568...8,059,751 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 involved_in ISO
IEA
IBA		 RGD
UniProt
GO_Central		 PMID:16440058 GO_REF:0000033 GO_REF:0000043 GO_REF:0000096 RGD:1626611 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027 		JBrowse link
G Fdps farnesyl diphosphate synthetase involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266 		JBrowse link
G G6pd2 glucose-6-phosphate dehydrogenase 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 5:61,966,186...61,967,820
Ensembl chr 5:61,966,159...61,968,506 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked involved_in ISO GO_Central GO_REF:0000119 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase acts_upstream_of_or_within
involved_in		 IDA
ISO		 (PMID:15845870), (PMID:7798939), (PMID:8647961) MGI
GO_Central		 PMID:7798939 PMID:8647961 PMID:15845870 GO_REF:0000119 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 (PMID:12829805) MGI
GO_Central		 PMID:12829805 GO_REF:0000033 GO_REF:0000119 NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase involved_in IEA UniProt GO_REF:0000043 NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487 		JBrowse link
G Insig1 insulin induced gene 1 acts_upstream_of_or_within
involved_in		 IGI
IBA
ISO		 (PMID:16955138) MGI
GO_Central		 PMID:16955138 GO_REF:0000033 GO_REF:0000119 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Insig2 insulin induced gene 2 acts_upstream_of_or_within
involved_in		 IGI
IBA
ISS
ISO		 (PMID:16955138) MGI
GO_Central
UniProt		 PMID:16955138 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318 		JBrowse link
G Lbr lamin B receptor involved_in IMP
IBA
ISO
IEA
IDA		 (PMID:22140257)
(PMID:18785926)		 UniProt
GO_Central		 PMID:18785926 PMID:22140257 GO_REF:0000033 GO_REF:0000041 GO_REF:0000119 NCBI chr 1:181,642,880...181,669,933
Ensembl chr 1:181,642,900...181,670,611 		JBrowse link
G Lipa lysosomal acid lipase A acts_upstream_of_or_within IMP (PMID:25147230), (PMID:29599133) MGI PMID:25147230 PMID:29599133 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Lss lanosterol synthase involved_in ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:1429550 PMID:16440058 GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 RGD:1626611 RGD:2316919 NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972 		JBrowse link
G Msmo1 methylsterol monoxygenase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826 		JBrowse link
G Mvd mevalonate (diphospho) decarboxylase involved_in IEA UniProt GO_REF:0000041 NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161 		JBrowse link
G Mvk mevalonate kinase involved_in IBA
IEA
ISO		 GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 GO_REF:0000119 NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr11:6,161,011...6,180,245
Ensembl chr11:6,161,013...6,180,143 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like involved_in IEA UniProt GO_REF:0000043 NCBI chr  X:71,962,127...72,002,134
Ensembl chr  X:71,962,163...72,002,120 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in IBA
ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 3:89,361,848...89,376,321
Ensembl chr 3:89,361,848...89,376,320 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit involved_in IEA UniProt GO_REF:0000043 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of IMP (PMID:9329978) MGI PMID:9329978 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 involved_in IDA
IBA
ISO
IEA		 (PMID:18785926) UniProt
GO_Central		 PMID:18785926 GO_REF:0000033 GO_REF:0000041 GO_REF:0000119 NCBI chr19:6,112,851...6,117,880
Ensembl chr19:6,112,851...6,118,403 		JBrowse link
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 involved_in ISO
IBA		 RGD
GO_Central		 PMID:7581240 GO_REF:0000033 GO_REF:0000096 RGD:2316902 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
cholesterol biosynthetic process via desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhcr24 24-dehydrocholesterol reductase involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310 		JBrowse link
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO (PMID:38297129), (PMID:38297130) UniProt PMID:38297129 PMID:38297130 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Sc5d sterol-C5-desaturase involved_in ISO
ISS
IBA		 RGD
GO_Central
UniProt		 PMID:7961720 GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 RGD:2316911 NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552 		JBrowse link
