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ONTOLOGY REPORT - ANNOTATIONS

Term:muscle hypertrophy
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Accession:GO:0014896 term browser browse the term
Definition:The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.
Synonyms:xref: Wikipedia:Muscle_hypertrophy


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muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 (PMID:10191278)
GO_REF:0000107		 RGD
Ensembl		 PMID:10191278 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang2 angiogenin, ribonuclease A family, member 2 acts_upstream_of_or_within ISO (PMID:29065170) RGD PMID:29065170 NCBI chr15:26,871,842...26,889,421
Ensembl chr15:24,398,419...24,398,922 		JBrowse link
G Cav3 caveolin 3 acts_upstream_of ISO
IEA		 MGI:2180558 (PMID:18552160)
GO_REF:0000107		 RGD
Ensembl		 PMID:18552160 GO_REF:0000107 NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 involved_in ISO
IEA		 (PMID:12507422)
GO_REF:0000107		 RGD
Ensembl		 PMID:12507422 GO_REF:0000107 NCBI chr 1:107,664,338...107,682,916
Ensembl chr 1:98,528,068...98,546,653 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A IEP RGD PMID:19906449 RGD:401959215 NCBI chr11:47,360,824...47,479,033
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Hdac2 histone deacetylase 2 IEP RGD PMID:19713680 RGD:9590231 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO
IEA		 MGI:2447620 (PMID:20382855)
GO_REF:0000107		 RGD
Ensembl		 PMID:20382855 GO_REF:0000107 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:19023134)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:19023134 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:25715999 RGD:401794570 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Lep leptin IDA RGD PMID:20738325 RGD:8693628 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Npm1 nucleophosmin 1 IEP RGD PMID:21444791 RGD:11535018 NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645
Ensembl chr  X:17,739,941...17,751,645 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 IEP RGD PMID:22564263 RGD:9835036 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:68,707,969...68,768,816 		JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within ISO
IEA		 MGI:3613572 (PMID:26975711)
GO_REF:0000107		 RGD
Ensembl		 PMID:26975711 GO_REF:0000107 NCBI chr 2:230,173,713...230,318,555
Ensembl chr 2:227,500,367...227,645,169 		JBrowse link
G Ryr2 ryanodine receptor 2 acts_upstream_of_or_within ISO MGI:3713774 (PMID:17431507) RGD PMID:17431507 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Tcap titin-cap involved_in ISO (PMID:15582318) RGD PMID:15582318 NCBI chr10:83,878,006...83,879,174
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 IMP RGD PMID:22564263 RGD:9835036 NCBI chr11:42,517,527...42,866,280
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
G Ttn titin involved_in ISO (PMID:11846417) RGD PMID:11846417 NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741 		JBrowse link
G Zfp418 zinc finger protein 418 acts_upstream_of_or_within ISO MGI:3050453|MGI:6369036|MGI:6369039 (PMID:29065170) RGD PMID:29065170 NCBI chr 1:75,614,531...75,627,367
Ensembl chr 1:66,581,287...66,594,242 		JBrowse link
cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bmp2 bone morphogenetic protein 2 IMP RGD PMID:26873969 RGD:11526363 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Camta2 calmodulin binding transcription activator 2 acts_upstream_of_or_within ISO
IEA		 (PMID:16678093)
GO_REF:0000107		 RGD
Ensembl		 PMID:16678093 GO_REF:0000107 NCBI chr10:55,882,071...55,900,575
Ensembl chr10:55,383,450...55,401,558 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO MGI:3054171|MGI:3778685 (PMID:20705924) RGD PMID:20705924 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 acts_upstream_of_or_within ISO MGI:3054171|MGI:3654150 (PMID:20705924) RGD PMID:20705924 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO
IEA		 (PMID:16603706)
GO_REF:0000107		 RGD
Ensembl		 PMID:16603706 GO_REF:0000107 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F acts_upstream_of_or_within ISO
IEA		 MGI:4128518 (PMID:19875726)
GO_REF:0000107		 RGD
Ensembl		 PMID:19875726 GO_REF:0000107 NCBI chr 1:192,620,891...192,700,681
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Kdm4a lysine demethylase 4A acts_upstream_of_or_within ISO (PMID:21555854) RGD PMID:21555854 NCBI chr 5:136,958,178...137,004,942
Ensembl chr 5:131,672,754...131,719,501 		JBrowse link
G Klf15 KLF transcription factor 15 involved_in ISO
IEA		 (PMID:17438289)
GO_REF:0000107		 RGD
Ensembl		 PMID:17438289 GO_REF:0000107 NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:122,965,807...122,978,374 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_or_within ISO (PMID:10531040) RGD PMID:10531040 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mir208b microRNA 208b acts_upstream_of_or_within ISO (PMID:24137001) RGD PMID:24137001 NCBI chr15:32,421,615...32,421,726
