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ONTOLOGY REPORT - ANNOTATIONS

Term:sterol metabolic process
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Accession:GO:0016125 term browser browse the term
Definition:The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
Synonyms:exact_synonym: sterol metabolism

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sterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO (PMID:14684813) MGI PMID:14684813 NCBI chrNW_004955464:4,533,928...4,557,893
Ensembl chrNW_004955464:4,533,928...4,558,133 		JBrowse link
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO (PMID:21289032), (PMID:21697390), (PMID:25147230) RGD
MGI		 PMID:10419291 PMID:21289032 PMID:21697390 PMID:25147230 RGD:1626385 NCBI chrNW_004955425:3,718,291...3,755,942
Ensembl chrNW_004955425:3,718,206...3,756,142 		JBrowse link
G Lss lanosterol synthase ISO RGD PMID:16440058 RGD:1626611 NCBI chrNW_004955407:42,633,658...42,653,399
Ensembl chrNW_004955407:42,633,658...42,653,399 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 acts_upstream_of_or_within ISO (PMID:21289032), (PMID:21697390) MGI PMID:21289032 PMID:21697390 NCBI chrNW_004955402:11,699,434...11,742,899
Ensembl chrNW_004955402:11,699,434...11,742,899 		JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 acts_upstream_of_or_within ISO (PMID:21289032) MGI PMID:21289032 NCBI chrNW_004955523:1,010,976...1,021,048
Ensembl chrNW_004955523:1,010,976...1,021,144 		JBrowse link
cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 acts_upstream_of_or_within ISO (PMID:8647961) MGI PMID:8647961 NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298 		JBrowse link
G Cftr CF transmembrane conductance regulator acts_upstream_of_or_within ISO (PMID:17085523) MGI PMID:17085523 NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within
involved_in		 ISO (PMID:11519011)
(PMID:14684813)
(PMID:14684813), (PMID:16321981), (PMID:16513830)		 MGI
UniProt		 PMID:11519011 PMID:14684813 PMID:16321981 PMID:16513830 NCBI chrNW_004955464:4,533,928...4,557,893
Ensembl chrNW_004955464:4,533,928...4,558,133 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO (PMID:9465114) RGD
UniProt		 PMID:9465114 PMID:9831636 PMID:10329655 RGD:2316918 RGD:632010 NCBI chrNW_004955422:15,119,155...15,136,771
Ensembl chrNW_004955422:15,119,173...15,136,771 		JBrowse link
G Ebp EBP cholestenol delta-isomerase involved_in ISO (PMID:9894009) RGD
UniProt		 PMID:9894009 PMID:11171067 RGD:628445 NCBI chrNW_004955543:92,553...98,370
Ensembl chrNW_004955543:92,122...98,370 		JBrowse link
G Fdft1 farnesyl-diphosphate farnesyltransferase 1 ISO RGD PMID:16440058 RGD:1626611 NCBI chrNW_004955403:53,068,011...53,081,499
Ensembl chrNW_004955403:53,067,637...53,081,499 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase involved_in ISO (PMID:12027950) BHF-UCL PMID:12027950 NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in
acts_upstream_of_or_within		 ISO (PMID:23063590)
(PMID:15845870), (PMID:7798939), (PMID:8647961)		 CACAO
MGI		 PMID:7798939 PMID:8647961 PMID:15845870 PMID:23063590 NCBI chrNW_004955425:25,362,165...25,380,611
Ensembl chrNW_004955425:25,359,884...25,380,745 		JBrowse link
G Hsd17b7 hydroxysteroid 17-beta dehydrogenase 7 involved_in
acts_upstream_of_or_within		 ISO (PMID:12829805) UniProt
MGI		 PMID:12829805 NCBI chrNW_004955462:13,555,488...13,574,506
Ensembl chrNW_004955462:13,557,292...13,574,593 		JBrowse link
G Insig1 insulin induced gene 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:32322062)
(PMID:16955138)		 UniProt
MGI		 PMID:16955138 PMID:32322062 NCBI chrNW_004955491:8,333,624...8,344,658
Ensembl chrNW_004955491:8,335,359...8,344,658 		JBrowse link
G Insig2 insulin induced gene 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:32322062)
(PMID:16955138)		 UniProt
MGI		 PMID:16955138 PMID:32322062 NCBI chrNW_004955459:11,571,582...11,596,069
