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ONTOLOGY REPORT - ANNOTATIONS

Term:proton channel activity
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Accession:GO:0015252 term browser browse the term
Definition:Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Synonyms:exact_synonym: hydrogen ion channel activity
 xref: Reactome:R-HSA-9729542 "OTOP1 transports H+ from the extracellular region to the cytosol"


show annotations for term's descendants           Sort by:
proton channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic5 acid sensing ion channel subunit family member 5 enables ISO
IEA		 (PMID:20656685)
GO_REF:0000107		 RGD
Ensembl		 PMID:20656685 GO_REF:0000107 NCBI chr 2:169,606,059...169,634,885
Ensembl chr 2:167,307,984...167,336,812 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 enables ISS
ISO		 GO_REF:0000024
(PMID:37244256)		 UniProt
RGD		 PMID:37244256 GO_REF:0000024 NCBI chr10:81,520,762...81,523,735
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:37244256)		 UniProt
Ensembl
RGD		 PMID:37244256 GO_REF:0000024 GO_REF:0000107 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Otop1 otopetrin 1 enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000117
GO_REF:0000002
GO_REF:0000033
(PMID:29371428)
(PMID:29371428), (PMID:36266567)		 UniProt
Ensembl
InterPro
GO_Central
RGD		 PMID:29371428 PMID:36266567 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr14:76,717,330...76,744,785
Ensembl chr14:72,503,592...72,532,497 		JBrowse link
G Otop2 otopetrin 2 enables ISO
IEA
IBA		 (PMID:29371428)
GO_REF:0000117
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
InterPro
Ensembl
GO_Central		 PMID:29371428 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr10:100,564,727...100,574,298
Ensembl chr10:100,564,727...100,574,298 		JBrowse link
G Otop3 otopetrin 3 enables ISO
IEA
IBA		 (PMID:29371428)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
GO_REF:0000033		 RGD
Ensembl
InterPro
UniProt
GO_Central		 PMID:29371428 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr10:100,577,346...100,588,729
Ensembl chr10:100,577,392...100,588,726 		JBrowse link
G Slc4a11 solute carrier family 4 member 11 enables ISO
IEA		 (PMID:15525507)
GO_REF:0000107		 RGD
Ensembl		 PMID:15525507 GO_REF:0000107 NCBI chr 3:117,900,223...117,912,787
Ensembl chr 3:117,900,223...117,912,674 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:37535724)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:37535724 GO_REF:0000024 GO_REF:0000107 NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
G Tmem175 transmembrane protein 175 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:35333573), (PMID:35750034), (PMID:37390818)
GO_REF:0000002		 UniProt
Ensembl
RGD
InterPro		 PMID:35333573 PMID:35750034 PMID:37390818 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr14:1,217,911...1,234,236
Ensembl chr14:1,073,523...1,089,819 		JBrowse link
proton-transporting ATP synthase activity, rotational mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07025819.1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr16:48,628,407...48,628,892 JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha contributes_to
enables		 ISO
IEA
IBA		 (PMID:12110673)
(PMID:21106936)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:17612527)		 RGD
Ensembl
InterPro
GO_Central		 PMID:12110673 PMID:17612527 PMID:21106936 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta contributes_to
enables		 ISO
ISS
IBA
IDA
IEA		 (PMID:12110673)
GO_REF:0000024
GO_REF:0000033
PMID:9736690
(PMID:21106936), (PMID:25168243), (PMID:36239646)
(PMID:21281446)
GO_REF:0000002
GO_REF:0000107		 RGD
UniProt
GO_Central
InterPro
Ensembl		 PMID:12110673 PMID:21106936 PMID:21281446 PMID:25168243 PMID:36239646 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:596936199 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma enables
contributes_to		 IEA
ISO
IBA		 GO_REF:0000002
(PMID:12110673)
GO_REF:0000033		 InterPro
RGD
GO_Central		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 NCBI chr17:73,333,584...73,355,872
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta contributes_to
enables		 ISO
IEA
IBA		 (PMID:12110673)
GO_REF:0000002
GO_REF:0000033
GO_REF:0000107		 RGD
InterPro
GO_Central
Ensembl		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:10,211,260...10,218,989
Ensembl chr 7:9,560,608...9,565,929 		JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon contributes_to
