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ONTOLOGY REPORT - ANNOTATIONS

Term:choline transmembrane transporter activity
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Accession:GO:0015220 term browser browse the term
Definition:Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
Synonyms:exact_synonym: choline permease activity
 narrow_synonym: amino acid/choline transmembrane transporter activity
 alt_id: GO:0005306
 xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol";   reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol";   reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol";   reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix"


show annotations for term's descendants           Sort by:
choline transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flvcr1 FLVCR choline and heme transporter 1 enables IEA
ISO 		GO_REF:0000107
(PMID:37100056), (PMID:38693265), (PMID:38778100), (PMID:39306721) 		Ensembl
RGD		 PMID:37100056 PMID:38693265 PMID:38778100 PMID:39306721 GO_REF:0000107 NCBI chr13:105,117,402...105,139,780
Ensembl chr13:105,117,402...105,139,759 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 enables ISS
ISO
IEA 		GO_REF:0000024
(PMID:38302740), (PMID:38778100)
GO_REF:0000117
(PMID:38302740), (PMID:38693257) 		UniProt
RGD		 PMID:38302740 PMID:38693257 PMID:38778100 GO_REF:0000024 GO_REF:0000117 NCBI chr 6:111,139,352...111,203,345
Ensembl chr 6:111,139,295...111,203,345 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 enables IDA
ISO
IEA 		(PMID:9687576)
GO_REF:0000107 		RGD
Ensembl		 PMID:9687576 PMID:11553644 GO_REF:0000107, RGD:628453 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc25a48 solute carrier family 25, member 48 enables ISO (PMID:38977856), (PMID:39084256) RGD PMID:38977856 PMID:39084256 NCBI chr17:8,113,134...8,172,376
Ensembl chr17:8,127,111...8,166,042 		JBrowse link
G Slc44a1 solute carrier family 44 member 1 enables ISS
IMP
ISO
IEA
IBA 		GO_REF:0000024
PMID:19519661
(PMID:16319125), (PMID:19357133), (PMID:20410607), (PMID:23651124), (PMID:31855247), (PMID:33789160)
GO_REF:0000107
GO_REF:0000033
(PMID:15474312), (PMID:19519661) 		UniProt
RGD
Ensembl
GO_Central		 PMID:15474312 PMID:16319125 PMID:19357133 PMID:19519661 PMID:20410607 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:15090833 NCBI chr 5:72,857,323...73,037,279
Ensembl chr 5:72,858,759...73,037,279 		JBrowse link
G Slc44a2 solute carrier family 44 member 2 NOT|enables ISO
ISS
IEA 		(PMID:10677542), (PMID:20665236)
(PMID:20410607), (PMID:23651124), (PMID:33789160)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:10677542 PMID:20410607 PMID:20665236 PMID:23651124 PMID:33789160 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:28,147,023...28,181,496
Ensembl chr 8:28,147,030...28,181,495 		JBrowse link
G Slc44a4 solute carrier family 44, member 4 enables ISS
ISO
IEA 		GO_REF:0000024
(PMID:23651124), (PMID:28013291)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:23651124 PMID:28013291 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,907,737...3,923,911
Ensembl chr20:3,907,737...3,923,854 		JBrowse link
G Slc44a5 solute carrier family 44, member 5 enables ISO
IEA 		(PMID:23651124)
GO_REF:0000107 		RGD
Ensembl		 PMID:23651124 GO_REF:0000107 NCBI chr 2:245,570,875...245,866,369
Ensembl chr 2:245,570,829...245,867,780 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 enables IMP
ISO
IDA
IEA 		PMID:10649566
(PMID:11027560), (PMID:11068039), (PMID:12237312), (PMID:12969261), (PMID:17005849), (PMID:23132865), (PMID:23141292), (PMID:27569547)
GO_REF:0000117
GO_REF:0000107
(PMID:11709061), (PMID:15173594), (PMID:17196556) 		RGD
UniProt
Ensembl		 PMID:11027560 PMID:11068039 PMID:11709061 PMID:12237312 PMID:12969261 More... GO_REF:0000107 GO_REF:0000117, RGD:68853, RGD:68853 NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,922,697...7,953,509 		JBrowse link
G Slc6a8 solute carrier family 6 member 8 NAS
IDA 		RGD PMID:8297374 PMID:1633856 RGD:634748, RGD:737698 NCBI chr  X:156,536,017...156,545,321
Ensembl chr  X:156,536,017...156,545,321 		JBrowse link
choline:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc5a7 solute carrier family 5 member 7 enables ISO
IBA
ISS 		(PMID:11068039), (PMID:12237312), (PMID:17005849)
GO_REF:0000033
GO_REF:0000024 		RGD
GO_Central
UniProt		 PMID:11068039 PMID:12237312 PMID:17005849 GO_REF:0000024 GO_REF:0000033 NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,922,697...7,953,509 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19971
    transporter activity 1257
      transmembrane transporter activity 1138
        choline transmembrane transporter activity 10
          ABC-type choline transporter activity 0
          choline:sodium symporter activity 1
paths to the root