Ensembl chrNW_004955459:11,571,145...11,592,146 		JBrowse link
G Lbr lamin B receptor involved_in ISO (PMID:16784888)
(PMID:22140257)
(PMID:18785926)
(PMID:27336722)		 UniProt PMID:16784888 PMID:18785926 PMID:22140257 PMID:27336722 NCBI chrNW_004955520:401,733...418,279 JBrowse link
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO (PMID:25147230), (PMID:29599133) MGI PMID:25147230 PMID:29599133 NCBI chrNW_004955425:3,718,291...3,755,942
Ensembl chrNW_004955425:3,718,206...3,756,142 		JBrowse link
G Lss lanosterol synthase involved_in ISO PMID:7568116
(PMID:17186944)		 RGD
UniProt
BHF-UCL		 PMID:1429550 PMID:7568116 PMID:16440058 PMID:17186944 RGD:1626611 RGD:2316919 RGD:728996 NCBI chrNW_004955407:42,633,658...42,653,399
Ensembl chrNW_004955407:42,633,658...42,653,399 		JBrowse link
G Mvk mevalonate kinase involved_in ISO (PMID:1377680) UniProt PMID:1377680 NCBI chrNW_004955455:8,933,250...8,953,883
Ensembl chrNW_004955455:8,930,125...8,953,894 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO (PMID:17140581) HGNC-UCL PMID:17140581 NCBI chrNW_004955456:7,528,452...7,547,714
Ensembl chrNW_004955456:7,528,423...7,547,720 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in ISO (PMID:8663599) UniProt PMID:8663599 NCBI chrNW_004955545:1,421,562...1,440,038
Ensembl chrNW_004955545:1,421,562...1,440,038 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of ISO (PMID:9329978) MGI PMID:9329978 NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 involved_in ISO (PMID:16784888)
(PMID:18785926)		 UniProt PMID:16784888 PMID:18785926 NCBI chrNW_004955422:20,086,994...20,091,707
Ensembl chrNW_004955422:20,086,994...20,091,707 		JBrowse link
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102027002 lanosterol 14-alpha demethylase ISO RGD PMID:7581240 RGD:2316902 NCBI chrNW_004955432:9,092,923...9,112,615
Ensembl chrNW_004955432:9,092,933...9,112,615 		JBrowse link
cholesterol biosynthetic process via desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhcr24 24-dehydrocholesterol reductase involved_in ISO (PMID:11519011) UniProt PMID:11519011 NCBI chrNW_004955464:4,533,928...4,557,893
Ensembl chrNW_004955464:4,533,928...4,558,133 		JBrowse link
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhcr7 7-dehydrocholesterol reductase involved_in ISO (PMID:38297129), (PMID:38297130) UniProt PMID:38297129 PMID:38297130 NCBI chrNW_004955422:15,119,155...15,136,771
Ensembl chrNW_004955422:15,119,173...15,136,771 		JBrowse link
G Sc5d sterol-C5-desaturase involved_in ISO PMID:4019441
(PMID:10786622)		 RGD
UniProt		 PMID:4019441 PMID:7961720 PMID:10786622 RGD:2316911 RGD:405866208 NCBI chrNW_004955412:22,274,131...22,288,870
Ensembl chrNW_004955412:22,274,250...22,288,870 		JBrowse link
cholesterol catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1 member D1 involved_in ISO (PMID:7508385) UniProt PMID:7508385 NCBI chrNW_004955494:4,799,706...4,856,100
Ensembl chrNW_004955494:4,799,450...4,854,696 		JBrowse link
G Apoe apolipoprotein E acts_upstream_of_or_within ISO (PMID:9826706) MGI PMID:9826706 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 ISO RGD PMID:16081591 RGD:1599972 NCBI chrNW_004955493:7,835,160...7,838,428
Ensembl chrNW_004955493:7,835,160...7,838,428 		JBrowse link
G LOC102004889 sterol 26-hydroxylase, mitochondrial involved_in ISO (PMID:9660774) UniProt PMID:9660774 NCBI chrNW_004955453:14,601,495...14,647,383
Ensembl chrNW_004955453:14,601,444...14,647,366 		JBrowse link
G LOC102006164 24-hydroxycholesterol 7-alpha-hydroxylase acts_upstream_of_or_within ISO (PMID:10748047) MGI PMID:10748047 NCBI chrNW_004955437:11,444,780...11,497,268
Ensembl chrNW_004955437:11,444,220...11,497,084 		JBrowse link
G LOC102008593 cholesterol 7-alpha-monooxygenase involved_in
acts_upstream_of_or_within		 ISO PMID:1694852
(PMID:11279518), (PMID:15845870)		 UniProt