Ensembl chr15:28,451,638...28,451,749 		JBrowse link
G Myh6 myosin heavy chain 6 acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:107164 (PMID:12370307) RGD PMID:12370307 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nppa natriuretic peptide A acts_upstream_of
acts_upstream_of_or_within		 ISO
IEA		 MGI:1857231 (PMID:26536903)
GO_REF:0000107
MGI:1857231 (PMID:14985074), (PMID:15452027), (PMID:24137001)		 RGD
Ensembl		 PMID:14985074 PMID:15452027 PMID:24137001 PMID:26536903 GO_REF:0000107 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B acts_upstream_of_or_within ISO (PMID:24137001) RGD PMID:24137001 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha acts_upstream_of_or_within ISO MGI:103296 (PMID:12370307) RGD PMID:12370307 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Smad1 SMAD family member 1 IMP RGD PMID:26873969 RGD:11526363 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad4 SMAD family member 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Tcap titin-cap involved_in ISO (PMID:12507422) RGD PMID:12507422 NCBI chr10:83,878,006...83,879,174
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A acts_upstream_of_or_within ISO MGI:104774 (PMID:12782680) RGD PMID:12782680 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:104773 (PMID:12782680) RGD PMID:12782680 NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Agt angiotensinogen IDA RGD PMID:21376054 RGD:5129173 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:21173078 RGD:6903878 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akap13 A-kinase anchoring protein 13 IMP RGD PMID:18951085 RGD:2312638 NCBI chr 1:138,722,445...139,029,401
Ensembl chr 1:129,314,402...129,619,646 		JBrowse link
G Ang2 angiogenin, ribonuclease A family, member 2 acts_upstream_of_or_within ISO (PMID:29065170) RGD PMID:29065170 NCBI chr15:26,871,842...26,889,421
Ensembl chr15:24,398,419...24,398,922 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta IMP RGD PMID:21554860 RGD:6907064 NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Gata4 GATA binding protein 4 IDA RGD PMID:20971938 RGD:5131529 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IDA RGD PMID:27854077 RGD:13792737 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IMP RGD PMID:9769323 RGD:7495831 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Meis1 Meis homeobox 1 IMP RGD PMID:26597775 RGD:11554891 NCBI chr14:97,356,949...97,499,646
Ensembl chr14:93,155,419...93,294,265 		JBrowse link
G Myl2 myosin light chain 2 IEP RGD PMID:7657802 RGD:1580138 NCBI chr12:40,114,964...40,126,236
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Myocd myocardin IMP RGD PMID:18772130 RGD:5132877 NCBI chr10:50,332,356...50,426,819
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Nppa natriuretic peptide A IEP RGD PMID:7657802 RGD:1580138 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B IEP RGD PMID:7657802 RGD:1580138 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pdlim5 PDZ and LIM domain 5 involved_in IGI PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:230,952,248...231,120,275 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IMP RGD PMID:19542178 RGD:7775063 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Sorbs2 sorbin and SH3 domain containing 2 involved_in IGI PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr16:53,167,795...53,481,300
Ensembl chr16:46,435,237...46,626,514 		JBrowse link
negative regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16798733)		 Ensembl
RGD		 PMID:16798733 GO_REF:0000107 NCBI chr 4:121,423,936...121,439,094
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
G Cav3 caveolin 3 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:12847114)
GO_REF:0000107
MGI:2180558 (PMID:18552160)		 RGD
Ensembl		 PMID:12847114 PMID:18552160 GO_REF:0000107 NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Fbxo32 F-box protein 32 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Gata5 GATA binding protein 5 involved_in ISO
IEA		 (PMID:21633169)
GO_REF:0000107		 RGD
Ensembl		 PMID:21633169 GO_REF:0000107 NCBI chr 3:187,796,140...187,804,327
Ensembl chr 3:167,418,565...167,426,751 		JBrowse link
G Gdf1 growth differentiation factor 1 IMP RGD PMID:24275554 RGD:11252017 NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,097,314...19,112,519 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO (PMID:18258855) RGD PMID:18258855 NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within ISO (PMID:11782539) RGD PMID:11782539 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in IGI
