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ONTOLOGY REPORT - ANNOTATIONS

Term:oxidoreduction-driven active transmembrane transporter activity
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Accession:GO:0015453 term browser browse the term
Definition:Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
Synonyms:exact_synonym: oxidoreduction-driven transporter
 xref: TC:3.D


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cytochrome-c oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox4i2 cytochrome c oxidase subunit 4i2 enables ISO
IEA		 (PMID:11311561)
GO_REF:0000107		 RGD
Ensembl		 PMID:11311561 GO_REF:0000107 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A IDA
TAS		 RGD PMID:7601105 PMID:2544858 RGD:727762, RGD:728245 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B TAS RGD PMID:8206867 RGD:728215 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052 		JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 TAS RGD PMID:8144025 RGD:727615 NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274 		JBrowse link
G Cox8b cytochrome c oxidase, subunit VIIIb TAS RGD PMID:8939982 RGD:727764 NCBI chr 1:195,977,183...195,978,643 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I contributes_to
enables		 ISO
IBA
ISS		 (PMID:12140182)
(PMID:18729827)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:12140182 PMID:18729827 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II contributes_to ISO
IBA
ISS		 (PMID:10486321)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:10486321 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Surf1 SURF1, cytochrome c oxidase assembly factor enables ISO MGI:2450930 (MGI:6393022|PMID:23838831), (PMID:12566387) RGD PMID:12566387 PMID:23838831 MGI:6393022 NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315 		JBrowse link
NADH dehydrogenase (ubiquinone) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 enables ISO
ISS		 (PMID:1959619)
GO_REF:0000024		 RGD
UniProt		 PMID:1959619 GO_REF:0000024 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 enables ISO
ISS
IBA		 (PMID:16996290)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:16996290 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942 		JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 enables ISO
ISS
IBA		 (PMID:25118196)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:25118196 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798 		JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 enables ISO
ISS		 (PMID:15250827), (PMID:8344246), (PMID:8644732)
GO_REF:0000024		 RGD
UniProt		 PMID:8344246 PMID:8644732 PMID:15250827 GO_REF:0000024 NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537 		JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L enables ISS
ISO		 GO_REF:0000024
(PMID:28844695), (PMID:29915388)		 UniProt
RGD		 PMID:28844695 PMID:29915388 GO_REF:0000024 NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166 		JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 enables
contributes_to		 ISO
ISS		 (PMID:15250827)
GO_REF:0000024
(PMID:18729827)		 RGD
UniProt		 PMID:15250827 PMID:18729827 GO_REF:0000024 NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565 		JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 enables ISS
ISO		 GO_REF:0000024
(PMID:14595656), (PMID:8644732)
(MGI:6508662|PMID:9707444)
(PMID:9707444)		 UniProt
RGD		 PMID:8644732 PMID:9707444 PMID:14595656 GO_REF:0000024 MGI:6508662 NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 enables ISO (PMID:24652937) RGD PMID:24652937 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 enables ISO (PMID:33502047) RGD PMID:33502047 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 contributes_to
enables		 ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:27799543), (PMID:32072193)
GO_REF:0000033
GO_REF:0000002
(MGI:6432573|PMID:32072193), (MGI:6478059|PMID:27799543)
(PMID:30879903), (PMID:31557978)
(PMID:15824269), (PMID:16478720), (PMID:16870178)		 UniProt
RGD
GO_Central
InterPro		 PMID:15824269 PMID:16478720 PMID:16870178 PMID:27799543 PMID:30879903 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 MGI:6432573 MGI:6478059 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 contributes_to
enables		 ISO