cholesterol catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 6:37,506,913...37,551,856
Ensembl chr 6:37,507,108...37,545,750 		JBrowse link
G Apoe apolipoprotein E acts_upstream_of_or_within IMP (PMID:9826706) MGI PMID:9826706 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in ISS
IEA
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000041 GO_REF:0000119 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 acts_upstream_of_or_within
involved_in		 IDA
IEA		 (PMID:10748047) MGI
UniProt		 PMID:10748047 GO_REF:0000041 NCBI chr17:43,978,263...44,062,322
Ensembl chr17:43,978,316...44,062,322 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 involved_in ISS
IBA
ISO
IDA
IEA		 (PMID:10377398), (PMID:20193040) UniProt
GO_Central
ARUK-UCL		 PMID:10377398 PMID:20193040 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000119 NCBI chr12:108,300,568...108,328,497
Ensembl chr12:108,300,640...108,328,493 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 acts_upstream_of_or_within
involved_in		 IDA
IEA
ISS
ISO		 (PMID:11279518), (PMID:15845870) MGI
UniProt
GO_Central		 PMID:11279518 PMID:15845870 GO_REF:0000024 GO_REF:0000041 GO_REF:0000096 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 involved_in ISO RGD
GO_Central		 PMID:16081591 GO_REF:0000096 RGD:1599972 NCBI chr 7:127,399,830...127,402,973
Ensembl chr 7:127,399,776...127,402,974 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 acts_upstream_of_or_within IMP
IDA		 (PMID:10559220)
(PMID:11278646)		 MGI PMID:10559220 PMID:11278646 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158 		JBrowse link
cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 acts_upstream_of_or_within
involved_in		 IDA
ISO		 (PMID:11559713) MGI
GO_Central		 PMID:11559713 GO_REF:0000119 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abca2 ATP-binding cassette, sub-family A member 2 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr 2:25,318,611...25,338,556
Ensembl chr 2:25,318,715...25,338,552 		JBrowse link
G Abca5 ATP-binding cassette, sub-family A member 5 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr11:110,160,195...110,228,542
Ensembl chr11:110,160,195...110,228,542 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Angptl3 angiopoietin-like 3 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:98,919,191...98,926,429
Ensembl chr 4:98,919,191...98,934,348 		JBrowse link
G Aplp2 amyloid beta precursor-like protein 2 acts_upstream_of_or_within IGI (PMID:17920016) MGI PMID:17920016 NCBI chr 9:31,060,853...31,123,144
Ensembl chr 9:31,060,853...31,123,111 		JBrowse link
G Apoa1 apolipoprotein A-I acts_upstream_of_or_within
involved_in		 IGI
IBA
ISO
IMP		 (PMID:15995171)
(PMID:10357841), (PMID:15466405), (PMID:17071966), (PMID:7751823), (PMID:9327769), (PMID:9795222)		 MGI
GO_Central		 PMID:7751823 PMID:9327769 PMID:9795222 PMID:10357841 PMID:15466405 More... GO_REF:0000033 GO_REF:0000119 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoa2 apolipoprotein A-II acts_upstream_of_or_within IMP
IGI		 (PMID:10357838), (PMID:8647961) MGI PMID:8647961 PMID:10357838 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948 		JBrowse link
G Apoa4 apolipoprotein A-IV involved_in ISO
IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Apoa5 apolipoprotein A-V involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217 		JBrowse link
G Apob apolipoprotein B involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apobr apolipoprotein B receptor involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:126,184,092...126,188,297
Ensembl chr 7:126,184,114...126,188,284 		JBrowse link
G Apoc1 apolipoprotein C-I acts_upstream_of_or_within IMP (PMID:7848292) MGI PMID:7848292 NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585 		JBrowse link
G Apoc3 apolipoprotein C-III acts_upstream_of_or_within IMP (PMID:8864964)
(PMID:11590213), (PMID:8089130)		 MGI PMID:8089130 PMID:8864964 PMID:11590213 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Apoe apolipoprotein E acts_upstream_of_or_within
involved_in		 IMP
IBA
ISO		 (PMID:1423598), (PMID:8647961) MGI
GO_Central		 PMID:1423598 PMID:8647961 GO_REF:0000033 GO_REF:0000119 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Apof apolipoprotein F involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:22363685) GO_Central
MGI		 PMID:22363685 GO_REF:0000033 NCBI chr10:128,104,568...128,107,119