MGI		 PMID:1694852 PMID:11279518 PMID:15845870 RGD:70534 NCBI chrNW_004955454:17,035,105...17,078,854
Ensembl chrNW_004955454:17,036,204...17,042,756 		JBrowse link
G LOC102030124 cholesterol 24-hydroxylase involved_in ISO (PMID:14640697), (PMID:18621681), (PMID:25017465)
(PMID:10377398), (PMID:20193040)		 UniProt
ARUK-UCL		 PMID:10377398 PMID:14640697 PMID:18621681 PMID:20193040 PMID:25017465 NCBI chrNW_004955438:20,961,621...20,986,260
Ensembl chrNW_004955438:20,961,365...20,985,749 		JBrowse link
G Scarb1 scavenger receptor class B member 1 acts_upstream_of_or_within ISO (PMID:11278646)
(PMID:10559220)		 MGI PMID:10559220 PMID:11278646 NCBI chrNW_004955482:4,813,502...4,836,479
Ensembl chrNW_004955482:4,813,955...4,837,392 		JBrowse link
cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:14747463)
(PMID:11559713)		 BHF-UCL
MGI		 PMID:11559713 PMID:14747463 NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619 		JBrowse link
G Abca5 ATP binding cassette subfamily A member 5 involved_in ISO (PMID:25125465) UniProt PMID:25125465 NCBI chrNW_004955478:3,526,376...3,586,811
Ensembl chrNW_004955478:3,519,368...3,586,811 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:15994327) BHF-UCL PMID:15994327 NCBI chrNW_004955407:39,410,262...39,459,383
Ensembl chrNW_004955407:39,410,262...39,459,383 		JBrowse link
G Angptl3 angiopoietin like 3 involved_in ISO (PMID:17110602) BHF-UCL PMID:17110602 NCBI chrNW_004955423:27,113,378...27,121,339
Ensembl chrNW_004955423:27,109,962...27,121,276 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 acts_upstream_of_or_within ISO (PMID:17920016) MGI PMID:17920016 NCBI chrNW_004955412:31,043,320...31,075,617
Ensembl chrNW_004955412:31,043,320...31,075,617 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15464323)
(PMID:10357841), (PMID:15466405), (PMID:17071966), (PMID:7751823), (PMID:9327769), (PMID:9795222)
(PMID:15995171)		 BHF-UCL
MGI		 PMID:7751823 PMID:9327769 PMID:9795222 PMID:10357841 PMID:15464323 More... NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298 		JBrowse link
G Apoa2 apolipoprotein A2 acts_upstream_of_or_within ISO (PMID:10357838), (PMID:8647961) MGI PMID:8647961 PMID:10357838 NCBI chrNW_004955468:12,977,956...12,979,282
Ensembl chrNW_004955468:12,977,956...12,979,753 		JBrowse link
G Apoa4 apolipoprotein A4 involved_in ISO (PMID:1935934) BHF-UCL PMID:1935934 NCBI chrNW_004955412:18,158,095...18,160,636
Ensembl chrNW_004955412:18,155,801...18,160,701 		JBrowse link
G Apob apolipoprotein B involved_in ISO (PMID:2563166) BHF-UCL PMID:2563166 NCBI chrNW_004955469:3,437,422...3,478,408
Ensembl chrNW_004955469:3,436,450...3,478,424 		JBrowse link
G Apoc1 apolipoprotein C1 acts_upstream_of_or_within ISO (PMID:7848292) MGI PMID:7848292 NCBI chrNW_004955555:2,005,962...2,007,239 JBrowse link
G Apoc3 apolipoprotein C3 acts_upstream_of_or_within ISO (PMID:8864964)
(PMID:11590213), (PMID:8089130)		 MGI PMID:8089130 PMID:8864964 PMID:11590213 NCBI chrNW_004955412:18,165,667...18,168,015
Ensembl chrNW_004955412:18,165,667...18,168,015 		JBrowse link
G Apoe apolipoprotein E involved_in
acts_upstream_of_or_within		 ISO (PMID:9649566)
(PMID:1423598), (PMID:8647961)
(PMID:3771793)		 BHF-UCL
MGI		 PMID:1423598 PMID:3771793 PMID:8647961 PMID:9649566 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Apof apolipoprotein F acts_upstream_of_or_within ISO (PMID:22363685) MGI PMID:22363685 NCBI chrNW_004955458:3,973,734...3,978,312 JBrowse link
G App amyloid beta precursor protein acts_upstream_of_or_within ISO (PMID:17920016) MGI PMID:17920016 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268 		JBrowse link
G Cat catalase acts_upstream_of_or_within ISO (PMID:5087482) MGI PMID:5087482 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464 		JBrowse link
G Cebpa CCAAT enhancer binding protein alpha acts_upstream_of_or_within ISO (PMID:18974039) MGI PMID:18974039 NCBI chrNW_004955468:3,046,544...3,049,217