IMP		 PMID:24657879 BHF-UCL PMID:24657879 PMID:24657879 RGD:11344938, RGD:11344938 NCBI chr17:19,983,217...20,163,598
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:28679649 RGD:329955564 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Mir1 microRNA 1 involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr18:2,160,327...2,160,413 JBrowse link
G Mir1a-1 microRNA 1a-1 involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22343712)		 UniProt
Ensembl
RGD		 PMID:22343712 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:86,815,491...87,085,117
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO
IEA		 (PMID:26491108)
GO_REF:0000107		 RGD
Ensembl		 PMID:26491108 GO_REF:0000107 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in ISO (PMID:15130891) RGD PMID:15130891 NCBI chr12:39,505,438...39,523,349
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO
IEA		 (PMID:19127022)
GO_REF:0000107		 RGD
Ensembl		 PMID:19127022 GO_REF:0000107 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16151019)		 Ensembl
RGD		 PMID:16151019 GO_REF:0000107 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:30980393 UniProt PMID:30980393 RGD:401901224 NCBI chr10:15,355,278...15,357,559
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO UniProtKB:P25119 (PMID:26491108) RGD PMID:26491108 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO UniProtKB:P25118 (PMID:26491108) RGD PMID:26491108 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Trim63 tripartite motif containing 63 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO
IEA		 (PMID:19287093)
GO_REF:0000107		 RGD
Ensembl		 PMID:19287093 GO_REF:0000107 NCBI chr13:47,708,157...47,807,389
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Foxo1 forkhead box O1 involved_in IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Lmna lamin A/C involved_in ISS
ISO		 GO_REF:0000024
(PMID:26436652)		 UniProt
RGD		 PMID:26436652 GO_REF:0000024 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in ISO
IEA		 (PMID:26359501), (PMID:26436652)
GO_REF:0000107		 RGD
Ensembl		 PMID:26359501 PMID:26436652 GO_REF:0000107 NCBI chr 8:86,815,491...87,085,117
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Smad3 SMAD family member 3 involved_in IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
negative regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 IMP RGD PMID:19358331 RGD:2312604 NCBI chr10:74,118,232...74,151,366
Ensembl chr10:73,621,883...73,653,896 		JBrowse link
G Cav3 caveolin 3 IMP RGD PMID:21170593 RGD:6784534 NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Ctdp1 CTD phosphatase subunit 1 IMP RGD PMID:22569295 RGD:9686371 NCBI chr18:76,129,243...76,193,404
Ensembl chr18:73,854,282...73,916,457 		JBrowse link
G Foxp1 forkhead box P1 IMP RGD PMID:26333362 RGD:11561912 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IMP RGD PMID:24190878 RGD:10449133 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (PMID:20516643) RGD PMID:20516643 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Mir451a microRNA 451a IMP RGD PMID:25209900 RGD:11558015 NCBI chr10:63,459,569...63,459,640
Ensembl chr10:62,961,520...62,961,591 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:22082674 RGD:11533929 NCBI chr 1:161,522,399...161,637,623
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pi16 peptidase inhibitor 16 acts_upstream_of_or_within ISO (PMID:17909105) RGD PMID:17909105 NCBI chr20:7,377,739...7,387,003
Ensembl chr20:7,376,126...7,385,383 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:22198280 RGD:5687133 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rbm10 RNA binding motif protein 10 IMP RGD PMID:30257214 RGD:151667449 NCBI chr  X:4,093,914...4,126,060
Ensembl chr  X:1,540,398...1,572,575 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 IMP RGD PMID:16380388 RGD:13524577 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IDA RGD PMID:9918533 RGD:7207376 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 IMP RGD PMID:25022898 RGD:13464131 NCBI chr11:56,847,837...56,886,302
Ensembl chr11:43,377,216...43,417,202 		JBrowse link
G Yy1 YY1 transcription factor IMP RGD PMID:18632988 RGD:9588273 NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
G Zfp418 zinc finger protein 418 acts_upstream_of_or_within ISO (PMID:29065170) RGD PMID:29065170 NCBI chr 1:75,614,531...75,627,367
Ensembl chr 1:66,581,287...66,594,242 		JBrowse link
negative regulation of muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mstn myostatin IMP RGD PMID:16810717 RGD:2303557 NCBI chr 9:55,944,513...55,950,913
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
negative regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igfbp5 insulin-like growth factor binding protein 5 involved_in ISO
IEA		 (PMID:15010534)
GO_REF:0000107		 RGD
Ensembl		 PMID:15010534 GO_REF:0000107 NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