Ensembl chr10:128,103,866...128,106,022 		JBrowse link
G Apon apolipoprotein N involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:128,090,000...128,091,770
Ensembl chr10:128,089,965...128,091,765 		JBrowse link
G App amyloid beta precursor protein acts_upstream_of_or_within IMP
IGI		 (PMID:17920016) MGI PMID:17920016 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator involved_in IEA UniProt GO_REF:0000043 NCBI chr 8:125,448,765...125,469,533
Ensembl chr 8:125,448,878...125,460,862 		JBrowse link
G Cat catalase acts_upstream_of_or_within IMP (PMID:5087482) MGI PMID:5087482 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha acts_upstream_of_or_within IMP (PMID:18974039) MGI PMID:18974039 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Ces1a carboxylesterase 1A involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,746,842...93,774,820
Ensembl chr 8:93,746,842...93,774,820 		JBrowse link
G Ces1b carboxylesterase 1B involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,783,353...93,806,645
Ensembl chr 8:93,783,356...93,806,645 		JBrowse link
G Ces1c carboxylesterase 1C involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,825,643...93,857,911
Ensembl chr 8:93,825,643...93,857,911 		JBrowse link
G Ces1d carboxylesterase 1D involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Ces1e carboxylesterase 1E involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,927,846...93,956,233
Ensembl chr 8:93,927,846...93,956,247 		JBrowse link
G Ces1f carboxylesterase 1F involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,982,864...94,006,394
Ensembl chr 8:93,982,864...94,006,375 		JBrowse link
G Ces1g carboxylesterase 1G involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 8:94,028,997...94,063,837
Ensembl chr 8:94,028,997...94,063,936 		JBrowse link
G Ces1h carboxylesterase 1H involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:94,078,468...94,106,405
Ensembl chr 8:94,078,471...94,106,353 		JBrowse link
G Ch25h cholesterol 25-hydroxylase acts_upstream_of_or_within
involved_in		 IDA
IBA
ISO		 (PMID:9852097) MGI
GO_Central		 PMID:9852097 GO_REF:0000033 GO_REF:0000119 NCBI chr19:34,451,183...34,452,548
Ensembl chr19:34,451,178...34,452,564 		JBrowse link
G Cln6 ceroid-lipofuscinosis, neuronal 6 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 9:62,746,067...62,759,288
Ensembl chr 9:62,746,067...62,759,288 		JBrowse link
G Cln8 CLN8 transmembrane ER and ERGIC protein involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 8:14,931,335...14,951,720
Ensembl chr 8:14,931,335...14,951,720 		JBrowse link
G Cubn cubilin involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:13,281,149...13,496,687
Ensembl chr 2:13,281,149...13,496,624 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IEA
IBA
ISO
ISS		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000119 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:74,706,741...74,713,492
Ensembl chr15:74,705,974...74,713,492 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,467...74,728,167 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 involved_in IEA UniProt GO_REF:0000041 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in ISO
IBA		 RGD
GO_Central		 PMID:2175615 GO_REF:0000033 GO_REF:0000096 RGD:1299597 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:18,126,108...18,298,054
Ensembl chr 3:18,126,114...18,297,502 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within IMP (PMID:16407971) MGI PMID:16407971 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310 		JBrowse link
G Disp3 dispatched RND transporter family member 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:148,320,890...148,372,653
Ensembl chr 4:148,324,721...148,372,422 		JBrowse link
G Ebp EBP cholestenol delta-isomerase involved_in ISO (PMID:10391219) GO_Central PMID:10391219 NCBI chr  X:8,051,568...8,059,751
Ensembl chr  X:8,051,568...8,059,751 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:44,023,382...44,058,580
Ensembl chr19:44,023,383...44,058,224 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 8:27,513,399...27,529,465
Ensembl chr 8:27,513,289...27,530,356 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 acts_upstream_of_or_within IMP (PMID:28053990)
(PMID:22912762)		 MGI PMID:22912762 PMID:28053990 NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349 		JBrowse link