Ensembl chrNW_004955468:3,047,931...3,049,080 		JBrowse link
G Ch25h cholesterol 25-hydroxylase involved_in
acts_upstream_of_or_within		 ISO (PMID:33239446)
(PMID:9852097)		 UniProt
MGI		 PMID:9852097 PMID:33239446 NCBI chrNW_004955425:3,763,302...3,764,432 JBrowse link
G Cln6 CLN6 transmembrane ER protein involved_in ISO (PMID:16857350) UniProt PMID:16857350 NCBI chrNW_004955450:7,876,572...7,885,305
Ensembl chrNW_004955450:7,876,522...7,886,581 		JBrowse link
G Cln8 CLN8 transmembrane ER and ERGIC protein involved_in ISO (PMID:16086686) UniProt PMID:16086686 NCBI chrNW_004955403:57,926,711...57,938,698
Ensembl chrNW_004955403:57,924,873...57,938,690 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO (PMID:16407971) MGI PMID:16407971 NCBI chrNW_004955464:4,533,928...4,557,893
Ensembl chrNW_004955464:4,533,928...4,558,133 		JBrowse link
G Ebp EBP cholestenol delta-isomerase involved_in ISO (PMID:10391219) GO_Central PMID:10391219 NCBI chrNW_004955543:92,553...98,370
Ensembl chrNW_004955543:92,122...98,370 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 acts_upstream_of_or_within ISO (PMID:22912762)
(PMID:28053990)		 MGI PMID:22912762 PMID:28053990 NCBI chrNW_004955486:4,941,143...4,955,693
Ensembl chrNW_004955486:4,941,143...4,955,693 		JBrowse link
G Fdx1 ferredoxin 1 involved_in ISO (PMID:21636783) UniProt PMID:21636783 NCBI chrNW_004955412:12,280,900...12,312,930
Ensembl chrNW_004955412:12,286,408...12,316,707 		JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within ISO (PMID:11160364) MGI PMID:11160364 NCBI chrNW_004955402:41,902,868...41,938,099
Ensembl chrNW_004955402:41,902,868...41,938,174 		JBrowse link
G Fgl1 fibrinogen like 1 acts_upstream_of_or_within ISO (PMID:23483972) MGI PMID:23483972 NCBI chrNW_004955552:1,784,046...1,813,935
Ensembl chrNW_004955552:1,783,412...1,813,935 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:24211208), (PMID:26724485) UniProt PMID:24211208 PMID:26724485 NCBI chrNW_004955545:1,682,097...1,689,373
Ensembl chrNW_004955545:1,682,097...1,689,376 		JBrowse link
G Gba2 glucosylceramidase beta 2 involved_in ISO (PMID:26724485) UniProt PMID:26724485 NCBI chrNW_004955472:553,556...564,411
Ensembl chrNW_004955472:553,556...564,411 		JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO (PMID:11279518) MGI PMID:11279518 NCBI chrNW_004955455:10,694,102...10,717,613
Ensembl chrNW_004955455:10,694,102...10,717,613 		JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:11971948) UniProt PMID:11971948 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Insig1 insulin induced gene 1 acts_upstream_of_or_within ISO (PMID:16100574) MGI PMID:16100574 NCBI chrNW_004955491:8,333,624...8,344,658
Ensembl chrNW_004955491:8,335,359...8,344,658 		JBrowse link
G Insig2 insulin induced gene 2 acts_upstream_of_or_within ISO (PMID:16100574) MGI PMID:16100574 NCBI chrNW_004955459:11,571,582...11,596,069
Ensembl chrNW_004955459:11,571,145...11,592,146 		JBrowse link
G Lcat lecithin-cholesterol acyltransferase acts_upstream_of_or_within
involved_in		 ISO (PMID:9300780)
(PMID:26195816), (PMID:3458198), (PMID:4335615)
(PMID:10559507)		 RGD
MGI
BHF-UCL		 PMID:746355 PMID:3458198 PMID:4335615 PMID:9300780 PMID:10559507 More... RGD:1581789 NCBI chrNW_004955484:8,772,692...8,776,122
Ensembl chrNW_004955484:8,772,692...8,776,122 		JBrowse link
G Ldlr low density lipoprotein receptor acts_upstream_of_or_within ISO (PMID:17071966) MGI PMID:17071966 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056 		JBrowse link
G Lep leptin acts_upstream_of_or_within ISO (PMID:15995171) MGI PMID:15995171 NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472 		JBrowse link
G Lepr leptin receptor acts_upstream_of_or_within ISO (PMID:15995171) MGI PMID:15995171 NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407 		JBrowse link
