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ONTOLOGY REPORT - ANNOTATIONS

Term:methotrexate transmembrane transporter activity
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Accession:GO:0015350 term browser browse the term
Definition:Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
Synonyms:related_synonym: methotrexate transporter activity


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methotrexate transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc19a1 solute carrier family 19 member 1 enables IDA
ISO		 PMID:10827155
(PMID:22554803)
(PMID:9748272)		 RGD PMID:9748272 PMID:22554803 PMID:10827155 RGD:14929207 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 enables ISS
ISO		 GO_REF:0000024
(PMID:17962486)		 UniProt
RGD		 PMID:17962486 GO_REF:0000024 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        amide transmembrane transporter activity 39
          methotrexate transmembrane transporter activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        organic acid transmembrane transporter activity 193
          carboxylic acid transmembrane transporter activity 192
            dicarboxylic acid transmembrane transporter activity 31
              methotrexate transmembrane transporter activity 2
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