G Fdx1 ferredoxin 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 9:51,854,323...51,874,902
Ensembl chr 9:51,854,606...51,874,856 		JBrowse link
G Fdxr ferredoxin reductase involved_in IEA UniProt GO_REF:0000041 NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876 		JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within IMP (PMID:11160364) MGI PMID:11160364 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322 		JBrowse link
G Fgl1 fibrinogen-like protein 1 acts_upstream_of_or_within IMP (PMID:23483972) MGI PMID:23483972 NCBI chr 8:41,644,471...41,671,015
Ensembl chr 8:41,644,471...41,668,193 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in IDA
IEA
ISO		 (PMID:24211208) UniProt
GO_Central		 PMID:24211208 GO_REF:0000041 GO_REF:0000119 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Gba2 glucosidase beta 2 involved_in IEA
IMP		 (PMID:26724485) UniProt PMID:26724485 GO_REF:0000041 NCBI chr 4:43,566,928...43,578,893
Ensembl chr 4:43,566,928...43,578,873 		JBrowse link
G Hdlbp high density lipoprotein (HDL) binding protein involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:93,333,662...93,406,639
Ensembl chr 1:93,333,662...93,406,537 		JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within IMP (PMID:11279518) MGI PMID:11279518 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153 		JBrowse link
G Il4 interleukin 4 involved_in IMP (PMID:11971948) UniProt PMID:11971948 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Insig1 insulin induced gene 1 acts_upstream_of_or_within IGI (PMID:16100574) MGI PMID:16100574 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Insig2 insulin induced gene 2 acts_upstream_of_or_within IGI (PMID:16100574) MGI PMID:16100574 NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318 		JBrowse link
G Lcat lecithin cholesterol acyltransferase involved_in
acts_upstream_of_or_within		 ISO
IDA		 (PMID:9300780)
(PMID:10559507)		 RGD
GO_Central
MGI		 PMID:746355 PMID:9300780 PMID:10559507 GO_REF:0000096 GO_REF:0000119 RGD:1581789 NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014 		JBrowse link
G Ldlr low density lipoprotein receptor acts_upstream_of_or_within IMP (PMID:17071966) MGI PMID:17071966 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:134,468,865...134,495,342
Ensembl chr 4:134,468,865...134,495,335 		JBrowse link
G Lep leptin acts_upstream_of_or_within IGI (PMID:15995171) MGI PMID:15995171 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor acts_upstream_of_or_within IGI (PMID:15995171) MGI PMID:15995171 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lima1 LIM domain and actin binding 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:99,676,351...99,773,292
Ensembl chr15:99,676,351...99,773,337 		JBrowse link
G Lipa lysosomal acid lipase A acts_upstream_of_or_within IMP (PMID:30639734)
(PMID:24370824)		 MGI PMID:24370824 PMID:30639734 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Lipc lipase, hepatic acts_upstream_of_or_within IGI (PMID:10357838) MGI PMID:10357838 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lipe lipase, hormone sensitive involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 acts_upstream_of_or_within IMP (PMID:17920016) MGI PMID:17920016 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 acts_upstream_of_or_within IMP (PMID:12509515) MGI PMID:12509515 NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 8:120,234,890...120,285,603
Ensembl chr 8:120,234,895...120,285,474 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr  X:156,330,818...156,381,711
Ensembl chr  X:156,318,367...156,381,711 		JBrowse link
G Mttp microsomal triglyceride transfer protein involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Nfe2l1 nuclear factor, erythroid derived 2,-like 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:96,708,239...96,720,810
Ensembl chr11:96,708,240...96,720,794 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:6,161,011...6,180,245
Ensembl chr11:6,161,013...6,180,143 		JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr12:84,801,333...84,819,886
Ensembl chr12:84,801,336...84,819,926 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:10369263) MGI
GO_Central		 PMID:10369263 GO_REF:0000033 NCBI chr  X:71,962,127...72,002,134
Ensembl chr  X:71,962,163...72,002,120 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 acts_upstream_of_or_within IDA (PMID:17242417) MGI PMID:17242417 NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526 		JBrowse link