enables		 ISO
IEA
IBA		 (PMID:12110673)
GO_REF:0000002
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:163,260,476...163,261,450 		JBrowse link
G Atp5hl1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d-like 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:55,360,802...55,361,401
Ensembl chr16:48,628,407...48,628,892 		JBrowse link
G Atp5me ATP synthase membrane subunit e contributes_to ISO
IEA		 (PMID:12110673)
GO_REF:0000107		 RGD
Ensembl		 PMID:12110673 GO_REF:0000107 NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,319,868...1,321,013 		JBrowse link
G Atp5mf ATP synthase membrane subunit f contributes_to ISO
IBA		 (PMID:12110673)
GO_REF:0000033		 RGD
GO_Central		 PMID:12110673 GO_REF:0000033 NCBI chr12:14,535,435...14,542,007
Ensembl chr12:9,421,579...9,428,236 		JBrowse link
G Atp5mg ATP synthase membrane subunit G contributes_to ISO
IBA		 (PMID:12110673)
GO_REF:0000033		 RGD
GO_Central		 PMID:12110673 GO_REF:0000033 NCBI chr 8:54,122,457...54,130,407
Ensembl chr 8:45,225,686...45,233,559 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b contributes_to ISO
IBA
IEA		 (PMID:12110673)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:12110673 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:193,424,047...193,435,418 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d contributes_to ISO
IBA		 (PMID:12110673)
GO_REF:0000033		 RGD
GO_Central		 PMID:12110673 GO_REF:0000033 NCBI chr10:101,156,673...101,161,926
Ensembl chr10:100,657,708...100,663,479 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 contributes_to ISO (PMID:12110673) RGD PMID:12110673 NCBI chr11:37,368,045...37,375,721
Ensembl chr11:23,881,592...23,889,119 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP contributes_to
enables		 ISO
IBA
IEA		 (PMID:12110673)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002		 RGD
GO_Central
Ensembl
InterPro		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr11:44,651,171...44,657,483
Ensembl chr11:31,165,217...31,171,592 		JBrowse link
G LOC100361879 ATP synthase subunit epsilon, mitochondrial-like enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:82,087,509...82,088,367
Ensembl chr14:77,863,571...77,863,729 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 contributes_to ISO
IBA
IEA		 (PMID:12110673)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:12110673 GO_REF:0000033 GO_REF:0000107 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 contributes_to ISO (PMID:12110673) RGD PMID:12110673 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961 		JBrowse link
G Taf3 TATA-box binding protein associated factor 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:73,365,162...73,518,053
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
voltage-gated proton channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cybb cytochrome b-245 beta chain NOT|enables ISO (PMID:11477065), (PMID:12034764) RGD PMID:11477065 PMID:12034764 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 enables IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000002
(PMID:16556803), (PMID:22569364)
(PMID:16554753), (PMID:20548053), (PMID:22020278), (PMID:27859356), (PMID:30478045)		 GO_Central
InterPro
RGD		 PMID:16554753 PMID:16556803 PMID:20548053 PMID:22020278 PMID:22569364 More... GO_REF:0000002 GO_REF:0000033 NCBI chr12:40,001,205...40,030,671
Ensembl chr12:34,335,190...34,370,141 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21102
    transporter activity 1395
      transmembrane transporter activity 1278
        monoatomic ion transmembrane transporter activity 881
          monoatomic ion channel activity 573
            monoatomic cation channel activity 453
              proton channel activity 28
                proton-transporting ATP synthase activity, rotational mechanism 18
                voltage-gated proton channel activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21102
    transporter activity 1395
      transmembrane transporter activity 1278
        passive transmembrane transporter activity 637
          channel activity 637
            monoatomic ion channel activity 573
              monoatomic cation channel activity 453
                proton channel activity 28
                  proton-transporting ATP synthase activity, rotational mechanism 18
                  voltage-gated proton channel activity 2
paths to the root