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ONTOLOGY REPORT - ANNOTATIONS

Term:sodium:chloride symporter activity
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Accession:GO:0015378 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in).
Synonyms:xref: Reactome:R-HSA-5623705 "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol";   reactome:R-HSA-426130 "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol"


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sodium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a3 solute carrier family 12 member 3 enables IMP
IDA
ISO
IEA		 PMID:10894798
(PMID:18270262), (PMID:36351028), (PMID:36792826)
(PMID:15068971)
GO_REF:0000117		 RGD
UniProt		 PMID:15068971 PMID:18270262 PMID:36351028 PMID:36792826 PMID:8021284 More... GO_REF:0000117, RGD:69999, RGD:1624221, RGD:155663524 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 enables ISO (PMID:10973981) RGD PMID:10973981 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
dopamine:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a1 solute carrier family 22 member 1 IDA RGD PMID:9776363 RGD:1643122 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 IDA RGD PMID:9830022 RGD:1643215 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 enables ISO
IBA		 (PMID:11093780), (PMID:8125921)
GO_REF:0000033		 RGD
GO_Central		 PMID:8125921 PMID:11093780 GO_REF:0000033 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 enables IDA
ISO
IMP		 MGI:2386303 (PMID:10375632), (PMID:9520487)
PMID:1948034
PMID:1502198
(PMID:10375632), (PMID:11093780), (PMID:1406597), (PMID:15505207), (PMID:19478460), (PMID:8302271)
PMID:8125921
PMID:1948035		 RGD PMID:1406597 PMID:8302271 PMID:9520487 PMID:10375632 PMID:11093780 More... RGD:730166, RGD:730247, RGD:152995550, RGD:152995566, RGD:730214, RGD:4139887 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
gamma-aminobutyric acid:sodium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a1 solute carrier family 6 member 1 enables IDA
ISO
IBA		 (PMID:16150932), (PMID:30270321), (PMID:8420981)
GO_REF:0000033
PMID:18054861
PMID:21775701
(PMID:10973981), (PMID:30132828)		 RGD
GO_Central		 PMID:8420981 PMID:10973981 PMID:16150932 PMID:30132828 PMID:30270321 More... GO_REF:0000033, RGD:632739, RGD:152025510, RGD:152025506 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slc6a11 solute carrier family 6 member 11 enables IDA
ISO
IBA		 (PMID:30270321), (PMID:8420981)
GO_REF:0000033
(PMID:7874447)
PMID:1497897		 RGD
GO_Central		 PMID:7874447 PMID:8420981 PMID:30270321 PMID:1400419 PMID:1497897 GO_REF:0000033, RGD:727560, RGD:729938 NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443 		JBrowse link
G Slc6a12 solute carrier family 6 member 12 enables TAS
ISO
IBA
ISS
IEA		 (PMID:1517200)
GO_REF:0000033
GO_REF:0000024
(PMID:10358010)
(PMID:7589472), (PMID:7861179)
GO_REF:0000002		 RGD
GO_Central
UniProt
InterPro		 PMID:1517200 PMID:7589472 PMID:7861179 PMID:10358010 PMID:15073174 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033, RGD:1303365 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750 		JBrowse link
G Slc6a13 solute carrier family 6 member 13 enables IDA
ISO
IBA
IEA		 (PMID:22896705), (PMID:30270321), (PMID:8420981)
GO_REF:0000033
(PMID:17502375), (PMID:22932902)
GO_REF:0000107
GO_REF:0000002		 RGD
GO_Central
Ensembl
InterPro		 PMID:8420981 PMID:17502375 PMID:22896705 PMID:22932902 PMID:30270321 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:727560, RGD:152025533 NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 enables IEA
ISO
IBA
IDA		 GO_REF:0000107
(PMID:30270321)
GO_REF:0000033
PMID:18501699		 Ensembl
RGD
GO_Central		 PMID:30270321 PMID:18501699 GO_REF:0000033 GO_REF:0000107, RGD:30309916 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875 		JBrowse link
G Slc6a8 solute carrier family 6 member 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:151,384,675...151,393,979
Ensembl chr  X:151,384,675...151,393,979 		JBrowse link
neutral L-amino acid:sodium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a18 solute carrier family 6 member 18 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19478081), (PMID:20377526), (PMID:26240152)		 UniProt
Ensembl
RGD		 PMID:19478081 PMID:20377526 PMID:26240152 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:29,607,288...29,621,925
Ensembl chr 1:29,608,077...29,621,925 		JBrowse link
norepinephrine:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a1 solute carrier family 22 member 1 IDA RGD PMID:9776363 RGD:1643122 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:16269905)
(PMID:2008212), (PMID:8125921)		 GO_Central
RGD		 PMID:2008212 PMID:8125921 PMID:16269905 PMID:10196144 GO_REF:0000033, RGD:634151 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 enables IDA PMID:8125921 UniProt PMID:8125921 RGD:152995566 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
serotonin:sodium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc18a1 solute carrier family 18 member A1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:16926160 GO_REF:0000033, RGD:5130998 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 enables TAS
ISO
IBA
IDA
IMP		 (PMID:9037532)
GO_REF:0000033
(PMID:10407194), (PMID:12869649), (PMID:17506858), (PMID:8987735)
PMID:1944572
PMID:15627510
PMID:8601815
PMID:10716733
PMID:11709063		 RGD
GO_Central		 PMID:8987735 PMID:9037532 PMID:10407194 PMID:12869649 PMID:17506858 More... GO_REF:0000033, RGD:730261, RGD:155663539, RGD:155663546, RGD:8553308, RGD:155663514, RGD:8554226, RGD:8553990, RGD:1580635 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
sodium:potassium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a1 solute carrier family 12 member 1 enables IDA
ISO
IBA
IEA		 (PMID:21321328)
GO_REF:0000033
(PMID:11790783)
GO_REF:0000117		 RGD
GO_Central
UniProt		 PMID:11790783 PMID:21321328 PMID:16291577 GO_REF:0000033 GO_REF:0000117, RGD:1624189 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 enables IMP
IBA
ISO		 GO_REF:0000033
(PMID:33597714)		 GO_Central
RGD		 PMID:33597714 PMID:12556450 GO_REF:0000033, RGD:1580435 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        monoatomic ion transmembrane transporter activity 770
          monoatomic anion transmembrane transporter activity 152
            monoatomic anion:monoatomic cation symporter activity 26
              monoatomic anion:sodium symporter activity 19
                sodium:chloride symporter activity 17
                  dopamine:sodium symporter activity 4
                  gamma-aminobutyric acid:sodium:chloride symporter activity 6
                  glycine betaine:sodium:chloride symporter activity 0
                  neutral L-amino acid:sodium:chloride symporter activity 1
                  norepinephrine:sodium symporter activity 3
                  serotonin:sodium:chloride symporter activity 3
                  sodium:potassium:chloride symporter activity 3
Path 2
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        monoatomic ion transmembrane transporter activity 770
          monoatomic cation transmembrane transporter activity 651
            metal ion transmembrane transporter activity 462
              sodium ion transmembrane transporter activity 174
                solute:sodium symporter activity 85
                  monoatomic anion:sodium symporter activity 19
                    sodium:chloride symporter activity 17
                      dopamine:sodium symporter activity 4
                      gamma-aminobutyric acid:sodium:chloride symporter activity 6
                      glycine betaine:sodium:chloride symporter activity 0
                      neutral L-amino acid:sodium:chloride symporter activity 1
                      norepinephrine:sodium symporter activity 3
                      serotonin:sodium:chloride symporter activity 3
                      sodium:potassium:chloride symporter activity 3
paths to the root