G Pctp phosphatidylcholine transfer protein acts_upstream_of_or_within IMP (PMID:15845870) MGI PMID:15845870 NCBI chr11:89,873,370...89,893,720
Ensembl chr11:89,873,491...89,893,720 		JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr14:51,164,672...51,168,306
Ensembl chr14:51,163,525...51,168,313 		JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within IMP (PMID:25429154) MGI PMID:25429154 NCBI chr11:63,019,808...63,050,373
Ensembl chr11:63,019,808...63,050,373 		JBrowse link
G Pon1 paraoxonase 1 acts_upstream_of_or_within IMP
TAS		 (PMID:9685159)
(PMID:10393212)		 MGI PMID:9685159 PMID:10393212 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Saa1 serum amyloid A 1 acts_upstream_of_or_within IDA (PMID:9300780) MGI PMID:9300780 NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404 		JBrowse link
G Scap SREBF chaperone acts_upstream_of_or_within IDA (PMID:11358865) MGI PMID:11358865 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal acts_upstream_of_or_within IMP (PMID:22383528) MGI PMID:22383528 NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596 		JBrowse link
G Soat1 sterol O-acyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IBA
IDA		 (PMID:15845870) MGI
GO_Central		 PMID:15845870 GO_REF:0000008 GO_REF:0000033 GO_REF:0000119 NCBI chr 1:156,255,678...156,301,898
Ensembl chr 1:156,252,095...156,301,901 		JBrowse link
G Soat2 sterol O-acyltransferase 2 involved_in
acts_upstream_of_or_within		 ISO
IBA
IDA		 (PMID:9756919) RGD
GO_Central
MGI		 PMID:9756919 PMID:12217884 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:625687 NCBI chr15:102,058,853...102,071,871
Ensembl chr15:102,058,961...102,071,904 		JBrowse link
G Sqle squalene epoxidase involved_in ISO
IEA
IBA		 RGD
GO_Central
Ensembl		 PMID:9300786 GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 RGD:1625701 NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in ISO RGD
GO_Central		 PMID:18071061 GO_REF:0000096 RGD:1643359 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G Star steroidogenic acute regulatory protein involved_in IEA UniProt GO_REF:0000041 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
G Sult1c1 sulfotransferase family, cytosolic, 1C, member 1 involved_in ISO (PMID:28992322) UniProt PMID:28992322 NCBI chr17:54,268,643...54,297,659
Ensembl chr17:54,268,643...54,297,702 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Sult2a2 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:13,467,431...13,513,562
Ensembl chr 7:13,467,430...13,513,561 		JBrowse link
G Sult2a3 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:13,801,480...13,856,973
Ensembl chr 7:13,801,371...13,856,969 		JBrowse link
G Sult2a4 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:13,643,602...13,723,516
Ensembl chr 7:13,643,601...13,723,532 		JBrowse link
G Sult2a5 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:13,357,892...13,404,732
Ensembl chr 7:13,357,892...13,404,732 		JBrowse link
G Sult2a6 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:13,956,328...13,988,795
Ensembl chr 7:13,956,328...13,988,795 		JBrowse link
G Sult2a7 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 7 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:14,198,976...14,226,948
Ensembl chr 7:14,198,976...14,228,155 		JBrowse link
G Sult2a8 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:14,144,611...14,180,705
Ensembl chr 7:14,144,611...14,180,694 		JBrowse link
G Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 7:45,379,405...45,409,096
Ensembl chr 7:45,379,407...45,434,093 		JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 acts_upstream_of_or_within IMP (PMID:3473481) MGI PMID:3473481 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981 		JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan involved_in IMP (PMID:31391339) UniProt PMID:31391339 NCBI chr 7:97,999,875...98,010,602
Ensembl chr 7:97,999,875...98,010,535 		JBrowse link
G Vldlr very low density lipoprotein receptor involved_in IEA UniProt GO_REF:0000043 NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 3110082I17Rik RIKEN cDNA 3110082I17 gene involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:139,345,494...139,446,291
Ensembl chr 5:139,345,494...139,446,282 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 RGD
GO_Central