physiological cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir223 microRNA 223 IMP RGD PMID:27226563 RGD:329322878 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
positive regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 IMP RGD PMID:29466442 RGD:329337358 NCBI chr13:80,280,595...80,366,939
Ensembl chr13:77,768,468...77,833,951 		JBrowse link
G Adk adenosine kinase IMP RGD PMID:21335462 RGD:6482642 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Adra1a adrenoceptor alpha 1A acts_upstream_of_or_within ISO (PMID:27994061) RGD PMID:27994061 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Agt angiotensinogen involved_in IDA PMID:8348686 BHF-UCL PMID:8348686 RGD:8553767 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Becn1 beclin 1 acts_upstream_of_or_within ISO
IEA		 MGI:2683833 (PMID:27994061)
GO_REF:0000107		 RGD
Ensembl		 PMID:27994061 GO_REF:0000107 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA
IMP		 (PMID:17921333)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921333 PMID:17921333 GO_REF:0000107, RGD:2302083 NCBI chr 4:121,423,936...121,439,094
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in ISO
ISS		 (PMID:17179159)
GO_REF:0000024		 RGD
UniProt		 PMID:17179159 GO_REF:0000024 NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 IMP RGD PMID:20081228 RGD:9698419 NCBI chr 3:36,394,168...36,399,016
Ensembl chr 3:15,996,468...16,002,410 		JBrowse link
G Ece1 endothelin converting enzyme 1 IMP RGD PMID:20099522 RGD:7243873 NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 involved_in ISO
IEA		 (PMID:12847114)
GO_REF:0000107		 RGD
Ensembl		 PMID:12847114 GO_REF:0000107 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Gsn gelsolin IMP RGD PMID:24505034 RGD:329333013 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in ISO
IEA		 UniProtKB:P63328|UniProtKB:Q02078 (PMID:24161931)
GO_REF:0000107		 RGD
Ensembl		 PMID:24161931 GO_REF:0000107 NCBI chr16:37,928,145...37,931,488
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 (PMID:19654000), (PMID:19933931)
GO_REF:0000107		 RGD
Ensembl		 PMID:19654000 PMID:19933931 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mef2a myocyte enhancer factor 2a involved_in ISO
IEA		 UniProtKB:P61296 (PMID:24161931)
GO_REF:0000107		 RGD
Ensembl		 PMID:24161931 GO_REF:0000107 NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in IMP PMID:19654000 UniProt PMID:19654000 RGD:5131609 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mrtfa myocardin related transcription factor A IMP RGD PMID:21280178 RGD:529389387 NCBI chr 7:114,424,481...114,594,594
Ensembl chr 7:112,544,312...112,714,418 		JBrowse link
G Mtpn myotrophin involved_in ISO
IMP		 (PMID:10329199)
PMID:18693253		 RGD PMID:10329199 PMID:18693253 RGD:8553542 NCBI chr 4:65,126,390...65,153,803
Ensembl chr 4:64,157,641...64,186,724 		JBrowse link
G Myocd myocardin IMP RGD PMID:21280178 RGD:529389387 NCBI chr10:50,332,356...50,426,819
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 involved_in IMP PMID:30980393 UniProt PMID:30980393 RGD:401901224 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pde5a phosphodiesterase 5A involved_in ISO (PMID:19127022) RGD PMID:19127022 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:25799991)		 UniProt
Ensembl
RGD		 PMID:25799991 GO_REF:0000024 GO_REF:0000107 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO RNAcentral:URS0000021B51_10090|UniProtKB:P61296 (PMID:24161931), (PMID:24657879) RGD PMID:24161931 PMID:24657879 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prkca protein kinase C, alpha involved_in IDA PMID:11864993 UniProt PMID:11864993 RGD:8554603 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ptk2 protein tyrosine kinase 2 acts_upstream_of_or_within ISO (PMID:27994061) RGD PMID:27994061 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:28679962)		 Ensembl
RGD		 PMID:28679962 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IMP
ISO		 PMID:28679962
(PMID:28679962)		 RGD PMID:28679962 PMID:28679962 RGD:13601991 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO
IEA		 (PMID:21359875)
GO_REF:0000107		 RGD
Ensembl		 PMID:21359875 GO_REF:0000107 NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Twf1 twinfilin actin-binding protein 1 involved_in ISO (PMID:20571053) RGD PMID:20571053 NCBI chr 7:127,595,210...127,607,821
Ensembl chr 7:125,716,015...125,727,894 		JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 involved_in ISO
IEA		 (PMID:19287093)
GO_REF:0000107		 RGD
Ensembl		 PMID:19287093 GO_REF:0000107 NCBI chr 2:121,409,436...121,487,095
Ensembl chr 2:119,481,400...119,558,855 		JBrowse link
positive regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18194989 RGD:5129139 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Akap6 A-kinase anchoring protein 6 IMP
