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ONTOLOGY REPORT - ANNOTATIONS

Term:potassium:chloride symporter activity
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Accession:GO:0015379 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
Synonyms:broad_synonym: potassium ion symporter activity
 alt_id: GO:0022820
 xref: RHEA:72427;   Reactome:R-HSA-5623806 "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region";   TC:2.A.30.1.5;   reactome:R-HSA-426155 "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region"


show annotations for term's descendants           Sort by:
potassium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a4 solute carrier family 12 member 4 enables IEA
ISO
ISS
IBA		 GO_REF:0000002
(PMID:34031912)
GO_REF:0000024
GO_REF:0000033
(PMID:11551954)
GO_REF:0000107		 InterPro
RGD
UniProt
GO_Central
Ensembl		 PMID:11551954 PMID:34031912 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr19:50,748,268...50,770,217
Ensembl chr19:33,838,419...33,860,331 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 enables IDA
ISO
IEA
IBA		 (PMID:12106695)
GO_REF:0000107
PMID:11551954
GO_REF:0000002
PMID:22544747
GO_REF:0000033
MGI:2181025 (PMID:11395011)		 RGD
Ensembl
InterPro
GO_Central		 PMID:11395011 PMID:12106695 PMID:12040048 PMID:10942735 PMID:15175220 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:628350, RGD:2303818, RGD:2303821, RGD:2303952, RGD:153298944, RGD:329845507 NCBI chr 3:174,115,833...174,155,112
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc12a6 solute carrier family 12, member 6 enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:10187864), (PMID:10600773), (PMID:11551954), (PMID:12657561), (PMID:16048901), (PMID:19665974), (PMID:34031912)
(PMID:10347194), (PMID:31649201)
GO_REF:0000002
GO_REF:0000107		 GO_Central
RGD
InterPro
Ensembl		 PMID:10187864 PMID:10347194 PMID:10600773 PMID:11551954 PMID:12657561 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:119,525,521...119,624,655
Ensembl chr 3:99,071,391...99,170,258 		JBrowse link
G Slc12a7 solute carrier family 12 member 7 enables TAS
ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000002
GO_REF:0000033
(PMID:11551954), (PMID:12106695), (PMID:12657561)		 UniProt
InterPro
GO_Central
RGD		 PMID:11551954 PMID:12106695 PMID:12657561 PMID:15533301 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033, RGD:1558104 NCBI chr 1:31,301,243...31,382,825
Ensembl chr 1:29,472,692...29,554,302 		JBrowse link
G Slc12a8 solute carrier family 12, member 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:80,622,000...80,771,674
Ensembl chr11:67,116,877...67,266,834 		JBrowse link
G Slc12a9 solute carrier family 12, member 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:25,005,741...25,022,628
Ensembl chr12:19,369,004...19,385,877 		JBrowse link
sodium:potassium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a1 solute carrier family 12 member 1 enables IDA
ISO
IBA
IEA		 (PMID:21321328)
GO_REF:0000033
(PMID:11790783)
GO_REF:0000117
GO_REF:0000107		 RGD
GO_Central
UniProt
Ensembl		 PMID:11790783 PMID:21321328 PMID:16291577 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1624189 NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 enables IMP
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000117
GO_REF:0000033
(PMID:33597714)		 Ensembl
UniProt
GO_Central
RGD		 PMID:33597714 PMID:12556450 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:1580435 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:10,636,594...10,690,008
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      transmembrane transporter activity 1165
        monoatomic ion transmembrane transporter activity 771
          monoatomic cation transmembrane transporter activity 652
            metal ion transmembrane transporter activity 464
              potassium ion transmembrane transporter activity 170
                potassium:chloride symporter activity 9
                  sodium:potassium:chloride symporter activity 3
Path 2
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      transmembrane transporter activity 1165
        active transmembrane transporter activity 449
          secondary active transmembrane transporter activity 294
            symporter activity 143
              solute:monoatomic cation symporter activity 117
                monoatomic anion:monoatomic cation symporter activity 26
                  chloride:monoatomic cation symporter activity 23
                    potassium:chloride symporter activity 9
                      sodium:potassium:chloride symporter activity 3
paths to the root