Ensembl		 PMID:9225228 GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 RGD:10059686 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr19:44,023,382...44,058,580
Ensembl chr19:44,023,383...44,058,224 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 8:27,513,399...27,529,465
Ensembl chr 8:27,513,289...27,530,356 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within IMP (PMID:17202134) MGI PMID:17202134 NCBI chr13:9,002,899...9,010,981
Ensembl chr13:9,002,899...9,010,981 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO (PMID:26311497) UniProt PMID:26311497 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO (PMID:24296663)
(PMID:23951060)		 BHF-UCL PMID:23951060 PMID:24296663 NCBI chr16:18,145,265...18,145,329
Ensembl chr16:18,145,265...18,145,329 		JBrowse link
G Mir342 microRNA 342 acts_upstream_of ISO (PMID:23951060) BHF-UCL PMID:23951060 NCBI chr12:108,624,879...108,624,977
Ensembl chr12:108,624,879...108,624,977 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:30195495) BHF-UCL PMID:30195495 NCBI chr  X:150,696,210...150,696,317
Ensembl chr  X:150,696,210...150,696,317 		JBrowse link
G Sod1 superoxide dismutase 1, soluble involved_in ISO GO_Central GO_REF:0000119 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
negative regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ch25h cholesterol 25-hydroxylase involved_in IDA (PMID:29033131) UniProt PMID:29033131 NCBI chr19:34,451,183...34,452,548
Ensembl chr19:34,451,178...34,452,564 		JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IMP (PMID:17916878) BHF-UCL PMID:17916878 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in IMP (PMID:17916878) BHF-UCL PMID:17916878 NCBI chr 9:44,184,485...44,199,953
Ensembl chr 9:44,184,485...44,199,912 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000096 GO_REF:0000107 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Fdps farnesyl diphosphate synthetase involved_in ISO RGD
GO_Central		 PMID:18637708 GO_REF:0000096 RGD:2316295 NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266 		JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Gnai1 G protein subunit alpha i1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 involved_in ISO (PMID:11163209) UniProt PMID:11163209 NCBI chr  X:156,330,818...156,381,711
Ensembl chr  X:156,318,367...156,381,711 		JBrowse link
G Mir182 microRNA 182 involved_in ISO (PMID:23823476) BHF-UCL PMID:23823476 NCBI chr 6:30,165,917...30,165,991
Ensembl chr 6:30,165,917...30,165,991 		JBrowse link
G Mir96 microRNA 96 involved_in
acts_upstream_of		 ISO (PMID:23823476)
(PMID:30460077)		 BHF-UCL PMID:23823476 PMID:30460077 NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 involved_in ISO RGD
GO_Central		 PMID:32976883 GO_REF:0000096 RGD:405096663 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member III involved_in ISO (PMID:26311497) UniProt PMID:26311497 NCBI chr 5:97,229,223...97,259,608
Ensembl chr 5:97,230,188...97,259,455 		JBrowse link
G Por cytochrome p450 oxidoreductase involved_in ISO GO_Central GO_REF:0000096 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072 		JBrowse link
G Qki quaking, KH domain containing RNA binding involved_in IMP (PMID:33942715) UniProt PMID:33942715 NCBI chr17:10,425,480...10,538,706
Ensembl chr17:10,421,530...10,538,783 		JBrowse link
G Scap SREBF chaperone involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018 		JBrowse link
G Scp2 sterol carrier protein 2, liver involved_in ISO RGD
GO_Central		 PMID:2554812 GO_REF:0000096 RGD:9850260 NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 involved_in ISO RGD
GO_Central		 PMID:11226224 GO_REF:0000096 RGD:727312 NCBI chr11:4,047,039...4,068,729
Ensembl chr11:4,047,039...4,073,415 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within
involved_in		 IMP
IDA
ISO
ISS		 (PMID:9329978)
(PMID:8833906), (PMID:9062341)
(PMID:16046411)		 MGI
UniProt
GO_Central		 PMID:8833906 PMID:9062341 PMID:9329978 PMID:16046411 GO_REF:0000024 GO_REF:0000119 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 involved_in IMP
IEA
ISS
ISO		 (PMID:33942715), (PMID:34021134) UniProt
Ensembl
GO_Central		 PMID:33942715 PMID:34021134 GO_REF:0000024 GO_REF:0000107 GO_REF:0000119 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
positive regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A-I involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoe apolipoprotein E involved_in IMP
ISO		 (PMID:15654758) BHF-UCL