IDA		 RGD PMID:21550986 PMID:16306226 RGD:6902940, RGD:2312613 NCBI chr 6:75,919,350...76,359,667
Ensembl chr 6:70,184,175...70,619,738 		JBrowse link
G Ccn4 cellular communication network factor 4 IMP RGD PMID:21376054 RGD:5129173 NCBI chr 7:100,534,578...100,566,287
Ensembl chr 7:98,645,182...98,677,248 		JBrowse link
G Ddx39b DExD-box helicase 39B IMP RGD PMID:20116367 RGD:10401141 NCBI chr20:3,577,200...3,589,651
Ensembl chr20:3,572,056...3,584,996 		JBrowse link
G Edn1 endothelin 1 involved_in ISO
IEA		 RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217)
GO_REF:0000107		 RGD
Ensembl		 PMID:24117217 GO_REF:0000107 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:12724418 RGD:2312280 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fdps farnesyl diphosphate synthase IMP RGD PMID:19716825 RGD:2316294 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Hamp hepcidin antimicrobial peptide IMP RGD PMID:24424338 RGD:11041632 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217)
GO_REF:0000107		 RGD
Ensembl		 PMID:24117217 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mir19a microRNA 19a acts_upstream_of ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr15:98,588,131...98,588,212
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 acts_upstream_of ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr15:98,588,433...98,588,519
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir19b2 microRNA 19b-2 acts_upstream_of ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr  X:137,343,058...137,343,153
Ensembl chr  X:132,422,072...132,422,167 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:21318349 PMID:21933187 RGD:10040977, RGD:10040978 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:22989630 RGD:7174736 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 IMP RGD PMID:23261455 RGD:13514044 NCBI chr15:26,494,722...26,517,893
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 IMP RGD PMID:23487407 RGD:8693424 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:25281201 RGD:13514043 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 IDA RGD PMID:21325829 RGD:9681466 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Trip10 thyroid hormone receptor interactor 10 IMP RGD PMID:23915320 RGD:11535145 NCBI chr 9:2,219,695...2,234,771
Ensembl chr 9:2,133,671...2,147,799 		JBrowse link
positive regulation of skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:23470307 RGD:10041029 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mymk myomaker, myoblast fusion factor involved_in ISO
IEA		 (PMID:28186492)
GO_REF:0000107		 RGD
Ensembl		 PMID:28186492 GO_REF:0000107 NCBI chr 3:30,786,443...30,795,374
Ensembl chr 3:10,388,361...10,397,343 		JBrowse link
regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmcd1 LIM and cysteine-rich domains 1 involved_in ISO
IEA		 (PMID:20026769)
GO_REF:0000107		 RGD
Ensembl		 PMID:20026769 GO_REF:0000107 NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta IMP RGD PMID:31709908 RGD:329901803 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA		 (PMID:17921333)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921333 GO_REF:0000107 NCBI chr 4:121,423,936...121,439,094
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col14a1 collagen type XIV alpha 1 chain acts_upstream_of_or_within ISO
IEA		 MGI:3846440 (PMID:22906538)
GO_REF:0000107		 RGD
Ensembl		 PMID:22906538 GO_REF:0000107 NCBI chr 7:88,611,827...88,826,939
Ensembl chr 7:86,722,094...86,937,214 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A IMP RGD PMID:21273244 RGD:401940178 NCBI chr11:47,360,824...47,479,033
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
skeletal muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor IMP RGD PMID:7957162 RGD:10043318 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Myoc myocilin involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22371502)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22371502 GO_REF:0000024 GO_REF:0000107 NCBI chr13:77,509,963...77,520,361
Ensembl chr13:74,976,730...74,987,127 		JBrowse link
smooth muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain involved_in IMP PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    multicellular organismal process 9031
      system process 3586
        muscle system process 496
          muscle hypertrophy 136
            muscle hypertrophy in response to stress + 32
            negative regulation of muscle hypertrophy + 42
            physiological muscle hypertrophy + 56
            positive regulation of muscle hypertrophy + 49
            regulation of muscle hypertrophy + 92
            smooth muscle hypertrophy + 1
            striated muscle hypertrophy + 134
paths to the root