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ONTOLOGY REPORT - ANNOTATIONS

Term:proton channel activity
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Accession:GO:0015252 term browser browse the term
Definition:Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Synonyms:exact_synonym: hydrogen ion channel activity
 xref: Reactome:R-HSA-9729542 "OTOP1 transports H+ from the extracellular region to the cytosol"


show annotations for term's descendants           Sort by:
proton channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic5 acid sensing ion channel subunit family member 5 enables IEA
ISO 		GO_REF:0000107
(PMID:20656685) 		Ensembl
RGD		 PMID:20656685 GO_REF:0000107 NCBI chr 2:169,606,059...169,634,885
Ensembl chr 2:169,606,059...169,634,885 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 enables ISS
ISO 		GO_REF:0000024
(PMID:37244256) 		UniProt
RGD		 PMID:37244256 GO_REF:0000024 NCBI chr10:81,520,762...81,523,735
Ensembl chr10:81,520,765...81,523,363 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 enables ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:37244256) 		UniProt
Ensembl
RGD		 PMID:37244256 GO_REF:0000024 GO_REF:0000107 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,904...8,584 		JBrowse link
G Otop1 otopetrin 1 enables ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:29371428)
GO_REF:0000107
GO_REF:0000117
GO_REF:0000002
GO_REF:0000033
(PMID:29371428), (PMID:36266567) 		UniProt
RGD
Ensembl
InterPro
GO_Central		 PMID:29371428 PMID:36266567 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr14:76,717,330...76,744,785
Ensembl chr14:76,716,329...76,744,785 		JBrowse link
G Otop2 otopetrin 2 enables IBA
ISO
IEA 		GO_REF:0000033
(PMID:29371428)
GO_REF:0000117
GO_REF:0000002
GO_REF:0000107 		GO_Central
RGD
UniProt
InterPro
Ensembl		 PMID:29371428 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr10:101,063,701...101,073,271
Ensembl chr10:101,063,701...101,073,271 		JBrowse link
G Otop3 otopetrin 3 enables IBA
ISO
IEA 		GO_REF:0000033
(PMID:29371428)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117 		GO_Central
RGD
Ensembl
InterPro
UniProt		 PMID:29371428 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr10:101,076,307...101,087,704
Ensembl chr10:101,076,210...101,087,697 		JBrowse link
G Slc4a11 solute carrier family 4 member 11 enables ISO
IEA 		(PMID:15525507)
GO_REF:0000107 		RGD
Ensembl		 PMID:15525507 GO_REF:0000107 NCBI chr 3:138,353,305...138,365,983
Ensembl chr 3:138,353,305...138,365,754 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 enables ISO (PMID:40280132) RGD PMID:40280132 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 enables ISS
ISO
IEA 		GO_REF:0000024
(PMID:37535724)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:37535724 GO_REF:0000024 GO_REF:0000107 NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,606,196...27,611,947 		JBrowse link
G Tmem175 transmembrane protein 175 enables ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:35333573), (PMID:35750034), (PMID:37390818)
GO_REF:0000002 		UniProt
Ensembl
RGD
InterPro		 PMID:35333573 PMID:35750034 PMID:37390818 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr14:1,217,911...1,234,236
Ensembl chr14:1,217,914...1,234,018 		JBrowse link
proton-transporting ATP synthase activity, rotational mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5f1a ATP synthase F1 subunit alpha contributes_to
enables 		ISO
IEA
IBA 		(PMID:12110673)
(PMID:21106936)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:17612527) 		RGD
Ensembl
InterPro
GO_Central		 PMID:12110673 PMID:17612527 PMID:21106936 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta contributes_to
enables 		ISO
ISS
IDA
IEA 		(PMID:12110673)
GO_REF:0000024
PMID:9736690
(PMID:21106936), (PMID:25168243), (PMID:36239646)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000117
(PMID:21281446) 		RGD
UniProt
InterPro
Ensembl		 PMID:12110673 PMID:21106936 PMID:21281446 PMID:25168243 PMID:36239646 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 GO_REF:0000117, RGD:596936199 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462 		JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma enables
contributes_to 		IEA
ISO
IBA 		GO_REF:0000002
(PMID:12110673)
GO_REF:0000033 		InterPro
RGD
GO_Central		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta contributes_to
enables 		ISO
IEA
IBA 		(PMID:12110673)
GO_REF:0000002
GO_REF:0000033
GO_REF:0000107 		RGD
InterPro
GO_Central