GO_Central		 PMID:15654758 GO_REF:0000119 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Ces1a carboxylesterase 1A involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,746,842...93,774,820
Ensembl chr 8:93,746,842...93,774,820 		JBrowse link
G Ces1b carboxylesterase 1B involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,783,353...93,806,645
Ensembl chr 8:93,783,356...93,806,645 		JBrowse link
G Ces1c carboxylesterase 1C involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,825,643...93,857,911
Ensembl chr 8:93,825,643...93,857,911 		JBrowse link
G Ces1d carboxylesterase 1D involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Ces1e carboxylesterase 1E involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,927,846...93,956,233
Ensembl chr 8:93,927,846...93,956,247 		JBrowse link
G Ces1f carboxylesterase 1F involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:93,982,864...94,006,394
Ensembl chr 8:93,982,864...94,006,375 		JBrowse link
G Ces1g carboxylesterase 1G involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 8:94,028,997...94,063,837
Ensembl chr 8:94,028,997...94,063,936 		JBrowse link
G Ces1h carboxylesterase 1H involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:94,078,468...94,106,405
Ensembl chr 8:94,078,471...94,106,353 		JBrowse link
G Stard4 StAR related lipid transfer domain containing 4 involved_in ISO GO_Central GO_REF:0000119 NCBI chr18:33,332,191...33,346,937
Ensembl chr18:33,332,408...33,346,915 		JBrowse link
regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP-binding cassette, sub-family A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 2:25,318,611...25,338,556
Ensembl chr 2:25,318,715...25,338,552 		JBrowse link
G Apob apolipoprotein B acts_upstream_of_or_within IMP (PMID:16455790) MGI PMID:16455790 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Aqp8 aquaporin 8 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 7:123,061,517...123,067,226
Ensembl chr 7:123,061,514...123,067,227 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO RGD
GO_Central		 PMID:10329655 GO_REF:0000096 RGD:632010 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr19:44,023,382...44,058,580
Ensembl chr19:44,023,383...44,058,224 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:27,513,399...27,529,465
Ensembl chr 8:27,513,289...27,530,356 		JBrowse link
G Gpr146 G protein-coupled receptor 146 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:139,363,452...139,382,170
Ensembl chr 5:139,363,452...139,382,170 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in IMP (PMID:29395055) UniProt PMID:29395055 NCBI chr 6:124,639,887...124,681,142
Ensembl chr 6:124,639,990...124,681,381 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within IMP (PMID:14673138) MGI PMID:14673138 NCBI chr 3:5,625,248...5,643,655
Ensembl chr 3:5,625,248...5,641,299 		JBrowse link
G Scap SREBF chaperone acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:16054043) MGI
GO_Central		 PMID:16054043 GO_REF:0000033 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018 		JBrowse link
regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in IMP (PMID:16556852) BHF-UCL PMID:16556852 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Acadl acyl-Coenzyme A dehydrogenase, long-chain involved_in IMP (PMID:15639194) BHF-UCL PMID:15639194 NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436 		JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain involved_in IMP (PMID:15639194) BHF-UCL PMID:15639194 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237 		JBrowse link
G Apoe apolipoprotein E involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator acts_upstream_of_or_within
involved_in		 IMP
ISS
ISO		 (PMID:20663892) MGI
UniProt
GO_Central		 PMID:20663892 GO_REF:0000024 GO_REF:0000119 NCBI chr 8:125,448,765...125,469,533
Ensembl chr 8:125,448,878...125,460,862 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 involved_in ISO RGD
GO_Central		 PMID:17526931 GO_REF:0000096 RGD:10400884 NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926 		JBrowse link
G Dgkq diacylglycerol kinase, theta involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 5:108,794,910...108,808,696
Ensembl chr 5:108,794,559...108,817,538 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic involved_in ISO
IMP		 (PMID:18974052) GO_Central