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO (PMID:30639734)
(PMID:24370824)		 MGI PMID:24370824 PMID:30639734 NCBI chrNW_004955425:3,718,291...3,755,942
Ensembl chrNW_004955425:3,718,206...3,756,142 		JBrowse link
G Lipc lipase C, hepatic type acts_upstream_of_or_within ISO (PMID:10357838) MGI PMID:10357838 NCBI chrNW_004955450:15,947,869...16,062,449
Ensembl chrNW_004955450:15,948,187...16,048,766 		JBrowse link
G LOC102004889 sterol 26-hydroxylase, mitochondrial ISO RGD PMID:2175615 RGD:1299597 NCBI chrNW_004955453:14,601,495...14,647,383
Ensembl chrNW_004955453:14,601,444...14,647,366 		JBrowse link
G LOC102014960 cholesterol side-chain cleavage enzyme, mitochondrial involved_in ISO (PMID:18182448)
(PMID:21636783)		 UniProt PMID:18182448 PMID:21636783 NCBI chrNW_004955450:3,433,310...3,484,462
Ensembl chrNW_004955450:3,474,491...3,484,232 		JBrowse link
G Lrp1 LDL receptor related protein 1 acts_upstream_of_or_within ISO (PMID:17920016) MGI PMID:17920016 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146 		JBrowse link
G Lrp5 LDL receptor related protein 5 acts_upstream_of_or_within ISO (PMID:12509515) MGI PMID:12509515 NCBI chrNW_004955422:17,394,371...17,475,244
Ensembl chrNW_004955422:17,394,371...17,505,763 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like acts_upstream_of_or_within ISO (PMID:10369263) MGI PMID:10369263 NCBI chrNW_004955498:8,135,897...8,161,775
Ensembl chrNW_004955498:8,135,897...8,161,775 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 acts_upstream_of_or_within ISO (PMID:17242417) MGI PMID:17242417 NCBI chrNW_004955464:4,424,583...4,439,805
Ensembl chrNW_004955464:4,425,435...4,439,842 		JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 involved_in ISO (PMID:25035345) UniProt PMID:25035345 NCBI chrNW_004955550:1,275,921...1,279,262
Ensembl chrNW_004955550:1,275,921...1,279,270 		JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO (PMID:25429154) MGI PMID:25429154 NCBI chrNW_004955467:2,422,181...2,456,925
Ensembl chrNW_004955467:2,423,659...2,457,307 		JBrowse link
G Pon1 paraoxonase 1 acts_upstream_of_or_within ISO (PMID:9685159) MGI PMID:9685159 NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339 		JBrowse link
G Scap SREBF chaperone acts_upstream_of_or_within ISO (PMID:11358865) MGI PMID:11358865 NCBI chrNW_004955420:24,813,683...24,869,602
Ensembl chrNW_004955420:24,813,534...24,869,480 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 acts_upstream_of_or_within ISO (PMID:22383528) MGI PMID:22383528 NCBI chrNW_004955414:22,117,929...22,121,744
Ensembl chrNW_004955414:22,117,930...22,121,744 		JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:8407899)
(PMID:15845870)
(PMID:9756919)
(PMID:16647063)		 BHF-UCL
MGI		 PMID:8407899 PMID:9756919 PMID:15845870 PMID:16647063 NCBI chrNW_004955406:18,644,351...18,708,666
Ensembl chrNW_004955406:18,655,894...18,706,891 		JBrowse link
G Soat2 sterol O-acyltransferase 2 acts_upstream_of_or_within
involved_in		 ISO (PMID:9756919)
(PMID:11294643), (PMID:16647063)		 RGD
MGI
BHF-UCL		 PMID:9756919 PMID:11294643 PMID:12217884 PMID:16647063 RGD:625687 NCBI chrNW_004955458:383,123...394,003
Ensembl chrNW_004955458:382,892...394,749 		JBrowse link
G Sqle squalene epoxidase ISO RGD PMID:9300786 RGD:1625701 NCBI chrNW_004955461:121,886...143,389
Ensembl chrNW_004955461:122,528...143,064 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO RGD PMID:18071061 RGD:1643359 NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 involved_in ISO (PMID:28575648) UniProt PMID:28575648 NCBI chrNW_004955559:1,942,878...1,968,895 JBrowse link
G Tnfsf4 TNF superfamily member 4 acts_upstream_of_or_within ISO (PMID:3473481) MGI PMID:3473481 NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309 		JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan involved_in ISO (PMID:31391339) UniProt PMID:31391339 NCBI chrNW_004955414:15,166,349...15,178,284