ISS
IMP		 (PMID:22036843), (PMID:30922174)
(PMID:26437605), (PMID:29887397), (PMID:31297047)
GO_REF:0000024
(PMID:28031252)
(MGI:6208149|PMID:29887397), (MGI:6220487|PMID:26437605), (MGI:6380745|PMID:31297047)		 RGD
UniProt		 PMID:22036843 PMID:26437605 PMID:28031252 PMID:29887397 PMID:30922174 More... GO_REF:0000024 MGI:6208149 MGI:6220487 MGI:6380745, RGD:42722001 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 enables
contributes_to		 ISO (MGI:6391555|PMID:31916679), (MGI:6505357|PMID:33148885)
(PMID:14729820)
(PMID:30140060)		 RGD PMID:14729820 PMID:30140060 PMID:31916679 PMID:33148885 MGI:6391555 MGI:6505357 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 contributes_to
enables		 ISO
IEA		 (PMID:15038602), (PMID:16870178)
MGI:3527173|MGI:3793713 (PMID:10747996), (PMID:18396137), (PMID:26712463), (PMID:29501746)
GO_REF:0000107
(PMID:16478720)		 RGD
Ensembl		 PMID:10747996 PMID:15038602 PMID:16478720 PMID:16870178 PMID:18396137 More... GO_REF:0000107 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 enables ISO
IBA		 (PMID:17275378)
GO_REF:0000033		 RGD
GO_Central		 PMID:17275378 GO_REF:0000033 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 contributes_to
enables		 ISO (PMID:9837812)
(PMID:22499348)		 RGD PMID:9837812 PMID:22499348 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 enables ISO (PMID:28844695)
(MGI:6730397|PMID:29915388)		 RGD PMID:28844695 PMID:29915388 MGI:6730397 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 contributes_to
enables		 ISO
ISS
IEA		 (PMID:12754703)
GO_REF:0000024
GO_REF:0000107
(PMID:28844695)
(MGI:6730397|PMID:29915388)
(PMID:29915388)		 RGD
UniProt
Ensembl		 PMID:12754703 PMID:28844695 PMID:29915388 GO_REF:0000024 GO_REF:0000107 MGI:6730397 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713 		JBrowse link
proton-translocating NAD(P)+ transhydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823 		JBrowse link
transmembrane ascorbate ferrireductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb561a3 cytochrome b561 family, member A3 enables ISS
ISO
IEA		 GO_REF:0000024
(MGI:6508497|PMID:16911521)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16911521 GO_REF:0000024 GO_REF:0000107 MGI:6508497 NCBI chr 1:207,216,185...207,237,575
Ensembl chr 1:207,226,230...207,237,571 		JBrowse link
G Cyb561d2 cytochrome b561 family, member D2 enables ISS
ISO		 GO_REF:0000024
(MGI:6202479|PMID:17938141)
(PMID:17938141)		 UniProt
RGD		 PMID:17938141 GO_REF:0000024 MGI:6202479 NCBI chr 8:108,213,201...108,215,778
Ensembl chr 8:108,213,205...108,215,759 		JBrowse link
G Cybrd1 cytochrome b reductase 1 enables ISO
ISS		 (PMID:17068337), (PMID:30272000)
GO_REF:0000024
(MGI:3697277|PMID:17068337)		 RGD
UniProt		 PMID:17068337 PMID:30272000 GO_REF:0000024 MGI:3697277 NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108 		JBrowse link
ubiquinol-cytochrome-c reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B TAS RGD PMID:7649306 RGD:633363 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249 		JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b enables
contributes_to		 ISO
IBA		 (PMID:22690928)
GO_REF:0000033		 RGD
GO_Central		 PMID:22690928 GO_REF:0000033 NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278 		JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 TAS RGD PMID:2538119 RGD:729966 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein enables ISS
ISO		 GO_REF:0000024
(PMID:34750991)		 UniProt
RGD		 PMID:34750991 GO_REF:0000024 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    transporter activity 1234
      transmembrane transporter activity 1136
        active transmembrane transporter activity 443
          primary active transmembrane transporter activity 151
            oxidoreduction-driven active transmembrane transporter activity 34
              NADH dehydrogenase (ubiquinone) activity 17
              cytochrome bo3 ubiquinol oxidase activity 0
              cytochrome-c oxidase activity 9
              plastoquinol--plastocyanin reductase activity 0
              proton-translocating NAD(P)+ transhydrogenase activity 1
              transmembrane ascorbate ferrireductase activity 3
              ubiquinol-cytochrome-c reductase activity 4
paths to the root