UniProt		 PMID:18974052 GO_REF:0000119 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Fmo5 flavin containing monooxygenase 5 involved_in IMP (PMID:26049045) UniProt PMID:26049045 NCBI chr 3:97,517,248...97,562,603
Ensembl chr 3:97,536,120...97,562,598 		JBrowse link
G Gnb3 guanine nucleotide binding protein (G protein), beta 3 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 6:124,811,203...124,817,238
Ensembl chr 6:124,811,203...124,817,238 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IGI (PMID:24412220) ARUK-UCL PMID:24412220 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lmf1 lipase maturation factor 1 acts_upstream_of_or_within IMP (PMID:6857276) MGI PMID:6857276 NCBI chr17:25,798,143...25,886,381
Ensembl chr17:25,798,059...25,881,800 		JBrowse link
G Por cytochrome p450 oxidoreductase involved_in ISO GO_Central GO_REF:0000096 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 acts_upstream_of_or_within IMP (PMID:22837305) MGI PMID:22837305 NCBI chr12:103,995,028...104,010,702
Ensembl chr12:103,995,028...104,010,702 		JBrowse link
G Thrb thyroid hormone receptor beta involved_in ISO RGD
GO_Central		 PMID:17878314 GO_REF:0000096 RGD:2315101 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B involved_in IBA
IMP		 (PMID:27383786) GO_Central
UniProt		 PMID:27383786 GO_REF:0000033 NCBI chr 4:83,138,537...83,242,488
Ensembl chr 4:83,138,537...83,242,492 		JBrowse link
G Ttc39d tetratricopeptide repeat domain 39D involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:80,523,343...80,525,365
Ensembl chr17:80,514,889...80,525,365 		JBrowse link
sterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ch25h cholesterol 25-hydroxylase involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr19:34,451,183...34,452,548
Ensembl chr19:34,451,178...34,452,564 		JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:134,333,519...134,339,476
Ensembl chr 1:134,333,297...134,339,478 		JBrowse link
G Cyb5r2 cytochrome b5 reductase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:107,347,653...107,357,407
Ensembl chr 7:107,347,662...107,357,239 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase acts_upstream_of_or_within IMP (PMID:15005800) MGI PMID:15005800 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Ebp EBP cholestenol delta-isomerase acts_upstream_of_or_within IMP
IC		 (PMID:10391218)
(PMID:8798407)		 MGI PMID:8798407 PMID:10391218 NCBI chr  X:8,051,568...8,059,751
Ensembl chr  X:8,051,568...8,059,751 		JBrowse link
G Erg28 ergosterol biosynthesis 28 involved_in IEA UniProt GO_REF:0000043 NCBI chr12:85,862,221...85,871,667
Ensembl chr12:85,862,222...85,871,324 		JBrowse link
G Faxdc2 fatty acid hydroxylase domain containing 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:57,954,508...57,983,977
Ensembl chr11:57,954,378...57,983,960 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Insig1 insulin induced gene 1 acts_upstream_of_or_within IGI (PMID:16955138) MGI PMID:16955138 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Insig2 insulin induced gene 2 acts_upstream_of_or_within IGI (PMID:16955138) MGI PMID:16955138 NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318 		JBrowse link
G Msmo1 methylsterol monoxygenase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in ISO GO_Central GO_REF:0000119 NCBI chr 3:89,361,848...89,376,321
Ensembl chr 3:89,361,848...89,376,320 		JBrowse link
G Sqle squalene epoxidase involved_in ISO
IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    cellular process 18389
      metabolic process 11662
        organic hydroxy compound metabolic process 608
          sterol metabolic process 177
            cholesterol metabolic process + 167
            ecdysone metabolic process + 0
            ergosterol metabolic process + 0
            sterol biosynthetic process + 79
            sterol catabolic process + 8
            zymosterol metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 28635
    cellular process 18389
      metabolic process 11662
        primary metabolic process 10275
          lipid metabolic process 1510
            steroid metabolic process 385
              sterol metabolic process 177
                cholesterol metabolic process + 167
                ecdysone metabolic process + 0
                ergosterol metabolic process + 0
                sterol biosynthetic process + 79
                sterol catabolic process + 8
                zymosterol metabolic process + 0
paths to the root