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ONTOLOGY REPORT - ANNOTATIONS

Term:lactate transmembrane transporter activity
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Accession:GO:0015129 term browser browse the term
Definition:Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
Synonyms:related_synonym: monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
 xref: reactome:R-HSA-373867 "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol";   reactome:R-HSA-373875 "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region"


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lactate transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc16a1 solute carrier family 16 member 1 enables ISO (PMID:29026134) RGD PMID:29026134 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 enables ISO MGI:6467009 (PMID:31837519) RGD PMID:31837519 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562 		JBrowse link
G Slc16a7 solute carrier family 16 member 7 enables ISO
IBA
ISS		 (PMID:9786900)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:9786900 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994 		JBrowse link
G Slc5a12 solute carrier family 5 member 12 enables IBA
ISO		 GO_REF:0000033
(PMID:16104846)		 GO_Central
RGD		 PMID:16104846 GO_REF:0000033 NCBI chr 3:97,179,326...97,228,405
Ensembl chr 3:97,179,326...97,228,405 		JBrowse link
G Slc5a8 solute carrier family 5 member 8 enables ISO (PMID:15322102) RGD PMID:15322102 NCBI chr 7:23,272,891...23,313,811
Ensembl chr 7:23,272,427...23,314,642 		JBrowse link
lactate:proton symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc16a1 solute carrier family 16 member 1 enables IDA
ISO
IBA		 PMID:9639576
(PMID:12946269)
GO_REF:0000033		 RGD
GO_Central		 PMID:12946269 PMID:9639576 GO_REF:0000033, RGD:155230795 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 enables ISO
IDA
IEA
IBA		 (PMID:11101640)
PMID:10926847
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:11101640 PMID:10926847 GO_REF:0000033 GO_REF:0000107, RGD:152995558 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    transporter activity 1253
      transmembrane transporter activity 1153
        organic hydroxy compound transmembrane transporter activity 53
          lactate transmembrane transporter activity 5
            lactate:proton symporter activity 2
Path 2
Term Annotations click to browse term
  molecular_function 20633
    transporter activity 1253
      transmembrane transporter activity 1153
        organic acid transmembrane transporter activity 189
          carboxylic acid transmembrane transporter activity 188
            monocarboxylic acid transmembrane transporter activity 73
              lactate transmembrane transporter activity 5
                lactate:proton symporter activity 2
paths to the root