Ensembl chrNW_004955414:15,166,349...15,178,284 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:1917954) RGD
BHF-UCL		 PMID:1917954 PMID:9225228 RGD:10059686 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G CUNH7orf50 chromosome unknown C7orf50 homolog involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004955460:8,714,109...8,839,162
Ensembl chrNW_004955460:8,712,187...8,839,187 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chrNW_004955507:6,029,247...6,062,946
Ensembl chrNW_004955507:6,028,324...6,063,689 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chrNW_004955463:13,445,468...13,460,370
Ensembl chrNW_004955463:13,444,722...13,463,132 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO (PMID:26311497) UniProt PMID:26311497 NCBI chrNW_004955491:8,333,624...8,344,658
Ensembl chrNW_004955491:8,335,359...8,344,658 		JBrowse link
negative regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ch25h cholesterol 25-hydroxylase involved_in ISO (PMID:29033131) UniProt PMID:29033131 NCBI chrNW_004955425:3,763,302...3,764,432 JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17916878) BHF-UCL PMID:17916878 NCBI chrNW_004955407:39,410,262...39,459,383
Ensembl chrNW_004955407:39,410,262...39,459,383 		JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in ISO (PMID:17916878) BHF-UCL PMID:17916878 NCBI chrNW_004955412:20,256,467...20,270,172
Ensembl chrNW_004955412:20,256,293...20,271,278 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO RGD PMID:18637708 RGD:2316295 NCBI chrNW_004955545:1,757,090...1,765,028
Ensembl chrNW_004955545:1,757,418...1,765,028 		JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISO (PMID:19229075) BHF-UCL PMID:19229075 NCBI chrNW_004955415:11,151,330...11,245,554
Ensembl chrNW_004955415:11,151,266...11,247,344 		JBrowse link
G Gnai1 G protein subunit alpha i1 involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004955410:5,388,184...5,467,022
Ensembl chrNW_004955410:5,388,184...5,467,022 		JBrowse link
G LOC102008593 cholesterol 7-alpha-monooxygenase involved_in ISO PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chrNW_004955454:17,035,105...17,078,854
Ensembl chrNW_004955454:17,036,204...17,042,756 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020 		JBrowse link
G Mbtps2 membrane bound transcription factor peptidase, site 2 involved_in ISO (PMID:11163209) UniProt PMID:11163209 NCBI chrNW_004955509:2,185,054...2,222,497
Ensembl chrNW_004955509:2,184,522...2,222,505 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO RGD PMID:32976883 RGD:405096663 NCBI chrNW_004955403:41,681,834...41,693,094
Ensembl chrNW_004955403:41,681,728...41,694,020 		JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 involved_in ISO (PMID:26311497) UniProt PMID:26311497 NCBI chrNW_004955433:3,323,426...3,350,358
Ensembl chrNW_004955433:3,321,625...3,350,588 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004955415:32,794,172...32,807,944
Ensembl chrNW_004955415:32,793,718...32,812,930 		JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISO (PMID:33942715) UniProt PMID:33942715 NCBI chrNW_004955439:17,925,205...18,079,727
Ensembl chrNW_004955439:17,925,229...18,079,727 		JBrowse link
G Scap SREBF chaperone involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chrNW_004955420:24,813,683...24,869,602
Ensembl chrNW_004955420:24,813,534...24,869,480 		JBrowse link
G Scp2 sterol carrier protein 2 ISO RGD PMID:2554812 RGD:9850260 NCBI chrNW_004955464:6,097,241...6,224,287
Ensembl chrNW_004955464:6,094,758...6,224,287 		JBrowse link
G Sec14l2 SEC14 like lipid binding 2 ISO RGD PMID:11226224 RGD:727312 NCBI chrNW_004955455:4,637,062...4,660,064
Ensembl chrNW_004955455:4,636,709...4,660,058 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:12177166), (PMID:32322062)
(PMID:8833906), (PMID:9062341)