Ensembl		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:10,211,260...10,218,989
Ensembl chr 7:10,211,262...10,216,583 		JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon contributes_to
enables 		ISO
IEA
IBA 		(PMID:12110673)
GO_REF:0000002
GO_REF:0000033 		RGD
InterPro
GO_Central		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214 		JBrowse link
G Atp5me ATP synthase membrane subunit e contributes_to ISO
IEA 		(PMID:12110673)
GO_REF:0000107 		RGD
Ensembl		 PMID:12110673 GO_REF:0000107 NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,464,800...1,465,988 		JBrowse link
G Atp5mf ATP synthase membrane subunit f contributes_to ISO
IBA 		(PMID:12110673)
GO_REF:0000033 		RGD
GO_Central		 PMID:12110673 GO_REF:0000033 NCBI chr12:14,535,435...14,542,007
Ensembl chr12:14,522,832...14,542,709 		JBrowse link
G Atp5mg ATP synthase membrane subunit G contributes_to ISO
IBA 		(PMID:12110673)
GO_REF:0000033 		RGD
GO_Central		 PMID:12110673 GO_REF:0000033 NCBI chr 8:54,122,457...54,130,407
Ensembl chr 8:54,122,457...54,132,831 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b contributes_to ISO
IBA
IEA 		(PMID:12110673)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:12110673 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:196,112,108...196,124,387 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d contributes_to ISO
IBA 		(PMID:12110673)
GO_REF:0000033 		RGD
GO_Central		 PMID:12110673 GO_REF:0000033 NCBI chr10:101,156,673...101,161,926
Ensembl chr10:101,156,673...101,162,954 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 contributes_to ISO (PMID:12110673) RGD PMID:12110673 NCBI chr11:37,368,045...37,375,721
Ensembl chr11:37,368,042...37,375,466 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP contributes_to
enables 		ISO
IBA
IEA 		(PMID:12110673)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002 		RGD
GO_Central
Ensembl
InterPro		 PMID:12110673 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr11:44,651,171...44,657,483
Ensembl chr11:44,651,173...44,657,520 		JBrowse link
G LOC100361879 ATP synthase subunit epsilon, mitochondrial-like enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:82,087,509...82,088,367
Ensembl chr14:82,088,047...82,088,205 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 contributes_to ISO
IBA
IEA 		(PMID:12110673)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:12110673 GO_REF:0000033 GO_REF:0000107 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,904...8,584 		JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 contributes_to ISO (PMID:12110673) RGD PMID:12110673 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,743...7,946 		JBrowse link
G Taf3 TATA-box binding protein associated factor 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:73,365,162...73,518,053 JBrowse link
voltage-gated proton channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cybb cytochrome b-245 beta chain NOT|enables ISO (PMID:11477065), (PMID:12034764) RGD PMID:11477065 PMID:12034764 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 enables IBA
ISO
IEA 		GO_REF:0000033
(PMID:16556803)
(PMID:22569364)
GO_REF:0000117
GO_REF:0000002
(PMID:16554753), (PMID:20548053), (PMID:22020278), (PMID:27859356), (PMID:30478045) 		GO_Central
RGD
UniProt
InterPro		 PMID:16554753 PMID:16556803 PMID:20548053 PMID:22020278 PMID:22569364 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 NCBI chr12:40,001,205...40,030,671
Ensembl chr12:40,001,498...40,042,020 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19971
    transporter activity 1257
      transmembrane transporter activity 1138
        monoatomic ion transmembrane transporter activity 757
          monoatomic ion channel activity 450
            monoatomic cation channel activity 346
              proton channel activity 27
                proton-transporting ATP synthase activity, rotational mechanism 16
                voltage-gated proton channel activity 2
Path 2
Term Annotations click to browse term
  molecular_function 19971
    transporter activity 1257
      transmembrane transporter activity 1138
        passive transmembrane transporter activity 514
          channel activity 514
            monoatomic ion channel activity 450
              monoatomic cation channel activity 346
                proton channel activity 27
                  proton-transporting ATP synthase activity, rotational mechanism 16
                  voltage-gated proton channel activity 2
paths to the root