(PMID:16046411)
(PMID:9329978)		 UniProt
MGI		 PMID:8833906 PMID:9062341 PMID:9329978 PMID:12177166 PMID:16046411 More... NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in ISO (PMID:12177166), (PMID:32322062), (PMID:38503280)
(PMID:33942715), (PMID:34021134)		 UniProt PMID:12177166 PMID:32322062 PMID:33942715 PMID:34021134 PMID:38503280 NCBI chrNW_004955413:27,271,717...27,326,655
Ensembl chrNW_004955413:27,271,953...27,326,759 		JBrowse link
positive regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 involved_in ISO (PMID:4335615) BHF-UCL PMID:4335615 NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:15654758) BHF-UCL PMID:15654758 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Stard4 StAR related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) BHF-UCL PMID:18403318 NCBI chrNW_004955418:3,637,390...3,652,054
Ensembl chrNW_004955418:3,638,399...3,648,402 		JBrowse link
regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
G Apob apolipoprotein B acts_upstream_of_or_within ISO (PMID:16455790) MGI PMID:16455790 NCBI chrNW_004955469:3,437,422...3,478,408
Ensembl chrNW_004955469:3,436,450...3,478,424 		JBrowse link
G Aqp8 aquaporin 8 involved_in ISO (PMID:30579780) UniProt PMID:30579780 NCBI chrNW_004955493:3,550,697...3,558,875
Ensembl chrNW_004955493:3,550,120...3,559,206 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase ISO RGD PMID:10329655 RGD:632010 NCBI chrNW_004955422:15,119,155...15,136,771
Ensembl chrNW_004955422:15,119,173...15,136,771 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) ComplexPortal PMID:24217618 NCBI chrNW_004955507:6,029,247...6,062,946
Ensembl chrNW_004955507:6,028,324...6,063,689 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) ComplexPortal PMID:24217618 NCBI chrNW_004955463:13,445,468...13,460,370
Ensembl chrNW_004955463:13,444,722...13,463,132 		JBrowse link
G Gpr146 G protein-coupled receptor 146 involved_in ISO (PMID:38503280) UniProt PMID:38503280 NCBI chrNW_004955460:8,747,499...8,762,141
Ensembl chrNW_004955460:8,759,661...8,760,704 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 involved_in ISO (PMID:29395055) UniProt PMID:29395055 NCBI chrNW_004955413:4,571,028...4,605,097
Ensembl chrNW_004955413:4,571,028...4,605,097 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (PMID:14673138) MGI PMID:14673138 NCBI chrNW_004955444:3,811,972...3,830,666
Ensembl chrNW_004955444:3,811,973...3,830,666 		JBrowse link
G Scap SREBF chaperone acts_upstream_of_or_within ISO (PMID:16054043) MGI PMID:16054043 NCBI chrNW_004955420:24,813,683...24,869,602
Ensembl chrNW_004955420:24,813,534...24,869,480 		JBrowse link
regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:16556852) BHF-UCL PMID:16556852 NCBI chrNW_004955407:39,410,262...39,459,383
Ensembl chrNW_004955407:39,410,262...39,459,383 		JBrowse link
G Acadl acyl-CoA dehydrogenase long chain involved_in ISO (PMID:15639194) BHF-UCL PMID:15639194 NCBI chrNW_004955457:5,266,032...5,300,632
Ensembl chrNW_004955457:5,266,033...5,300,056 		JBrowse link
G Acadvl acyl-CoA dehydrogenase very long chain involved_in ISO (PMID:15639194) BHF-UCL PMID:15639194 NCBI chrNW_004955467:9,684,070...9,689,454
Ensembl chrNW_004955467:9,684,250...9,689,356 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24412220) ARUK-UCL PMID:24412220 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator involved_in
acts_upstream_of_or_within		 ISO (PMID:20663892) UniProt
MGI		 PMID:20663892 NCBI chrNW_004955492:7,669,956...7,683,293
Ensembl chrNW_004955492:7,672,746...7,683,728 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 ISO RGD PMID:17526931 RGD:10400884 NCBI chrNW_004955414:16,059,781...16,089,727
Ensembl chrNW_004955414:16,059,781...16,089,727 		JBrowse link
G Dgkq diacylglycerol kinase theta involved_in ISO (PMID:24369117) ParkinsonsUK-UCL PMID:24369117 NCBI chrNW_004955514:452,548...475,240
Ensembl chrNW_004955514:453,886...464,978 		JBrowse link
G Ephx2 epoxide hydrolase 2 involved_in ISO (PMID:18974052) UniProt PMID:18974052 NCBI chrNW_004955403:49,999,563...50,038,800
Ensembl chrNW_004955403:49,999,563...50,041,572 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 involved_in ISO (PMID:26049045) UniProt PMID:26049045 NCBI chrNW_004955568:1,225,136...1,247,352
Ensembl chrNW_004955568:1,224,843...1,250,729 		JBrowse link
G Gnb3 G protein subunit beta 3 involved_in ISO (PMID:29206867) ARUK-UCL PMID:29206867 NCBI chrNW_004955413:4,440,693...4,447,419
Ensembl chrNW_004955413:4,440,693...4,447,416 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO (PMID:24412220) ARUK-UCL PMID:24412220 NCBI chrNW_004955495:2,114,702...2,135,584
Ensembl chrNW_004955495:2,114,434...2,138,056 		JBrowse link
G Lmf1 lipase maturation factor 1 acts_upstream_of_or_within ISO (PMID:6857276) MGI PMID:6857276 NCBI chrNW_004955442:16,250,131...16,360,907
Ensembl chrNW_004955442:16,245,081...16,360,846 		JBrowse link
G Serpina12 serpin family A member 12 acts_upstream_of_or_within ISO (PMID:22837305) MGI PMID:22837305 NCBI chrNW_004955438:17,826,596...17,849,341
Ensembl chrNW_004955438:17,833,919...17,849,393 		JBrowse link
G Thrb thyroid hormone receptor beta ISO RGD PMID:17878314 RGD:2315101 NCBI chrNW_004955430:15,992,146...16,322,696
Ensembl chrNW_004955430:15,992,146...16,323,238 		JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B involved_in ISO (PMID:27383786) UniProt PMID:27383786 NCBI chrNW_004955434:18,063,520...18,150,858
Ensembl chrNW_004955434:18,070,536...18,150,858 		JBrowse link
sterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhcr7 7-dehydrocholesterol reductase acts_upstream_of_or_within ISO (PMID:15005800) MGI PMID:15005800 NCBI chrNW_004955422:15,119,155...15,136,771
Ensembl chrNW_004955422:15,119,173...15,136,771 		JBrowse link
G Ebp EBP cholestenol delta-isomerase acts_upstream_of_or_within ISO (PMID:10391218) MGI PMID:10391218 NCBI chrNW_004955543:92,553...98,370
Ensembl chrNW_004955543:92,122...98,370 		JBrowse link
G Insig1 insulin induced gene 1 acts_upstream_of_or_within ISO (PMID:16955138) MGI PMID:16955138 NCBI chrNW_004955491:8,333,624...8,344,658
Ensembl chrNW_004955491:8,335,359...8,344,658 		JBrowse link
G Insig2 insulin induced gene 2 acts_upstream_of_or_within ISO (PMID:16955138) MGI PMID:16955138 NCBI chrNW_004955459:11,571,582...11,596,069
Ensembl chrNW_004955459:11,571,145...11,592,146 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in ISO (PMID:16519518) UniProt PMID:16519518 NCBI chrNW_004955545:1,421,562...1,440,038
Ensembl chrNW_004955545:1,421,562...1,440,038 		JBrowse link
G Sqle squalene epoxidase involved_in ISO (PMID:30626872) UniProt PMID:30626872 NCBI chrNW_004955461:121,886...143,389
Ensembl chrNW_004955461:122,528...143,064 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12572
    cellular process 12010
      metabolic process 7974
        organic hydroxy compound metabolic process 427
          sterol metabolic process 111
            cholesterol metabolic process + 109
            ecdysone metabolic process + 0
            ergosterol metabolic process + 0
            sterol biosynthetic process + 48
            sterol catabolic process + 8
            zymosterol metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 12572
    cellular process 12010
      metabolic process 7974
        primary metabolic process 7007
          lipid metabolic process 1002
            steroid metabolic process 239
              sterol metabolic process 111
                cholesterol metabolic process + 109
                ecdysone metabolic process + 0
                ergosterol metabolic process + 0
                sterol biosynthetic process + 48
                sterol catabolic process + 8
                zymosterol metabolic process + 0
paths to the root